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Biology and Biochemistry
USA
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
143
Citations
63613
World Ranking
242
National Ranking
165

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

Angus C. Nairn is affiliated with Yale University in the United States. Their research broadly spans biochemistry, genetics, molecular biology, neuroscience, and medicine, with significant work published across these intersecting fields.

The scientist's primary subfields of study include molecular biology, physiology, cellular and molecular neuroscience, spectroscopy, and neurology. Their research topics cover a range of specialized areas such as Alzheimer's disease research and treatments, metabolomics and mass spectrometry studies, advanced proteomics techniques and applications, neuroscience and neuropharmacology research, tryptophan and brain disorders, mitochondrial function and pathology, and mechanisms related to neuroinflammation and neurodegeneration.

Among the recent research papers authored or co-authored by Angus C. Nairn are the following:

  • Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease (2021), published in Alzheimer's & Dementia
  • Age-related calcium dysregulation linked with tau pathology and impaired cognition in non-human primates (2021), published in Alzheimer's & Dementia
  • Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex (2020), published in Journal of Neuroinflammation
  • Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability (2021), published in Science Advances
  • Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics (2021), published in Neurobiology of Aging

Angus C. Nairn frequently collaborates with several researchers, including:

  • Shannon Leslie
  • TuKiet T. Lam
  • Shveta Bathla
  • Becky C. Carlyle
  • Steven E. Arnold

The scientist's work has been published predominantly in venues such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia, Frontiers in Aging Neuroscience, and Research Square. These platforms have been the primary outlets for disseminating their research findings.

Best Publications

  • Regulation of NMDA receptor trafficking by amyloid-beta.

    Eric M Snyder;Yi Nong;Claudia G Almeida;Surojit Paul

  • Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1.

    Jonathan Goldberg;Hsien Bin Huang;Young Guen Kwon;Paul Greengard

  • Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.

    Paul Greengard;Patrick B. Allen;Angus C. Nairn

  • MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.

    J. H. Hartwig;M. Thelen;M. Thelen;A. Resen;P. A. Janmey

  • DARPP-32: an integrator of neurotransmission.

    Per Svenningsson;Akinori Nishi;Gilberto Fisone;Jean-Antoine Girault

  • Integrative functional genomic analysis of human brain development and neuropsychiatric risks

    Mingfeng Li;Gabriel Santpere;Yuka Imamura Kawasawa;Yuka Imamura Kawasawa;Oleg V Evgrafov

  • Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum

    Emmanuel Valjent;Vincent Pascoli;Per Svenningsson;Surojit Paul

  • PKC-alpha regulates cardiac contractility and propensity toward heart failure.

    Julian C Braz;Kimberly Gregory;Anand Pathak;Wen Zhao

  • Protein phosphatases: recent progress.

    S. Shenolikar;A. C. Nairn

  • Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons

    D.James Surmeier;Jose Bargas;Hugh C Hemmings;Hugh C Hemmings;Angus C Nairn

  • Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

    James A. Bibb;Gretchen L. Snyder;Akinori Nishi;Zhen Yan

  • Protein Kinases in the Brain

    Nairn Ac;Hemmings Hc;Greengard P

  • Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

    James A. Bibb;Jingshan Chen;Jane R. Taylor;Per Svenningsson

  • Control of CFTR Channel Gating by Phosphorylation and Nucleotide Hydrolysis

    David C. Gadsby;Angus C. Nairn

  • Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons.

    Paul Greengard;Joanna Jen;Angus C. Nairn;Charles F. Stevens

  • CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains

    Paola Vergani;Steve W. Lockless;Angus C. Nairn;Angus C. Nairn;David C. Gadsby

  • CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

    Xiao Jian Han;Yun Fei Lu;Shun Ai Li;Taku Kaitsuka

  • Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

    A C Nairn;H C Palfrey

  • Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane.

    Marcus Thelen;Antony Rosen;Angus C. Nairn;Alan Aderem

  • Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia

    Vincent F. Castellucci;Eric R. Kandel;James H. Schwartz;Frank D. Wilson

Frequent Co-Authors

Paul Greengard
Paul Greengard Rockefeller University
Akinori Nishi
Akinori Nishi Kurume University
Andrew J. Czernik
Andrew J. Czernik PhosphoSolutions
Paul J. Lombroso
Paul J. Lombroso Yale University
Marina R. Picciotto
Marina R. Picciotto Yale University
Toshiharu Suzuki
Toshiharu Suzuki Hokkaido University
Kenneth R. Williams
Kenneth R. Williams Yale University
Allen A. Fienberg
Allen A. Fienberg Rockefeller University
Per Svenningsson
Per Svenningsson Karolinska Institute

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