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Kazuo Sugamura

Kazuo Sugamura

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Biology and Biochemistry
Japan
2025

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
32843
World Ranking
2008
National Ranking
116

Research.com Recognitions

  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Kazuo Sugamura is affiliated with Tohoku University in Japan and specializes in research spanning biochemistry, genetics, molecular biology, and medicine. Their work focuses on cancer research, particularly in molecular mechanisms underlying cancer stem cell maintenance, tumorigenesis, and metastasis.

The scientist's research covers key topics including:

  • Cholangiocarcinoma and gallbladder cancer studies
  • Epigenetics and DNA methylation
  • Cancer-related gene regulation
  • Cancer cells and metastasis
  • NF-κB signaling pathways
  • Immune cell function and interaction
  • MicroRNA in disease regulation

Their recent publications reflect a focus on molecular pathways involved in cancer stem cell dormancy and aggressiveness across various cancer types. Notable papers include:

  • "BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma," 2020, Scientific Reports
  • "BEX2 is required for maintaining dormant cancer stem cell in hepatocellular carcinoma," 2021, Cancer Science
  • "CD109 promotes the tumorigenic ability and metastatic motility of pancreatic ductal adenocarcinoma cells," 2020, Pancreatology
  • "Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein," 2021, Biochemical and Biophysical Research Communications
  • "RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer," 2022, Scientific Reports

Their frequent coauthors include Keiichi Tamai, Jun Yasuda, Kazunori Yamaguchi, Rie Shibuya-Takahashi, and Mai Mochizuki, indicating collaborative research efforts primarily within molecular oncology and cancer biology fields.

Kazuo Sugamura often publishes in journals such as Cancer Science, Scientific Reports, Pancreatology, Biochemical and Biophysical Research Communications, and Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. Their publication record is concentrated on molecular biology and cancer research topics.

Main fields of investigation for Sugamura center on biochemistry, genetics and molecular biology with a strong clinical emphasis on oncology and cancer stem cells. Subfields contributing to their work include molecular biology, oncology, immunology, surgery, and cancer research.

Best Publications

  • NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

    Mamoru Ito;Hidefumi Hiramatsu;Kimio Kobayashi;Kazutomo Suzue

  • Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

    Hiroyuki Hirai;Kazuya Tanaka;Osamu Yoshie;Kazuyuki Ogawa

  • Cloning of the gamma chain of the human IL-2 receptor

    Toshikazu Takeshita;Hironobu Asao;Kiyoshi Ohtani;Naoto Ishii

  • Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4.

    Motonari Kondo;Toshikazu Takeshita;Naoto Ishii;Masataka Nakamura

  • Cutting Edge: The Common γ-Chain Is an Indispensable Subunit of the IL-21 Receptor Complex

    Hironobu Asao;Chikara Okuyama;Satoru Kumaki;Naoto Ishii

  • The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.

    Kazuo Sugamura;Hironobu Asao;Motonari Kondo;Nobuyuki Tanaka

  • Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

    Motonari Kondo;David C. Scherer;Toshihiro Miyamoto;Angela G. King

  • Selective expression of a novel surface molecule by human Th2 cells in vivo.

    Kinya Nagata;Kazuya Tanaka;Kazuyuki Ogawa;Kazumi Kemmotsu

  • Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes

    Motonari Kondo;Toshikazu Takeshita;Masaya Higuchi;Masataka Nakamura

  • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40

    Kazuo Sugamura;Naoto Ishii;Andrew D. Weinberg

  • CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s)

    Kinya Nagata;Hiroyuki Hirai;Kazuya Tanaka;Kazuyuki Ogawa

  • Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted

    Yuuki Inoue;Nobuyuki Tanaka;Yoshinori Tanaka;Shingo Inoue

  • Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells

    Ikuo Takeda;Shoji Ine;Nigel Killeen;Lishomwa C. Ndhlovu

  • Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

    Tomoko Shima;Yasushi Sasaki;Mika Itoh;Akitoshi Nakashima

  • Impairment of Antigen-Presenting Cell Function in Mice Lacking Expression of Ox40 Ligand

    Kazuko Murata;Naoto Ishii;Hiroshi Takano;Shigeto Miura

  • Positional identification of TNFSF4 , encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility

    Xiaosong Wang;Massimiliano Ria;Peter M Kelmenson;Per Eriksson

  • Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain

    Kazuyuki Ohbo;Toshio Suda;Motohiro Hashiyama;Akio Mantani

  • Human parvovirus B19 as a causative agent for rheumatoid arthritis

    Yuichi Takahashi;Chihiro Murai;Shinobu Shibata;Yasuhiko Munakata

  • c-myc Is a Downstream Target of the Smad Pathway

    Ken Yagi;Masao Furuhashi;Hiromasa Aoki;Daisuke Goto

  • Human Parvovirus B19 Nonstructural (NS1) Protein Induces Apoptosis in Erythroid Lineage Cells

    Stanley Moffatt;Nobuo Yaegashi;Kohtaro Tada;Nobuyuki Tanaka

Frequent Co-Authors

Naoto Ishii
Naoto Ishii Tohoku University
Nobuo Yaegashi
Nobuo Yaegashi Tohoku University
Yorio Hinuma
Yorio Hinuma Kyoto University
Lishomwa C. Ndhlovu
Lishomwa C. Ndhlovu Cornell University
Hiroaki Shimokawa
Hiroaki Shimokawa Tohoku University
Yoshio Koyanagi
Yoshio Koyanagi Kyoto University
Fabio Candotti
Fabio Candotti National Institutes of Health
Tatsutoshi Nakahata
Tatsutoshi Nakahata Kyoto University
Yuichi Endo
Yuichi Endo Fukushima Medical University
Teizo Fujita
Teizo Fujita Fukushima Prefectural General Hygiene Institute

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