World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
66
Citations
14543
World Ranking
2771
National Ranking
1317

Overview

Xian Chang Li is affiliated with Cornell University in the United States and has contributed extensively to the fields of medicine, immunology, and microbiology. Their research primarily focuses on immune cell function, molecular biology, oncology, and transplantation sciences. Li has a strong publication record centered on the mechanisms of immune regulation, cancer immunotherapy, and organ transplantation outcomes.

Li's work spans several subfields of study, including:

  • Immunology
  • Molecular Biology
  • Oncology
  • Surgery
  • Transplantation

Main topics addressed in their research include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Renal Transplantation Outcomes and Treatments
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Organ Transplantation Techniques and Outcomes
  • IL-33, ST2, and ILC Pathways

Frequent co-authors in Li's collaborative research efforts include:

  • Wenhao Chen
  • Laurie J. Minze
  • Xiang Xiao
  • Dawei Zou
  • Guangchuan Wang

Li has published extensively in prominent journals such as:

  • American Journal of Transplantation
  • PubMed
  • Cellular and Molecular Immunology
  • Transplantation
  • SSRN Electronic Journal

Selected recent papers authored or co-authored by Xian Chang Li include:

  • Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate, 2020, Frontiers in Cell and Developmental Biology
  • PIRs mediate innate myeloid cell memory to nonself MHC molecules, 2020, Science
  • Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells, 2021, Nature Communications
  • Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway, 2020, Aging
  • TRIM18 is a critical regulator of viral myocarditis and organ inflammation, 2022, Journal of Biomedical Science

The scope of Li's research demonstrates a focus on immune response mechanisms, regulatory pathways in cancer and viral diseases, and therapeutic strategies related to transplantation and immunotherapy.

Best Publications

  • Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

    Yongsheng Li;Xian Chang Li;Xin Xiao Zheng;Andrew D. Wells

  • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

    Andrew D. Wells;Xian Chang Li;Yongsheng Li;Matthew C. Walsh

  • OX40 costimulation turns off Foxp3+ Tregs.

    Minh Diem Vu;Xiang Xiao;Wenda Gao;Nicolas Degauque

  • IL-15 and IL-2: a matter of life and death for T cells in vivo.

    Xian Chang Li;Gulcin Demirci;Sylvie Ferrari-Lacraz;Chris Groves

  • Natural Killer Cells Promote Immune Tolerance by Regulating Inflammatory TH17 Cells at the Human Maternal-Fetal Interface

    Binqing Fu;Xian Chang Li;Xian Chang Li;Rui Sun;Xianhong Tong

  • NK cells promote transplant tolerance by killing donor antigen-presenting cells.

    Guang Yu;Xuemin Xu;Minh Diem Vu;Elizabeth D. Kilpatrick

  • Leptin Receptor Expression and Signaling in Lymphocytes: Kinetics During Lymphocyte Activation, Role in Lymphocyte Survival, and Response to High Fat Diet in Mice

    Elizabeth Papathanassoglou;Karim El-Haschimi;Xian Chang Li;Giuseppe Matarese

  • Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate

    Preston R. Arnold;Andrew D. Wells;Xian C. Li

  • OX40 signaling favors the induction of TH9 cells and airway inflammation

    Xiang Xiao;Savithri Balasubramanian;Wentao Liu;Xiufeng Chu

  • Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series.

    Keri E Lunsford;Milind Javle;Kirk Heyne;Rachna T Shroff

  • TRIM29 promotes DNA virus infections by inhibiting innate immune response.

    Junji Xing;Ao Zhang;Hua Zhang;Jin Wang

  • T cell death and transplantation tolerance.

    Xian Chang Li;Terry B. Strom;Laurence A. Turka;Andrew D. Wells

  • Costimulatory pathways in transplantation: challenges and new developments.

    Xian Chang Li;David M. Rothstein;Mohamed H. Sayegh

  • CTLA4 Signals Are Required to Optimally Induce Allograft Tolerance with Combined Donor-Specific Transfusion and Anti-CD154 Monoclonal Antibody Treatment

    Xin Xiao Zheng;Thomas G. Markees;Wayne W. Hancock;Yongsheng Li

  • Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis.

    Sylvie Ferrari-Lacraz;Eric Zanelli;Manfred Neuberg;Elina Donskoy

  • Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival.

    Wenda Gao;Gülçin Demirci;Terry B Strom;Xian Chang Li

  • Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract

    Junji Xing;Leiyun Weng;Bin Yuan;Zhuo Wang

  • The first case of ischemia‐free organ transplantation in humans: A proof of concept

    Xiaoshun He;Zhiyong Guo;Qiang Zhao;Weiqiang Ju

  • Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment.

    Yongsheng Li;Xin Xiao Zheng;Xian Chang Li;Martin S. Zand

  • Targeting the IL-15 Receptor with an Antagonist IL-15 Mutant/Fcγ2a Protein Blocks Delayed-Type Hypersensitivity

    Yon Su Kim;Wlodzimierz Maslinski;Xin Xiao Zheng;A. Christopher Stevens

  • Critical, but Conditional, Role of OX40 in Memory T Cell-Mediated Rejection

    Minh Diem Vu;Michael R. Clarkson;Hideo Yagita;Laurence A. Turka

  • Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1.

    U Lorenz;A D Bergemann;H N Steinberg;J G Flanagan

Frequent Co-Authors

Xin Xiao Zheng
Xin Xiao Zheng University of Pittsburgh
Terry B. Strom
Terry B. Strom Beth Israel Deaconess Medical Center
Malgorzata Kloc
Malgorzata Kloc Houston Methodist
Laurence A. Turka
Laurence A. Turka Harvard University
Mohamed H. Sayegh
Mohamed H. Sayegh American University of Beirut
Andrew D. Wells
Andrew D. Wells Children's Hospital of Philadelphia
Robert Zhong
Robert Zhong University of Western Ontario
Wenda Gao
Wenda Gao Beth Israel Deaconess Medical Center
Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania
Stefan G. Tullius
Stefan G. Tullius Brigham and Women's Hospital

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