Charles Redwood

Overview

Best Publications

• Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

  Edward Blair;Charles Redwood;Houman Ashrafian;Marisa Oliveira

  713
  Citations

• Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway.

  Houman Ashrafian;Gabor Czibik;Mohamed Bellahcene;Dunja Aksentijević

  292
  Citations

• The molecular anatomy of caldesmon.

  S B Marston;C S Redwood

  287
  Citations

• Dilated and Hypertrophic Cardiomyopathy Mutations in Troponin and α-Tropomyosin Have Opposing Effects on the Calcium Affinity of Cardiac Thin Filaments

  Paul Robinson;Peter J. Griffiths;Hugh Watkins;Charles S. Redwood

  287
  Citations

• Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy

  Charles S. Redwood;Johanna C. Moolman-Smook;Johanna C. Moolman-Smook;Hugh Watkins

  258
  Citations

• Physiological regulation of eukaryotic topoisomerase II.

  Richard J Isaacs;Sally L Davies;M.Ines Sandri;Charles Redwood

  255
  Citations

• Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy

  Christopher N. Toepfer;Christopher N. Toepfer;Amanda C. Garfinkel;Gabriela Venturini;Gabriela Venturini;Hiroko Wakimoto

  232
  Citations

• Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy.

  Kathryn Elliott;Hugh Watkins;Charles S. Redwood

  208
  Citations

• Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.

  Mahmooda Mirza;Steven Marston;Ruth Willott;Christopher Ashley

  206
  Citations

• A Mutant Tropomyosin That Causes Hypertrophic Cardiomyopathy Is Expressed In Vivo and Associated With an Increased Calcium Sensitivity

  R. Bottinelli;D. A. Coviello;C. S. Redwood;M. A. Pellegrino

  204
  Citations

• Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.

  Paul Robinson;Mahmooda Mirza;Adam Knott;Hassan Abdulrazzak

  189
  Citations

• Mutations in the gamma2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.

  Edward Blair;Charles Redwood;Houman Ashrafian;Marisa Oliveira

  183
  Citations

• Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.

  Christopher N. Toepfer;Christopher N. Toepfer;Hiroko Wakimoto;Hiroko Wakimoto;Amanda C. Garfinkel;Barbara McDonough

  170
  Citations

• Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric Dilated Cardiomyopathy

  Neal K. Lakdawala;Lisa Dellefave;Charles S. Redwood;Elizabeth Sparks

  159
  Citations

• Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.

  Paul Robinson;Simon Lipscomb;Laura C. Preston;Elissa Altin

  147
  Citations

• Mutations of the light meromyosin domain of the beta-myosin heavy chain rod in hypertrophic cardiomyopathy.

  Edward Blair;Charles Redwood;Marisa de Jesus Oliveira;J.C. Moolman-Smook

  130
  Citations

• The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon.

  S.B. Marston;C.S. Redwood

  127
  Citations

• Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.

  Wu Bing;Charles S. Redwood;Charles S. Redwood;Ian F. Purcell;Ian F. Purcell;Giovanna Esposito;Giovanna Esposito

  113
  Citations

• Alpha-tropomyosin mutations in inherited cardiomyopathies

  Charles Redwood;Paul Robinson

  112
  Citations

• Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy

  Sebastian Carballo;Paul Robinson;Robyn Otway;Diane Fatkin

  109
  Citations