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D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8379
World Ranking
18048
National Ranking
7381

Overview

Nader Najafian is affiliated with Brigham and Women's Hospital in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a notable focus on Molecular Biology, Immunology, Surgery, Transplantation, and Physiology.

Their work covers several main topics, including the Complement system in diseases, Renal Transplantation Outcomes and Treatments, Adenosine and Purinergic Signaling, Renal Diseases and Glomerulopathies, Coagulation, Bradykinin, Polyphosphates, and Angioedema, as well as Porphyrin Metabolism and Disorders and Heme Oxygenase-1 and Carbon Monoxide.

Recent publications reflect the diversity of their research interests. These include:

  • Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria (2020, Clinical Pharmacokinetics)
  • Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies (2022, American Journal of Nephrology)
  • A Drug-Drug Interaction Study Evaluating the Effect of Givosiran, a Small Interfering Ribonucleic Acid, on Cytochrome P450 Activity in the Liver (2021, Clinical Pharmacology & Therapeutics)
  • Advancing mouse models for transplantation research (2024, American Journal of Transplantation)

The frequent venues for Najafian's publications include Clinical Pharmacokinetics, American Journal of Nephrology, Clinical Pharmacology & Therapeutics, and American Journal of Transplantation.

Frequent collaborators in their research are Valerie A. Clausen, Gabriel J. Robbie, Prajakta Badri, Xuemin Jiang, and Anna Borodovsky.

Best Publications

  • Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

    Qing Ding;Melissa Yeung;Geoffrey Camirand;Qiang Zeng

  • A Novel Mechanism of Action for Anti-Thymocyte Globulin: Induction of CD4+CD25+Foxp3+ Regulatory T Cells

    Marta Lopez;Michael R. Clarkson;Monica Albin;Mohamed H. Sayegh

  • Regulatory functions of CD8+CD28– T cells in an autoimmune disease model

    Nader Najafian;Tanuja Chitnis;Alan D. Salama;Bing Zhu

  • Regulatory CD25+ T Cells in Human Kidney Transplant Recipients

    Alan D. Salama;Nader Najafian;Michael R. Clarkson;William E. Harmon

  • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.

    Tanuja Chitnis;Nader Najafian;Christina Benou;Alan D. Salama

  • Role of the Programmed Death-1 Pathway in Regulation of Alloimmune Responses In Vivo

    Sigrid E. Sandner;Michael R. Clarkson;Alan D. Salama;Alberto Sanchez-Fueyo

  • Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients.

    C. Ebner;S. Schenk;Nader Najafian;U. Siemann

  • PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection

    Katsunori Tanaka;Monica J. Albin;Xueli Yuan;Kazuhiro Yamaura

  • Analysis of the Role of Negative T Cell Costimulatory Pathways in CD4 and CD8 T Cell-Mediated Alloimmune Responses In Vivo

    Toshiro Ito;Takuya Ueno;Michael R. Clarkson;Xueli Yuan

  • Enzyme-Linked Immunosorbent Spot Assay Analysis of Peripheral Blood Lymphocyte Reactivity to Donor HLA-DR Peptides: Potential Novel Assay for Prediction of Outcomes for Renal Transplant Recipients

    Nader Najafian;Alan D. Salama;Eugenia V. Fedoseyeva;Gilles Benichou

  • An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria

    Abigail Liebow;Xingsheng Li;Timothy Racie;Julia Hettinger

  • Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality.

    Asim Saha;Kazutoshi Aoyama;Patricia A. Taylor;Brent H. Koehn

  • Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study

    Philip J O'Connell;Weijia Zhang;Madhav C Menon;Zhengzi Yi

  • CTLA4-Ig: a novel immunosuppressive agent.

    Nader Najafian;Mohamed H Sayegh

  • Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

    Sheng Xiao;Nader Najafian;Jay Reddy;Monica Albin

  • T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner

    Yoichiro Uchida;Bibo Ke;Maria Cecilia S Freitas;Hideo Yagita

  • The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

    Takuya Ueno;Antje Habicht;Michael R. Clarkson;Monica J. Albin

  • In Vitro and In Vivo Studies of IgG-derived Treg Epitopes (Tregitopes): A Promising New Tool for Tolerance Induction and Treatment of Autoimmunity

    Leslie P. Cousens;Nader Najafian;Federico Mingozzi;Wassim Elyaman

  • New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.

    Masayuki Sho;Sigrid E. Sandner;Nader Najafian;Alan D. Salama

  • Alloreactivity in Renal Transplant Recipients with and without Chronic Allograft Nephropathy

    Emilio D. Poggio;Michael Clemente;Jocelyn Riley;Meagan Roddy

Frequent Co-Authors

Mohamed H. Sayegh
Mohamed H. Sayegh American University of Beirut
Hideo Yagita
Hideo Yagita Juntendo University
Alan D. Salama
Alan D. Salama University College London
Anil Chandraker
Anil Chandraker Brigham and Women's Hospital
Hisaya Akiba
Hisaya Akiba Juntendo University
Samia J. Khoury
Samia J. Khoury American University of Beirut
Hugh Auchincloss
Hugh Auchincloss National Institutes of Health
Miyuki Azuma
Miyuki Azuma Tokyo Medical and Dental University
Robert B. Colvin
Robert B. Colvin Harvard University
Arlene H. Sharpe
Arlene H. Sharpe Harvard University

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