The scientist’s investigation covers issues in DNA replication, Origin recognition complex, Cell biology, Molecular biology and Cell cycle. His work in DNA replication addresses issues such as Saccharomyces cerevisiae, which are connected to fields such as Complementary DNA and Mitotic cell cycle. His Origin recognition complex study combines topics from a wide range of disciplines, such as S phase and Control of chromosome duplication.
Hisao Masai works mostly in the field of Cell biology, limiting it down to topics relating to Cell culture and, in certain cases, Embryonic stem cell, Cell cycle progression and Multicellular organism, as a part of the same area of interest. His work deals with themes such as Cell cycle checkpoint, pSC101 and Replication protein A, which intersect with Molecular biology. His studies in Cell cycle integrate themes in fields like Cell nucleus, Genetically modified mouse and Kinase.
His main research concerns Cell biology, DNA replication, Origin recognition complex, Control of chromosome duplication and Genetics. His study in Cell biology is interdisciplinary in nature, drawing from both Chromatin, Cell cycle and DNA repair. His DNA replication research includes elements of Molecular biology, Saccharomyces cerevisiae and Helicase.
His study looks at the relationship between Molecular biology and topics such as Cell cycle checkpoint, which overlap with DNA synthesis. His Origin recognition complex study incorporates themes from Pre-replication complex, DNA replication factor CDT1, S phase and Minichromosome maintenance. His Control of chromosome duplication research is multidisciplinary, incorporating perspectives in HMG-box, Replication protein A and Origin of replication.
Cell biology, DNA replication, Chromatin, G-quadruplex and Replication timing are his primary areas of study. Hisao Masai has included themes like Histone H3 and Origin recognition complex in his Cell biology study. His research on Origin recognition complex concerns the broader Genetics.
DNA Replication Timing and Control of chromosome duplication are among the areas of DNA replication where he concentrates his study. His Chromatin research includes themes of Molecular biology and Protein–DNA interaction. His Replication timing research incorporates themes from Replication Initiation and Transcription.
His scientific interests lie mostly in Cell biology, DNA replication, Kinase, Chromatin and G-quadruplex. His Cell biology study combines topics in areas such as Genetics, Demethylase, Tetratricopeptide, Mutant and Replication timing. His DNA replication research entails a greater understanding of DNA.
Hisao Masai interconnects Cancer cell, Mediator, Phosphorylation and Effector in the investigation of issues within Kinase. In his study, Point mutation, C-terminus, Phosphatase and Amino acid is strongly linked to Yeast, which falls under the umbrella field of Chromatin. His Origin of replication study combines topics in areas such as Shelterin, Origin recognition complex, Control of chromosome duplication and Helicase.
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Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Asako Sakaue-Sawano;Hiroshi Kurokawa;Toshifumi Morimura;Aki Hanyu.
Eukaryotic chromosome DNA replication: where, when, and how?
Hisao Masai;Seiji Matsumoto;Zhiying You;Naoko Yoshizawa-Sugata.
Annual Review of Biochemistry (2010)
Rif1 is a global regulator of timing of replication origin firing in fission yeast
Motoshi Hayano;Yutaka Kanoh;Seiji Matsumoto;Claire Renard-Guillet.
Genes & Development (2012)
Rif1 regulates the replication timing domains on the human genome
Satoshi Yamazaki;Aii Ishii;Yutaka Kanoh;Masako Oda.
The EMBO Journal (2012)
Cdc7 kinase complex: a key regulator in the initiation of DNA replication.
Hisao Masai;Hisao Masai;Ken-Ichi Arai.
Journal of Cellular Physiology (2002)
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.
H. Masai;T. Miyake;K.-I. Arai.
The EMBO Journal (1995)
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7.
Noriko Sato;Ken‐ichi Arai;Hisao Masai.
The EMBO Journal (1997)
Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin
Hisao Masai;Chika Taniyama;Keiko Ogino;Etsuko Matsui.
Journal of Biological Chemistry (2006)
Human Cdc7-related Kinase Complex: IN VITRO PHOSPHORYLATION OF MCM BY CONCERTED ACTIONS OF Cdks AND Cdc7 AND THAT OF A CRITICAL THREONINE RESIDUE OF Cdc7 BY Cdks *
Hisao Masai;Etsuko Matsui;Zhiying You;Yukio Ishimi.
Journal of Biological Chemistry (2000)
A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells.
Hiroyuki Kumagai;Noriko Sato;Masayuki Yamada;Daniel Mahony.
Molecular and Cellular Biology (1999)
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