World's Best Scientists 2026 revealed!
Naoki Yamamoto

Naoki Yamamoto

D-Index & Metrics

Microbiology

D-Index
95
Citations
34384
World Ranking
535
National Ranking
16

Medicine

D-Index
97
Citations
35741
World Ranking
9261
National Ranking
246

Overview

Naoki Yamamoto is affiliated with Kyoto University in Japan and has contributed extensively to the field of Medicine, with a focus on infectious diseases, epidemiology, genetics, surgery, and molecular biology. Their research portfolio includes significant work on SARS-CoV-2 and COVID-19, alongside studies related to liver disease, respiratory viral infections, venous thromboembolism, acute ischemic stroke, and cancer metabolism under hypoxic conditions.

The most frequent publication venues for Yamamoto include:

  • arXiv (Cornell University)
  • Cureus
  • Scientific Reports
  • Biochemical and Biophysical Research Communications
  • Bioorganic & Medicinal Chemistry

Frequent coauthors in Yamamoto's research career include:

  • Hajime Ikenouchi
  • Kunitada Shimotohno
  • Masashi Mizokami
  • Shin Urai
  • Genzo Iguchi

Their published papers highlight a focus on viral infections and COVID-19 genetics, with key recent works such as:

  • "Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype," 2020, Gene
  • "VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration," 2020, Scientific Reports
  • "Apparent difference in fatalities between Central Europe and East Asia due to SARS-COV-2 and COVID-19: Four hypotheses for possible explanation," 2020, Medical Hypotheses
  • "Angiotensin-Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms," 2021, Genes

Main research topics addressed in Yamamoto's publications include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Liver Disease Diagnosis and Treatment
  • Respiratory viral infections research
  • Venous Thromboembolism Diagnosis and Management
  • Acute Ischemic Stroke Management
  • Cancer, Hypoxia, and Metabolism

The scientist's work integrates genetic and molecular approaches to elucidate disease mechanisms, particularly emphasizing the viral pathogenesis of COVID-19 and its clinical phenotypes. Yamamoto's research often intersects with epidemiological data to explore variations in disease outcomes across populations, contributing to a deeper understanding of infectious diseases at both molecular and population health levels.

Best Publications

  • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.

    Tatsuya Saitoh;Naonobu Fujita;Myoung Ho Jang;Satoshi Uematsu

  • IL-6 and Its Soluble Receptor Orchestrate a Temporal Switch in the Pattern of Leukocyte Recruitment Seen during Acute Inflammation

    Suzanne Maria Hurst;Thomas S. Wilkinson;Rachel Mary McLoughlin;Suzanne Jones

  • Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

    Tatsuya Saitoh;Naonobu Fujita;Takuya Hayashi;Keigo Takahara

  • Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.

    Tatsuya Saitoh;Jun Komano;Yasunori Saitoh;Takuma Misawa

  • The soluble interleukin 6 receptor: mechanisms of production and implications in disease

    Simon A. Jones;Sankichi Horiuchi;Nicholas Topley;Naoki Yamamoto

  • Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

    Masahiro Yamamoto;Soh Yamazaki;Satoshi Uematsu;Shintaro Sato

  • Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis

    Masahiro Shuda;Nobuo Kondoh;Nobuo Imazeki;Kenji Tanaka

  • A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

    Tsutomu Murakami;Toshihiro Nakajima;Yoshio Koyanagi;Kazunobu Tachibana

  • Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry

    Shiori Haga;Norio Yamamoto;Chikako Nakai-Murakami;Yoshiaki Osawa

  • A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

    Hirokazu Tamamura;Younong Xu;Toshio Hattori;Xiaoyan Zhang

  • T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer

    Hirokazu Tamamura;Akira Hori;Naoyuki Kanzaki;Kenichi Hiramatsu

  • Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1

    Tatsuya Saitoh;Adrian Tun-Kyi;Akihide Ryo;Masahiro Yamamoto

  • TWEAK Induces NF-κB2 p100 Processing and Long Lasting NF-κB Activation

    Tatsuya Saitoh;Masafumi Nakayama;Hiroyasu Nakano;Hideo Yagita

  • Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.

    E De Clercq;N Yamamoto;R Pauwels;J Balzarini

  • Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

    Mari Ann Nowell;Peter James Richards;Sankichi Horiuchi;Naoki Yamamoto

  • HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus.

    Norio Yamamoto;Rongge Yang;Yoshiyuki Yoshinaka;Shinji Amari

  • Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.

    Masahiro Yamamoto;Toru Okamoto;Kiyoshi Takeda;Shintaro Sato

  • Antiviral Protein Viperin Promotes Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Type I Interferon Production in Plasmacytoid Dendritic Cells

    Tatsuya Saitoh;Takashi Satoh;Naoki Yamamoto;Satoshi Uematsu

  • In vivo infection of human T-cell leukemia virus type I in non-T cells.

    Yoshio Koyanagi;Yasuto Itoyama;Naomi Nakamura;Keita Takamatsu

  • Hematopoietic stem cell–engrafted NOD/SCID/IL2Rγnull mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses

    Satoru Watanabe;Kazuo Terashima;Shinrai Ohta;Shigeo Horibata

  • Regioselective syntheses of sulfated polysaccharides: specific anti-HIV-1 activity of novel chitin sulfates

    Shin-Ichiro Nishimura;Hideaki Kai;Katsuhiko Shinada;Takashi Yoshida

Frequent Co-Authors

Hirokazu Tamamura
Hirokazu Tamamura Tokyo Medical and Dental University
Yoshio Koyanagi
Yoshio Koyanagi Kyoto University
Nobutaka Fujii
Nobutaka Fujii Kyoto University
Akihide Ryo
Akihide Ryo Yokohama City University
Akira Otaka
Akira Otaka University of Tokushima
Shoji Yamaoka
Shoji Yamaoka Tokyo Medical and Dental University
Yuetsu Tanaka
Yuetsu Tanaka University of the Ryukyus
Tatsuya Saitoh
Tatsuya Saitoh Osaka University
Naoki Mori
Naoki Mori University of the Ryukyus
Tetsutaro Sata
Tetsutaro Sata National Institute of Infectious Diseases

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