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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
66046
World Ranking
1480
National Ranking
88

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

David Carling is affiliated with Imperial College London in the United Kingdom. Their work spans several interconnected fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a broader focus on Molecular Biology, Surgery, Epidemiology, Endocrinology, Diabetes and Metabolism, and Physiology.

The scientist's research prominently covers topics related to Metabolism, Diabetes, and Cancer, Pancreatic function and diabetes, Diabetes Treatment and Management, Adipose Tissue and Metabolism, Liver Disease Diagnosis and Treatment, Regulation of Appetite and Obesity, and Adipokines, Inflammation, and Metabolic Diseases.

David Carling's recent publications include:

  • Inhibition of IL-11 signalling extends mammalian healthspan and lifespan, 2024, Nature
  • Indisulam targets RNA splicing and metabolism to serve as a therapeutic strategy for high-risk neuroblastoma, 2022, Nature Communications
  • Direct AMPK Activation Corrects NASH in Rodents Through Metabolic Effects and Direct Action on Inflammation and Fibrogenesis, 2021, Hepatology Communications
  • Cell competition acts as a purifying selection to eliminate cells with mitochondrial defects during early mouse development, 2021, Nature Metabolism
  • Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK, 2020, Inflammatory Bowel Diseases

The scientist frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Metabolism
  • Biochemical Journal
  • Nature
  • Nature Metabolism

Frequent co-authors of David Carling include Anissa A. Widjaja, Stuart A. Cook, Alice Pollard, Stephen R. Bloom, and Tricia Tan. Each of these collaborators has co-authored multiple papers with David Carling, demonstrating ongoing collaborative research efforts.

Best Publications

  • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

    T Yamauchi;J Kamon;Y Minokoshi;Y Ito

  • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

    Barbara B. Kahn;Thierry Alquier;David Carling;D. Grahame Hardie

  • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.

    Yasuhiko Minokoshi;Young-Bum Kim;Odile D. Peroni;Lee G. D. Fryer

  • The AMP‐Activated Protein Kinase

    D. Grahame Hardie;David Carling

  • LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

    Angela Woods;Stephen R. Johnstone;Kristina Dickerson;Fiona C. Leiper

  • The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

    D G Hardie;D Carling;M Carlson

  • Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

    Simon A. Hawley;Matthew Davison;Angela Woods;Stephen P. Davies

  • Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

    Angela Woods;Kristina Dickerson;Richard Heath;Seung-Pyo Hong

  • The AMP-activated protein kinase cascade-a unifying system for energy control

    David Carling

  • The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways

    Lee G.D. Fryer;Asha Parbu-Patel;David Carling

  • Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

    Colin Selman;Jennifer M A Tullet;Daniela Wieser;Elaine Elizabeth Irvine

  • Structure of mammalian AMPK and its regulation by ADP

    Bing Xiao;Matthew J. Sanders;Matthew J. Sanders;Elizabeth Underwood;Richard J. Heath

  • Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia.

    A S Marsin;L Bertrand;M H Rider;J Deprez

  • Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

    T. A. J. Haystead;A. T. R. Sim;D. Carling;R. C. Honnor

  • AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

    Ulrika Andersson;Karin Filipsson;Caroline R. Abbott;Angela Woods

  • AMPK, insulin resistance, and the metabolic syndrome.

    Neil B. Ruderman;David Carling;Marc Prentki;José M. Cacicedo

  • Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.

    P C Cheung;I P Salt;I P Salt;S P Davies;D G Hardie

  • Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

    Duygu Sag;David Carling;Robert D. Stout;Jill Suttles

  • Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

    Matthew J. Sanders;Pascal O. Grondin;Bronwyn D. Hegarty;Michael A. Snowden

  • AMPK signalling in health and disease.

    David Carling

Frequent Co-Authors

D. Grahame Hardie
D. Grahame Hardie University of Dundee
Benoit Viollet
Benoit Viollet Institut Cochin
Dorian O. Haskard
Dorian O. Haskard Imperial College London
Joseph J. Boyle
Joseph J. Boyle Imperial College London
Hugh Watkins
Hugh Watkins University of Oxford
Dominic J. Withers
Dominic J. Withers Imperial College London
Marian Carlson
Marian Carlson Howard Hughes Medical Institute
Steven J. Gamblin
Steven J. Gamblin The Francis Crick Institute
James C. Scott
James C. Scott Yale University
Charles Redwood
Charles Redwood University of Oxford

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