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Hiroshi Tokumitsu

Hiroshi Tokumitsu

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
9239
World Ranking
18652
National Ranking
1336

Overview

Hiroshi Tokumitsu is affiliated with Okayama University in Japan and has contributed to the field of Biochemistry, Genetics, and Molecular Biology with a focus on Molecular Biology. Their work spans several subfields including Immunology, Surgery, Cell Biology, and Physiology.

Their research covers a variety of topics, primarily:

  • Protein Kinase Regulation and GTPase Signaling
  • Metabolism, Diabetes, and Cancer
  • Pancreatic function and diabetes
  • S100 Proteins and Annexins
  • Ion channel regulation and function
  • Vitamin K Research Studies
  • Immune Response and Inflammation

Key publications by Hiroshi Tokumitsu include:

  • Molecular Mechanisms Underlying Ca2+/Calmodulin-Dependent Protein Kinase Kinase Signal Transduction (2022), published in International Journal of Molecular Sciences
  • Regulation of the tubulin polymerization-promoting protein by Ca2+/S100 proteins (2021), published in Cell Calcium
  • A temporal Ca2+ desensitization of myosin light chain kinase in phasic smooth muscles induced by CaMKKβ/PP2A pathways (2021), published in American Journal of Physiology-Cell Physiology
  • Development and Characterization of Novel Molecular Probes for Ca2+/Calmodulin-Dependent Protein Kinase Kinase, Derived from STO-609 (2020), published in Biochemistry
  • Oligomerization of Ca2+/calmodulin-dependent protein kinase kinase (2021), published in Biochemical and Biophysical Research Communications

Frequent co-authors collaborating with Tokumitsu include:

  • Masaki Magari
  • Satomi Ohtsuka
  • Naoya Hatano
  • Naoki Kanayama
  • Hiroyuki Sakagami

The scientist's research has appeared in several recurring publication venues, such as:

  • Biochemical and Biophysical Research Communications
  • Biochemistry
  • Cell Calcium
  • FEBS Letters
  • Biomolecules

Best Publications

  • KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II

    Hiroshi Tokumitsu;Takashi Chijiwa;Masatoshi Hagiwara;Akihiro Mizutani

  • Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

    Shigetoshi Yano;Hiroshi Tokumitsu;Thomas R. Soderling

  • Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

    Gary A. Wayman;Yong-Seok Lee;Hiroshi Tokumitsu;Alcino J. Silva

  • STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase

    Hiroshi Tokumitsu;Hiroyuki Inuzuka;Yumi Ishikawa;Masahiko Ikeda

  • Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade

    Hervé Enslen;Hiroshi Tokumitsu;Philip J.S. Stork;Roger J. Davis

  • Characterization of a Ca2+/calmodulin-dependent protein kinase cascade: Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase

    Hiroshi Tokumitsu;Hervé Enslen;Thomas R. Soderling

  • A novel target recognition revealed by calmodulin in complex with Ca2+-calmodulin-dependent kinase kinase.

    Masanori Osawa;Hiroshi Tokumitsu;Mark B. Swindells;Hiroyuki Kurihara

  • NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.

    Esteban S. Masuda;Yoshiyuki Naito;Hiroshi Tokumitsu;Dave Campbell

  • Regulation of Axonal Extension and Growth Cone Motility by Calmodulin-Dependent Protein Kinase I

    Gary A. Wayman;Stefanie Kaech;Wilmon F. Grant;Monika Davare

  • Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.

    Hiroshi Tokumitsu;Debra A. Brickey;John Glod;Hiroyoshi Hidaka

  • Requirements for Calcium and Calmodulin in the Calmodulin Kinase Activation Cascade

    Hiroshi Tokumitsu;Thomas R. Soderling

  • Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51.

    Jin Yan;Hidehito Kuroyanagi;Asato Kuroiwa;Yo Ichi Matsuda

  • Analysis of CaM-kinase Signaling in Cells

    Gary A. Wayman;Hiroshi Tokumitsu;Monika A. Davare;Thomas R. Soderling

  • A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.

    Yoshishige Kimura;Ethan E. Corcoran;Koh Eto;Keiko Gengyo-Ando

  • The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT.

    E. S. Masuda;H. Tokumitsu;A. Tsuboi;J. Shlomai

  • Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca(2+)/calmodulin-dependent kinase kinase peptide

    Hirofumi Kurokawa;Masanori Osawa;Hiroyuki Kurihara;Naoko Katayama

  • A calcyclin-associated protein is a newly identified member of the Ca2+/phospholipid-binding proteins, annexin family.

    H Tokumitsu;A Mizutani;H Minami;R Kobayashi

  • Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade.

    Gary A. Wayman;Hiroshi Tokumitsu;Thomas R. Soderling

  • Phosphorylation of CREB by CaM-Kinase IV Activated by CaM-Kinase IV Kinase

    Hervé Enslen;Hiroshi Tokumitsu;T. R. Soderling

  • Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity (DOI:10.1016/j.neuron.2008.08.021)

    Gary A. Wayman;Yong Seok Lee;Hiroshi Tokumitsu;Alcino J. Silva

Frequent Co-Authors

Hiroyoshi Hidaka
Hiroyoshi Hidaka D. Western Therapeutics Institute (Japan)
Masaaki Muramatsu
Masaaki Muramatsu Tokyo Medical and Dental University
Thomas R. Soderling
Thomas R. Soderling Oregon Health & Science University
Hiroyuki Inuzuka
Hiroyuki Inuzuka Beth Israel Deaconess Medical Center
Ken-ichi Arai
Ken-ichi Arai University of Tokyo
Masatoshi Hagiwara
Masatoshi Hagiwara Kyoto University
Gary A. Wayman
Gary A. Wayman Washington State University
Hiroyuki Sakagami
Hiroyuki Sakagami Kitasato University
Naoko Arai
Naoko Arai University of Tokyo
Mitsuhiko Ikura
Mitsuhiko Ikura Princess Margaret Cancer Centre

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