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Overview

Matthias Barz is affiliated with Johannes Gutenberg University of Mainz in Germany and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Materials Science. Their research spans several subfields including Molecular Biology, Organic Chemistry, Biomaterials, Biomedical Engineering, and Immunology.

The main research topics addressed by Barz include RNA Interference and Gene Delivery, Nanoparticle-Based Drug Delivery, Advanced Biosensing and Bioanalysis Techniques, Click Chemistry and Applications, Advanced Polymer Synthesis and Characterization, Chemical Synthesis and Analysis, and Monoclonal and Polyclonal Antibodies Research.

Barz has published multiple papers in prominent venues with a focus on nanoparticle delivery systems and protein corona effects. Notable recent papers include:

  • Concepts and Approaches to Reduce or Avoid Protein Corona Formation on Nanoparticles: Challenges and Opportunities, 2024, Advanced Science
  • Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells, 2021, ACS Nano
  • Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle-Cell Interactions, 2020, Small
  • Polymeric Nanoparticles with Neglectable Protein Corona, 2020, Small
  • Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery, 2020, ACS Applied Nano Materials

Frequent co-authors in Barz's work include:

  • Heyang Zhang
  • Kaloian Koynov
  • Tobias Bauer
  • Gabriela Schäfer
  • Mustafa Diken

The scientist has contributed multiple publications to several key journals and venues over their career, with the most frequent being:

  • Macromolecular Rapid Communications (8 publications)
  • Small (6 publications)
  • Nuclear Medicine and Biology (5 publications)
  • ACS Nano (3 publications)
  • Journal of Controlled Release (3 publications)

Matthias Barz's research strongly emphasizes the synthesis and characterization of advanced polymers, the interaction of nanoparticles with biological systems, and targeted delivery methods. The combination of expertise in molecular biology and material science underpins their investigations into reducing biological interference in drug delivery systems, particularly through the modulation of protein corona formation on nanoparticles.

Best Publications

  • Core-crosslinked polymeric micelles: principles, preparation, biomedical applications and clinical translation

    Marina Talelli;Matthias Barz;Cristianne J.F. Rijcken;Fabian Kiessling

  • Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

    Matthias Barz;Robert Luxenhofer;Rudolf Zentel;María J. Vicent

  • Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

    Alexander Birke;Jun Ling;Matthias Barz

  • Ligand density on nanoparticles: A parameter with critical impact on nanomedicine.

    Alaaldin M. Alkilany;Alaaldin M. Alkilany;Lin Zhu;Horst Weller;Alf Mews

  • Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery

    Sara S. Nogueira;Anne Schlegel;Konrad Maxeiner;Benjamin Weber

  • Polypeptoid-block-polypeptide Copolymers: Synthesis, Characterization, and Application of Amphiphilic Block Copolypept(o)ides in Drug Formulations and Miniemulsion Techniques

    Alexander Birke;David Huesmann;Annette Kelsch;Martin Weilbächer

  • Polymeric Nanoparticles with Neglectable Protein Corona

    Irina Alberg;Stefan Kramer;Meike Schinnerer;Qizhi Hu

  • Nanomedicine and macroscale materials in immuno-oncology.

    Qingxue Sun;Matthias Barz;Bruno G. De Geest;Mustafa Diken

  • A controlled and versatile NCA polymerization method for the synthesis of polypeptides

    Inmaculada Conejos-Sánchez;Aroa Duro-Castano;Alexander Birke;Matthias Barz

  • From Defined Reactive Diblock Copolymers to Functional HPMA-Based Self-Assembled Nanoaggregates

    M. Barz;M. Tarantola;K. Fischer;M. Schmidt

  • Radioactive labeling of defined HPMA-based polymeric structures using [18F]FETos for in vivo imaging by positron emission tomography.

    Matthias M Herth;Matthias Barz;Dorothea Moderegger;Mareli Allmeroth

  • The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells

    Matthias Barz;Robert Luxenhofer;Rudolf Zentel;Alexander V. Kabanov

  • Influence of Binding-Site Density in Wet Bioadhesion

    Jijun Wang;Muhammad Nawaz Tahir;Michael Kappl;Wolfgang Tremel

  • Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models

    Federico Fenaroli;Urska Repnik;Yitian Xu;Kerstin Johann

  • Polypept(o)ides: Hybrid Systems Based on Polypeptides and Polypeptoids

    Kristina Klinker;Matthias Barz

  • Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation

    Benjamin Weber;Alexander Birke;Karl Fischer;Manfred Schmidt

  • Cylindrical Brush Polymers with Polysarcosine Side Chains: A Novel Biocompatible Carrier for Biomedical Applications

    Christian Hörtz;Alexander Birke;Leonard Kaps;Sandra Decker

  • Revisiting Secondary Structures in NCA Polymerization: Influences on the Analysis of Protected Polylysines

    David Huesmann;Alexander Birke;Kristina Klinker;Stephan Türk

  • Coordinative Binding of Polymers to Metal-Organic Framework Nanoparticles for Control of Interactions at the Biointerface.

    Andreas Zimpel;Nader Al Danaf;Benjamin Steinborn;Jasmin Kuhn

  • Introducing PeptoPlexes: polylysine-block-polysarcosine based polyplexes for transfection of HEK 293T cells.

    Philipp Heller;Alexander Birke;David Huesmann;Benjamin Weber

Frequent Co-Authors

Rudolf Zentel
Rudolf Zentel Johannes Gutenberg University of Mainz
Kaloian Koynov
Kaloian Koynov Max Planck Institute for Polymer Research
Twan Lammers
Twan Lammers RWTH Aachen University
Manfred Schmidt
Manfred Schmidt Johannes Gutenberg University of Mainz
Wolfgang Tremel
Wolfgang Tremel Johannes Gutenberg University of Mainz
Fabian Kiessling
Fabian Kiessling RWTH Aachen University
María J. Vicent
María J. Vicent Cardiff University
Patrick Theato
Patrick Theato Karlsruhe Institute of Technology
Ernst Wagner
Ernst Wagner Ludwig-Maximilians-Universität München
Katharina Landfester
Katharina Landfester Max Planck Institute for Polymer Research

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