World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
17378
World Ranking
12959
National Ranking
898

Overview

Naoko Arai is affiliated with the University of Tokyo in Japan and focuses on research primarily within the field of Medicine. Their work spans several subfields, including Molecular Biology, Cell Biology, Epidemiology, Leadership and Management, and Physiology.

Their scholarly contributions cover a range of topics reflecting a diverse research portfolio. The main subjects investigated include:

  • Ubiquitin and proteasome pathways
  • Endoplasmic Reticulum Stress and Disease
  • Autophagy in Disease and Therapy
  • Healthcare Education and Workforce Issues
  • Simulation-Based Education in Healthcare
  • Delphi Technique in Research
  • Esophageal and GI Pathology

Naoko Arai has coauthored research with several colleagues, notably Akinori Endo, Sayaka Yasuda, Hikaru Tsuchiya, Ai Kaiho, and Qiang Guo. The collaboration frequency indicates a strong working relationship especially with Akinori Endo.

Their publications appear consistently across multiple scholarly venues, illustrating a multidisciplinary approach. The frequent publication venues include:

  • Nature
  • Journal of Japan Academy of Nursing Science
  • Progress of Digestive Endoscopy
  • Proceedings of the National Academy of Sciences

Among their recent papers are:

  • "Stress- and ubiquitylation-dependent phase separation of the proteasome," published in 2020 in Nature
  • "Occupational Tasks and Competencies of Flight Nurses as Considered by Nurses Certified for Emergency Nursing," published in 2021 in the Journal of Japan Academy of Nursing Science
  • "Case of treatment of malignant stenosis of colostomy for gastric cancer with SEMS," published in 2023 in Progress of Digestive Endoscopy
  • "NFE2L1/Nrf1 forms a coactivator complex post-peptide: N -glycanase-mediated sequence editing and mitigates proteasome dysfunction," published in 2025 in Proceedings of the National Academy of Sciences

Best Publications

  • SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

    Y. Takebe;M. Seiki;J.-I. Fujisawa;P. Hoy

  • Cytokines: Coordinators of Immune and Inflammatory Responses

    Ken-ichi Arai;Frank Lee;Atsushi Miyajima;Shoichiro Miyatake

  • IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2

    J Pène;F Rousset;F Brière;I Chrétien

  • Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.

    T Defrance;J P Aubry;F Rousset;B Vanbervliet

  • The molecular basis of T helper 1 and T helper 2 cell differentiation.

    Anne O’Garra;Naoko Arai

  • Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

    Hyun Jun Lee;Naofumi Takemoto;Hirokazu Kurata;Yumiko Kamogawa

  • Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells

    Takashi Yokota;Frank Lee;Donna Rennick;Carol Hall

  • Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells

    Hirokazu Kurata;Hyun Jun Lee;Anne O'Garra;Naoko Arai

  • Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.

    Josh Gregorio;Josh Gregorio;Stephan Meller;Curdin Conrad;Anna Di Nardo

  • Recombinant interleukin 4 promotes the growth of human T cells.

    H. Spits;H. Yssel;Y. Takebe;N. Arai

  • NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.

    Esteban S. Masuda;Yoshiyuki Naito;Hiroshi Tokumitsu;Dave Campbell

  • Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells.

    Donna Rennick;Gloria Yang;Christa Muller-Sieburg;Craig Smith

  • Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells

    T Yokota;N Arai;J de Vries;H Spits

  • Molecular basis for heterogeneity of the human p53 protein.

    N Harris;E Brill;O Shohat;M Prokocimer

  • Stress- and ubiquitylation-dependent phase separation of the proteasome

    Sayaka Yasuda;Hikaru Tsuchiya;Ai Kaiho;Qiang Guo

  • GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels

    Iris A. Ferber;Hyun-Jun Lee;Francesca Zonin;Victoria Heath

  • Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4).

    T R Mosmann;T Yokota;R Kastelein;S M Zurawski

  • Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster

    Naofumi Takemoto;Yumiko Kamogawa;Hyun Jun Lee;Hirokazu Kurata

  • Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

    Takashi Yokota;Naoko Arai;Frank Lee;Donna Rennick

  • Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

    Naofumi Takemoto;Naoko Koyano-Nakagawa;Takashi Yokota;Naoko Arai

Frequent Co-Authors

Ken-ichi Arai
Ken-ichi Arai University of Tokyo
Takashi Yokota
Takashi Yokota Kanazawa University
Yoshito Kaziro
Yoshito Kaziro Kyoto University
Anne O'Garra
Anne O'Garra The Francis Crick Institute
Donna Rennick
Donna Rennick MSD (United States)
Frank S. Lee
Frank S. Lee University of Pennsylvania
Atsushi Miyajima
Atsushi Miyajima University of Tokyo
Hiroshi Tokumitsu
Hiroshi Tokumitsu Okayama University
Yutaka Takebe
Yutaka Takebe National Institute of Infectious Diseases

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