Hiroshi Tokumitsu mainly focuses on Molecular biology, Ca2+/calmodulin-dependent protein kinase, Biochemistry, Mitogen-activated protein kinase kinase and Cyclin-dependent kinase 9. His biological study spans a wide range of topics, including Binding protein and Transcription factor. His work investigates the relationship between Ca2+/calmodulin-dependent protein kinase and topics such as Calmodulin that intersect with problems in Cell biology, CAMK, Kinase and Peptide.
His work in the fields of Biochemistry, such as Peptide sequence, Gel electrophoresis, Phosphatidylinositol and Annexin, overlaps with other areas such as Phosphatidylethanolamine. He interconnects MAP kinase kinase kinase and MAP2K7 in the investigation of issues within Mitogen-activated protein kinase kinase. His studies deal with areas such as Casein kinase 2 and Kinase activity as well as Cyclin-dependent kinase 9.
Hiroshi Tokumitsu mostly deals with Cell biology, Molecular biology, Biochemistry, Protein kinase A and Calmodulin. His Molecular biology research is multidisciplinary, incorporating elements of Myosin light-chain kinase, Transcription factor, Complementary DNA, Annexin and Monoclonal antibody. His study in Mitogen-activated protein kinase kinase, MAP2K7, Cyclin-dependent kinase 2, Cyclin-dependent kinase 9 and MAP kinase kinase kinase is carried out as part of his Biochemistry studies.
His research integrates issues of cGMP-dependent protein kinase and Kinase activity in his study of Cyclin-dependent kinase 9. His work on AMPK is typically connected to Synapsin I as part of general Protein kinase A study, connecting several disciplines of science. His Calmodulin research includes themes of Binding protein, Immunoprecipitation, Biophysics, Transfection and Activator.
Cell biology, Phosphorylation, Somatic hypermutation, Protein kinase A and Genetics are his primary areas of study. His work carried out in the field of Cell biology brings together such families of science as Cell and Transfection. His Phosphorylation study is associated with Biochemistry.
His Cyclophilin and Tetratricopeptide study, which is part of a larger body of work in Biochemistry, is frequently linked to FKBP52 and GRB10, bridging the gap between disciplines. His Protein kinase A study deals with the bigger picture of Kinase. In his study, which falls under the umbrella issue of Protein–protein interaction, Molecular biology is strongly linked to Calmodulin.
The scientist’s investigation covers issues in Cell biology, Protein kinase A, Phosphorylation, Molecular biology and AMPK. His work is dedicated to discovering how Cell biology, Biochemistry are connected with Calcium-binding protein and other disciplines. His Protein kinase A research is multidisciplinary, incorporating perspectives in Cell culture, Signal transduction and Mutant.
His Molecular biology study combines topics in areas such as Sequence, Human proteins, Recombinant DNA and Function. His AMPK research integrates issues from Transport protein, Autophosphorylation, Adenylate kinase and Calmodulin. Hiroshi Tokumitsu combines subjects such as Cyclin-dependent kinase 9, MAP2K7 and MAP kinase kinase kinase with his study of ASK1.
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KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II
Hiroshi Tokumitsu;Takashi Chijiwa;Masatoshi Hagiwara;Akihiro Mizutani.
Journal of Biological Chemistry (1990)
Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
Shigetoshi Yano;Hiroshi Tokumitsu;Thomas R. Soderling.
Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity
Gary A. Wayman;Yong-Seok Lee;Hiroshi Tokumitsu;Alcino J. Silva.
STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase
Hiroshi Tokumitsu;Hiroyuki Inuzuka;Yumi Ishikawa;Masahiko Ikeda.
Journal of Biological Chemistry (2002)
Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
Hervé Enslen;Hiroshi Tokumitsu;Philip J.S. Stork;Roger J. Davis.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Characterization of a Ca2+/calmodulin-dependent protein kinase cascade: Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase
Hiroshi Tokumitsu;Hervé Enslen;Thomas R. Soderling.
Journal of Biological Chemistry (1995)
NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus.
Esteban S. Masuda;Yoshiyuki Naito;Hiroshi Tokumitsu;Dave Campbell.
Molecular and Cellular Biology (1995)
Regulation of Axonal Extension and Growth Cone Motility by Calmodulin-Dependent Protein Kinase I
Gary A. Wayman;Stefanie Kaech;Wilmon F. Grant;Monika Davare.
The Journal of Neuroscience (2004)
Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.
Hiroshi Tokumitsu;Debra A. Brickey;John Glod;Hiroyoshi Hidaka.
Journal of Biological Chemistry (1994)
Requirements for Calcium and Calmodulin in the Calmodulin Kinase Activation Cascade
Hiroshi Tokumitsu;Thomas R. Soderling.
Journal of Biological Chemistry (1996)
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