What is he best known for?
The fields of study he is best known for:
Hiroshi Tokumitsu mainly focuses on Molecular biology, Ca2+/calmodulin-dependent protein kinase, Biochemistry, Mitogen-activated protein kinase kinase and Cyclin-dependent kinase 9.
His biological study spans a wide range of topics, including Binding protein and Transcription factor.
His work investigates the relationship between Ca2+/calmodulin-dependent protein kinase and topics such as Calmodulin that intersect with problems in Cell biology, CAMK, Kinase and Peptide.
His work in the fields of Biochemistry, such as Peptide sequence, Gel electrophoresis, Phosphatidylinositol and Annexin, overlaps with other areas such as Phosphatidylethanolamine.
He interconnects MAP kinase kinase kinase and MAP2K7 in the investigation of issues within Mitogen-activated protein kinase kinase.
His studies deal with areas such as Casein kinase 2 and Kinase activity as well as Cyclin-dependent kinase 9.
His most cited work include:
- KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (575 citations)
- Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway (547 citations)
- Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity (433 citations)
What are the main themes of his work throughout his whole career to date?
Hiroshi Tokumitsu mostly deals with Cell biology, Molecular biology, Biochemistry, Protein kinase A and Calmodulin.
His Molecular biology research is multidisciplinary, incorporating elements of Myosin light-chain kinase, Transcription factor, Complementary DNA, Annexin and Monoclonal antibody.
His study in Mitogen-activated protein kinase kinase, MAP2K7, Cyclin-dependent kinase 2, Cyclin-dependent kinase 9 and MAP kinase kinase kinase is carried out as part of his Biochemistry studies.
His research integrates issues of cGMP-dependent protein kinase and Kinase activity in his study of Cyclin-dependent kinase 9.
His work on AMPK is typically connected to Synapsin I as part of general Protein kinase A study, connecting several disciplines of science.
His Calmodulin research includes themes of Binding protein, Immunoprecipitation, Biophysics, Transfection and Activator.
He most often published in these fields:
- Cell biology (48.68%)
- Molecular biology (36.84%)
- Biochemistry (38.16%)
What were the highlights of his more recent work (between 2013-2021)?
- Cell biology (48.68%)
- Phosphorylation (19.08%)
- Somatic hypermutation (5.26%)
In recent papers he was focusing on the following fields of study:
Cell biology, Phosphorylation, Somatic hypermutation, Protein kinase A and Genetics are his primary areas of study.
His work carried out in the field of Cell biology brings together such families of science as Cell and Transfection.
His Phosphorylation study is associated with Biochemistry.
His Cyclophilin and Tetratricopeptide study, which is part of a larger body of work in Biochemistry, is frequently linked to FKBP52 and GRB10, bridging the gap between disciplines.
His Protein kinase A study deals with the bigger picture of Kinase.
In his study, which falls under the umbrella issue of Protein–protein interaction, Molecular biology is strongly linked to Calmodulin.
Between 2013 and 2021, his most popular works were:
- Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators (49 citations)
- NUMB phosphorylation destabilizes p53 and promotes self-renewal of tumor-initiating cells by a NANOG-dependent mechanism in liver cancer (25 citations)
- AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β. (20 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Cell biology, Protein kinase A, Phosphorylation, Molecular biology and AMPK.
His work is dedicated to discovering how Cell biology, Biochemistry are connected with Calcium-binding protein and other disciplines.
His Protein kinase A research is multidisciplinary, incorporating perspectives in Cell culture, Signal transduction and Mutant.
His Molecular biology study combines topics in areas such as Sequence, Human proteins, Recombinant DNA and Function.
His AMPK research integrates issues from Transport protein, Autophosphorylation, Adenylate kinase and Calmodulin.
Hiroshi Tokumitsu combines subjects such as Cyclin-dependent kinase 9, MAP2K7 and MAP kinase kinase kinase with his study of ASK1.
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