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Immunology

D-Index
65
Citations
16385
World Ranking
2831
National Ranking
1340

Overview

Fabio Candotti is affiliated with the National Institutes of Health in the United States. Their research spans multiple disciplines, primarily focused on medicine, immunology, and microbiology, with additional work in biochemistry, genetics, and molecular biology.

Their recent publications demonstrate a strong focus on gene therapy and immunodeficiency disorders. Notable papers include:

  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency (2021, New England Journal of Medicine)
  • The role of B cells in COVID-19 infection and vaccination (2022, Frontiers in Immunology)
  • Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients (2021, Journal of Clinical Immunology)
  • Long-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency (2021, Blood)
  • Access to gene therapy for rare diseases when commercialization is not fit for purpose (2023, Nature Medicine)

Candotti frequently collaborates with other scientists, including Katerina Theodoropoulou, Isabelle Meyts, Michaël Hofer, Donald B. Kohn, and Elizabeth Garabedian.

The scientist's work has been published predominantly in venues like the Journal of Clinical Immunology, Frontiers in Immunology, Pediatric Allergy and Immunology, Revue Médicale Suisse, and Blood.

Their main fields of study cover:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Candotti's research areas also include several subfields of study such as:

  • Immunology
  • Genetics
  • Infectious Diseases
  • Molecular Biology
  • Physiology

Their scientific focus revolves around topics including:

  • Immunodeficiency and Autoimmune Disorders
  • Virus-based gene therapy research
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Parvovirus B19 Infection Studies
  • Adenosine and Purinergic Signaling
  • Cytomegalovirus and herpesvirus research

Best Publications

  • Activated STING in a Vascular and Pulmonary Syndrome

    Y. Liu;A.A. Jesus;B. Marrero;D. Yang

  • Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID).

    P Macchi;A Villa;S Giliani;M G Sacco

  • Actionable Diagnosis of Neuroleptospirosis by Next-Generation Sequencing

    Michael R. Wilson;Samia N. Naccache;Erik Samayoa;Mark Biagtan

  • Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2

    Qing Zhou;Dan Yang;Amanda K Ombrello;Andrey V Zavialov

  • Engraftment potential of human amnion and chorion cells derived from term placenta

    Marco Bailo;Maddalena Soncini;Elsa Vertua;Patrizia Bonassi Signoroni

  • The altered landscape of the human skin microbiome in patients with primary immunodeficiencies

    Julia Oh;Alexandra F. Freeman;Nisc Comparative Sequencing Program;Morgan Park

  • Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.

    Linda Mesler Muul;Laura M. Tuschong;Sherry Lau Soenen;G. Jayashree Jagadeesh

  • Gene therapy for adenosine deaminase–deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

    Fabio Candotti;Kit L. Shaw;Linda Muul;Denise Carbonaro

  • How I treat ADA deficiency

    H. Bobby Gaspar;Alessandro Aiuti;Fulvio Porta;Fabio Candotti

  • Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapy.

    Laura Tuschong;Sherry L. Soenen;R. Michael Blaese;Fabio Candotti

  • Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

    Chantal Lagresle-Peyrou;Chantal Lagresle-Peyrou;Chantal Lagresle-Peyrou;Emmanuelle M Six;Emmanuelle M Six;Capucine Picard;Frédéric Rieux-Laucat;Frédéric Rieux-Laucat

  • Somatic mosaicism in Wiskott–Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism

    Taizo Wada;Shepherd H. Schurman;Makoto Otsu;Elizabeth K. Garabedian

  • Mutation Analysis of IL2RG in Human X-Linked Severe Combined Immunodeficiency

    Jennifer M. Puck;Amy E. Pepper;Paula S. Henthorn;Fabio Candotti

  • Structural and functional basis for JAK3-deficient severe combined immunodeficiency.

    Fabio Candotti;Scott A. Oakes;James A. Johnston;Silvia Giliani

  • Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome.

    Fabio Candotti

  • Gene therapy: X-SCID transgene leukaemogenicity.

    Adrian J. Thrasher;Adrian J. Thrasher;H. Bobby Gaspar;H. Bobby Gaspar;Christopher Baum;Christopher Baum;Ute Modlich

  • Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency.

    Donald B. Kohn;Claire Booth;Kit L. Shaw;Jinhua Xu-Bayford

  • Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.

    Marko Pesu;Fabio Candotti;Matthew Husa;Sigrun R. Hofmann

  • Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: Evidence for interactions between the kinase and pseudokinase domains

    Min Chen;Alan Cheng;Fabio Candotti;Yong Jie Zhou

  • American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells.

    Donald B. Kohn;Michel Sadelain;Cynthia Dunbar;David Bodine

  • A novel form of complete IL-12/IL-23 receptor β1 deficiency with cell surface-expressed nonfunctional receptors

    Claire Fieschi;Marita Bosticardo;Ludovic De Beaucoudrey;Stéphanie Boisson-Dupuis

  • Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

    Scott A. Oakes;Scott A. Oakes;Fabio Candotti;James A. Johnston;Yi-Qing Chen

Frequent Co-Authors

Donald B. Kohn
Donald B. Kohn University of California, Los Angeles
Luigi D. Notarangelo
Luigi D. Notarangelo National Institutes of Health
John J. O'Shea
John J. O'Shea National Institutes of Health
Michael S. Hershfield
Michael S. Hershfield Duke University
Adrian J. Thrasher
Adrian J. Thrasher University College London
R. Michael Blaese
R. Michael Blaese National Institutes of Health
Anna Villa
Anna Villa National Academies of Sciences, Engineering, and Medicine
Silvia Giliani
Silvia Giliani University of Brescia
Rebecca H. Buckley
Rebecca H. Buckley Duke University
Jennifer M. Puck
Jennifer M. Puck University of California, San Francisco

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