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Ken-ichi Arai

Ken-ichi Arai

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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
95
Citations
33954
World Ranking
633
National Ranking
46

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Ken-ichi Arai is a researcher affiliated with the University of Tokyo in Japan. Their work primarily focuses on medicine, with specific attention to surgery and biomedical engineering. The research also intersects with molecular biology, cellular and molecular neuroscience, and biomaterials, illustrating a broad engagement with both clinical and experimental biomedical sciences.

The scientist's research interests concentrate on several main topics including tissue engineering and regenerative medicine, 3D printing in biomedical research, electrospun nanofibers in biomedical applications, pluripotent stem cells research, neuropeptides and animal physiology, additive manufacturing and 3D printing technologies, and pharmacological receptor mechanisms and effects.

Ken-ichi Arai has published extensively in several venues. Frequent publication outlets include PLoS ONE, Graefe's Archive for Clinical and Experimental Ophthalmology, Clinical Nutrition ESPEN, Advanced Healthcare Materials, and Scientific Reports. The diversity of journals reflects an interdisciplinary approach bridging clinical applications and advanced biomedical materials research.

Recent selected publications highlight the application of bio-3D printing and scaffold-free tissue construction technologies:

  • Scaffold-Free Bio-3D Printing Using Spheroids as "Bio-Inks" for Tissue (Re-)Construction and Drug Response Tests (2020, Advanced Healthcare Materials)
  • Drug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer (2020, Scientific Reports)
  • Cryopreservation method for spheroids and fabrication of scaffold-free tubular constructs (2020, PLoS ONE)
  • Scaffold-Free Tubular Engineered Heart Tissue From Human Induced Pluripotent Stem Cells Using Bio-3D Printing Technology in vivo (2022, Frontiers in Cardiovascular Medicine)
  • Distribution of amniotic stem cells in human term amnion membrane (2021, Microscopy)

Ken-ichi Arai has collaborated frequently with several researchers, including Koichi Nakayama, Daiki Murata, Shoko Takao, Toshiko Yoshida, and Soichiro Ide. These collaborations have contributed to developing advances in biofabrication and regenerative medicine.

Best Publications

  • SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

    Y. Takebe;M. Seiki;J.-I. Fujisawa;P. Hoy

  • Cytokines: Coordinators of Immune and Inflammatory Responses

    Ken-ichi Arai;Frank Lee;Atsushi Miyajima;Shoichiro Miyatake

  • IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2

    J Pène;F Rousset;F Brière;I Chrétien

  • Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.

    Motonari Kondo;Toshikazu Takeshita;Naoto Ishii;Masataka Nakamura

  • Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

    Kazuhiro Hayashida;Toshio Kitamura;Daniel M. Gorman;Ken-Ichi Arai

  • Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

    Toshio Kitamura;Noriko Sato;Ken-ichi Arai;Atsushi Miyajima

  • Cytokine receptors and signal transduction

    Atsushi Miyajima;I Toshio Kitamura;I Nobuyuki Harada;Takashi Yokota

  • Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities.

    T Yokota;T Otsuka;T Mosmann;J Banchereau

  • Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

    T Defrance;J P Aubry;F Rousset;B Vanbervliet

  • Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells

    Takashi Yokota;Frank Lee;Donna Rennick;Carol Hall

  • Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.

    Naoto Itoh;Shin Yonehara;Jolanda Schreurs;Daniel M Gorman

  • Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling.

    N. Sato;K. Sakamaki;N. Terada;K.-I. Arai

  • Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

    T. Kinoshita;T. Yokota;K.-I. Arai;A. Miyajima

  • Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae

    N. Nakayama;A. Miyajima;K. Arai

  • Cytokine Receptors and Signal Transduction

    Atsushi Miyajima

  • GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction

    Ikuko Miyajima;Masato Nakafuku;Naoki Nakayama;Charles Brenner

  • Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

    Frank Lee;Takashi Yokota;Takeshi Otsuka;Lorraine Gemmell

  • Studies on Polypeptide Elongation Factors from Escherichia coli II. PURIFICATION OF FACTORS Tu-GUANOSINE DIPHOSPHATE, Ts, AND Tu-Ts, AND CRYSTALLIZATION OF Tu-GUANOSINE DIPHOSPHATE AND Tu-Ts

    Ken-Ichi Arai;Masao Kawakita;Yoshito Kaziro

  • Recombinant interleukin 4 promotes the growth of human T cells.

    H. Spits;H. Yssel;Y. Takebe;N. Arai

  • Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

    S Miyatake;T Otsuka;T Yokota;F Lee

Frequent Co-Authors

Naoko Arai
Naoko Arai University of Tokyo
Takashi Yokota
Takashi Yokota Kanazawa University
Atsushi Miyajima
Atsushi Miyajima University of Tokyo
Hisao Masai
Hisao Masai Tokyo Metropolitan Institute of Medical Science
Yoshito Kaziro
Yoshito Kaziro Kyoto University
Noriko Sato
Noriko Sato Tokyo Medical and Dental University
Masaaki Muramatsu
Masaaki Muramatsu Tokyo Medical and Dental University
Hiroshi Tokumitsu
Hiroshi Tokumitsu Okayama University
Frank S. Lee
Frank S. Lee University of Pennsylvania

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