Toshio Hirano

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Japan Leader Award
• 2025 - Research.com Biology and Biochemistry in Japan Leader Award
• 2023 - Research.com Biology and Biochemistry in Japan Leader Award
• 2022 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Best Publications

• Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

  Toshio Hirano;Kiyoshi Yasukawa;Hisashi Harada;Tetsuya Taga

  2802
  Citations

• Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

  Michio Kawano;Toshio Hirano;Tadashi Matsuda;Tetsuya Taga

  2097
  Citations

• A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family.

  Shizuo Akira;Hiroshi Isshiki;Takahisa Sugita;Osamu Tanabe

  1851
  Citations

• Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

  Tetsuya Taga;Masahiko Hibi;Yuuichi Hirata;Katsuhiko Yamasaki

  1827
  Citations

• Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF).

  Shizuo Akira;Toshio Hirano;Tetsuya Taga;Tadamitsu Kishimoto

  1745
  Citations

• Molecular cloning and expression of an IL-6 signal transducer, gp130

  Masahiko Hibi;Masaaki Murakami;Mikiyoshi Saito;Toshio Hirano

  1664
  Citations

• Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.

  Toshio Hirano;Katsuhiko Ishihara;Masahiko Hibi

  1510
  Citations

• Biological and clinical aspects of interleukin 6.

  Toshio Hirano;Shizuo Akira;Tetsuya Taga;Tadamitsu Kishimoto

  1500
  Citations

• Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

  Katsuhiko Yamasaki;Tetsuya Taga;Yuuichi Hirata;Hideo Yawata

  1421
  Citations

• IL-6 is produced by osteoblasts and induces bone resorption.

  Y Ishimi;C Miyaura;C H Jin;T Akatsu

  1413
  Citations

• Pathogenic Significance of Interleukin-6 (IL-6/BSF-2) in Castleman's Disease

  K Yoshizaki;T Matsuda;N Nishimoto;T Kuritani

  1187
  Citations

• The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

  Atsushi Muraguchi;Toshio Hirano;Bo Tang;Tadashi Matsuda

  1080
  Citations

• IL-6 in autoimmune disease and chronic inflammatory proliferative disease.

  Katsuhiko Ishihara;Toshio Hirano

  1060
  Citations

• Interleukin 6 and its receptor: ten years later.

  Toshio Hirano

  1014
  Citations

• Excessive production of interleukin 6/B cell stimulatory factor‐2 in rheumatoid arthritis

  T Hirano;T Matsuda;M Turner;N Miyasaka

  1006
  Citations

• IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.

  Hideo Yasukawa;Masanobu Ohishi;Hiroyuki Mori;Masaaki Murakami

  960
  Citations

• Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

  Toshio Hirano;Tetsuya Taga;Naoko Nakano;Kiyosi Yasukawa

  951
  Citations

• Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

  Toshiyuki Fukada;Masahiko Hibi;Yojiro Yamanaka;Mariko Takahashi-Tezuka

  856
  Citations

• IL-6 signal transduction and its physiological roles: the signal orchestration model

  D. Kamimura;K. Ishihara;T. Hirano

  855
  Citations

• Molecular Regulation of B Lymphocyte Response

  Tadamitsu Kishimoto;Toshio Hirano

  824
  Citations