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Biology and Biochemistry

D-Index
92
Citations
31970
World Ranking
2205
National Ranking
1191

Overview

Howard Schulman is affiliated with Stanford University in the United States and conducts research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their work spans a range of specialized subfields, including Molecular Biology, Cellular and Molecular Neuroscience, Cognitive Neuroscience, Cardiology and Cardiovascular Medicine, and Genetics.

Their recent publications cover several significant research topics related to neural mechanisms and molecular signaling. The main topics that Schulman focuses on include Neuroscience and Neuropharmacology Research, Protein Kinase Regulation and GTPase Signaling, Memory and Neural Mechanisms, Mitochondrial Function and Pathology, Genetics and Neurodevelopmental Disorders, Signaling Pathways in Disease, and Receptor Mechanisms and Signaling.

Noteworthy recent papers authored or co-authored by Schulman include:

  • LTP induction by structural rather than enzymatic functions of CaMKII, 2023, published in Nature
  • Synaptic memory and CaMKII, 2023, published in Physiological Reviews
  • Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation, 2020, published in eLife
  • CaMKII autophosphorylation is the only enzymatic event required for synaptic memory, 2024, published in Proceedings of the National Academy of Sciences
  • Role of CAMK2D in neurodevelopment and associated conditions, 2024, published in The American Journal of Human Genetics

Frequent co-authors collaborating with Schulman include:

  • Roger A. Nicoll
  • Danielle Veenma
  • Geeske M. van Woerden
  • Xiumin Chen
  • Qixu Cai

Schulman's work appears regularly in several scholarly venues, with multiple publications in The American Journal of Human Genetics. Other frequent publication venues include Nature, Physiological Reviews, Proceedings of the National Academy of Sciences, and eLife.

Best Publications

  • The molecular basis of CaMKII function in synaptic and behavioural memory.

    John Lisman;Howard Schulman;Hollis Cline

  • Inhibition of postsynaptic PKC or CaMKII blocks induction but not expression of LTP.

    Roberto Malinow;Howard Schulman;Richard W. Tsien

  • Sensitivity of CaM Kinase II to the Frequency of Ca2+ Oscillations

    Paul De Koninck;Howard Schulman

  • The multifunctional calcium/calmodulin-dependent protein kinase: from form to function.

    and A P Braun;H Schulman

  • Neuronal Ca2+/Calmodulin-Dependent Protein Kinases

    Phyllis I. Hanson;Howard Schulman

  • Neuronal Ca2+/Calmodulin-Dependent Protein Kinase II: The Role of Structure and Autoregulation in Cellular Function

    Andy Hudmon;Howard Schulman

  • Interaction with the NMDA receptor locks CaMKII in an active conformation

    K.-Ulrich Bayer;Paul De Koninck;Paul De Koninck;A. Soren Leonard;A. Soren Leonard;Johannes W. Hell;Johannes W. Hell

  • Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II.

    Andy Hudmon;Howard Schulman

  • Calmodulin trapping by calcium-calmodulin-dependent protein kinase.

    Tobias Meyer;Phyllis I. Hanson;Lubert Stryer;Howard Schulman

  • Global changes to the ubiquitin system in Huntington's disease

    Eric J. Bennett;Thomas A. Shaler;Ben Woodman;Kwon-Yul Ryu

  • Dual role of calmodulin in autophosphorylation of multifunctional cam kinase may underlie decoding of calcium signals

    Phyllis I. Hanson;Tobias Meyer;Lubert Stryer;Howard Schulman

  • Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

    Howard Schulman;Paul Greengard

  • Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein

    Howard Schulman;Paul Greengard

  • Selective Regulation of Neurite Extension and Synapse Formation by the β but not the α Isoform of CaMKII

    Charles C Fink;Karl-Ulrich Bayer;Jason W Myers;James E Ferrell

  • CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation.

    Andy Hudmon;Howard Schulman;James Kim;Janet M. Maltez

  • Alternative splicing introduces a nuclear localization signal that targets multifunctional CaM kinase to the nucleus.

    Mallika Srinivasan;Carl E Edman;Howard Schulman

  • Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels

    Geoffrey S. Pitt;Roger D. Zühlke;Andy Hudmon;Howard Schulman

  • The human mu opioid receptor: modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C

    Anton Mestek;Joyce H. Hurley;Leighan S. Bye;Andrew D. Campbell

  • Expression of a multifunctional Ca2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation.

    Phyllis I. Hanson;Michael S. Kapiloff;Lillian L. Lou;Michael G. Rosenfeld

  • Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase.

    Chijen R. Lin;Michael S. Kapiloff;Sally Durgerian;Kazuhiko Tatemoto

Frequent Co-Authors

John Kuriyan
John Kuriyan Vanderbilt University
Richard W. Tsien
Richard W. Tsien New York University
Jay T. Groves
Jay T. Groves University of California, Berkeley
Tobias Meyer
Tobias Meyer Stanford University
Mark E. Anderson
Mark E. Anderson Johns Hopkins University
Johannes W. Hell
Johannes W. Hell University of California, Davis
Lubert Stryer
Lubert Stryer Stanford University
John A. Wagner
John A. Wagner Cygnal Therapeutics (United States)
Roberto Malinow
Roberto Malinow University of California, San Diego

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