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Biology and Biochemistry

D-Index
67
Citations
11821
World Ranking
8405
National Ranking
3783

Overview

Steven B. Marston is affiliated with the National Institutes of Health in the United States, contributing extensively to research in medicine and molecular biology. Their work primarily focuses on cardiology and cardiovascular medicine, with substantial contributions in related subfields such as molecular biology, cellular and molecular neuroscience, spectroscopy, and surgery.

The scientist's research covers a diverse range of topics, including:

  • Cardiomyopathy and myosin studies
  • Cardiovascular effects of exercise
  • RNA and protein synthesis mechanisms
  • Viral infections and immunology research
  • Genetic neurodegenerative diseases
  • RNA research and splicing
  • Ion channel regulation and function

Steven B. Marston has published in various prominent venues. Frequent publication outlets include:

  • Frontiers in Physiology
  • Journal of Muscle Research and Cell Motility
  • Proceedings of the National Academy of Sciences
  • International Journal of Molecular Sciences
  • Cardiovascular Research

Recent notable papers authored or co-authored by Marston are:

  • "Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics" (2020), Proceedings of the National Academy of Sciences
  • "Small Molecules Acting on Myofilaments as Treatments for Heart and Skeletal Muscle Diseases" (2020), International Journal of Molecular Sciences
  • "Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation" (2020), Cardiovascular Research
  • "Approaches to High-Throughput Analysis of Cardiomyocyte Contractility" (2020), Frontiers in Physiology
  • "Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation" (2022), Archives of Biochemistry and Biophysics

The scientist collaborates regularly with several co-authors, including:

  • Zeyu Yang
  • Ian R. Gould
  • Andrew E. Messer
  • Alice Sheehan
  • Charles Redwood

The corpus of their work prominently reflects an emphasis on cardiomyopathy-related mechanisms and cardiovascular function, combining experimental, computational, and molecular approaches to understand muscle diseases and cardiac contractility.

Best Publications

  • The molecular anatomy of caldesmon.

    S B Marston;C S Redwood

  • Troponin phosphorylation and regulatory function in human heart muscle: Dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure

    Andrew E. Messer;Adam M. Jacques;Steven B. Marston

  • Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.

    Mahmooda Mirza;Steven Marston;Ruth Willott;Christopher Ashley

  • Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.

    Paul Robinson;Mahmooda Mirza;Adam Knott;Hassan Abdulrazzak

  • Caldesmon is a Ca2+-regulatory component of native smooth-muscle thin filaments.

    S B Marston;W Lehman

  • Alpha-cardiac actin mutations produce atrial septal defects

    Hans Matsson;Jacqueline Eason;Carol S. Bookwalter;Joakim Klar

  • Atomic model of the human cardiac muscle myosin filament

    Hind A. AL-Khayat;Robert W. Kensler;John M. Squire;Steven B. Marston

  • Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle.

    O'Neal Copeland;Sakthivel Sadayappan;Andrew E. Messer;Ger J.M. Steinen

  • How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies

    Steven B. Marston

  • Some Properties of Human Small Heat Shock Protein Hsp20 (HspB6)

    Olesya V. Bukach;Alim S. Seit-Nebi;Steven B. Marston;Nikolai B. Gusev

  • In Vitro Motility Analysis of Actin-Tropomyosin Regulation by Troponin and Calcium THE THIN FILAMENT IS SWITCHED AS A SINGLE COOPERATIVE UNIT

    Iain D. C. Fraser;Steven B. Marston

  • Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle

    Adam M. Jacques;O'Neal Copeland;Andrew E. Messer;Clare E. Gallon

  • Purification and properties of Ca2+-regulated thin filaments and F-actin from sheep aorta smooth muscle

    Steven B. Marston;Christopher W. J. Smith

  • Calcium ion-regulated thin filaments from vascular smooth muscle

    S B Marston;R M Trevett;M Walters

  • The dissociation constant of the actin-heavy meromyosin subfragment-1 complex.

    Steven Marston;Annemarie Weber

  • The essential role of tropomyosin in cooperative regulation of smooth muscle thin filament activity by caldesmon.

    S.B. Marston;C.S. Redwood

  • Genotype-phenotype correlations in ACTA1 mutations that cause congenital myopathies.

    Juan-Juan Feng;Steven Marston

  • Modulation of Thin Filament Activation by Breakdown or Isoform Switching of Thin Filament Proteins: Physiological and Pathological Implications

    Steven B. Marston;Charles S. Redwood

  • Mutation Update and Genotype-Phenotype Correlations of Novel and Previously Described Mutations in TPM2 and TPM3 Causing Congenital Myopathies

    Minttu Marttila;Vilma-Lotta Lehtokari;Steven Marston;Tuula A. Nyman

  • Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.

    Wu Bing;Charles S. Redwood;Charles S. Redwood;Ian F. Purcell;Ian F. Purcell;Giovanna Esposito;Giovanna Esposito

Frequent Co-Authors

Cristobal G. dos Remedios
Cristobal G. dos Remedios Victor Chang Cardiac Research Institute
Charles Redwood
Charles Redwood University of Oxford
Hugh Watkins
Hugh Watkins University of Oxford
William J. McKenna
William J. McKenna University College London
Iain D. C. Fraser
Iain D. C. Fraser National Institutes of Health
Nigel G. Laing
Nigel G. Laing University of Western Australia
Dominic J. Wells
Dominic J. Wells Royal Veterinary College
William Lehman
William Lehman Boston University
Kieran Clarke
Kieran Clarke University of Oxford
Alexander R. Lyon
Alexander R. Lyon Imperial College London

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