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Biology and Biochemistry

D-Index
62
Citations
10598
World Ranking
11035
National Ranking
4768

Overview

Pieter P. de Tombe is affiliated with the University of Illinois at Chicago in the United States. Their primary research field is Medicine, with a focus on Cardiology and Cardiovascular Medicine. Additional areas of study include Biomedical Engineering, Molecular Biology, Surgery, and Biomaterials. The scientist's work covers diverse topics within cardiac research, including Cardiomyopathy and Myosin Studies, Cardiovascular Effects of Exercise, Cardiac Electrophysiology and Arrhythmias, Cardiovascular Function and Risk Factors, Tissue Engineering and Regenerative Medicine, Electrospun Nanofibers in Biomedical Applications, and Ion Channel Regulation and Function.

De Tombe has published extensively in several notable journals. Frequent publication venues include:

  • Journal of Molecular and Cellular Cardiology
  • Biophysical Journal
  • Cardiovascular Research
  • The Journal of General Physiology
  • Journal of Muscle Research and Cell Motility

Among their recent papers are:

  • Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro, 2021, Cardiovascular Research
  • Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation, 2020, Cardiovascular Research
  • Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility, 2021, Journal of Molecular and Cellular Cardiology
  • Intact myocardial preparations reveal intrinsic transmural heterogeneity in cardiac mechanics, 2020, Journal of Molecular and Cellular Cardiology
  • Cryo-electron tomography of intact cardiac muscle reveals myosin binding protein-C linking myosin and actin filaments, 2023, Journal of Muscle Research and Cell Motility

Frequent co-authors collaborating with Pieter P. de Tombe include:

  • Olivier Cazorla
  • Oleg Lookin
  • Fotios G. Pitoulis
  • Cesare M. Terracciano
  • R. John Solaro

Best Publications

  • Functional Consequences of Caspase Activation in Cardiac Myocytes

    Catherine Communal;Marius Sumandea;Pieter de Tombe;Jagat Narula

  • Titin Isoform Switch in Ischemic Human Heart Disease

    Ciprian Neagoe;Michael Kulke;Federica del Monte;Judith K. Gwathmey

  • Approximate Model of Cooperative Activation and Crossbridge Cycling in Cardiac Muscle Using Ordinary Differential Equations

    John Jeremy Rice;Fei Wang;Donald M. Bers;Pieter P. de Tombe

  • Myofilament length dependent activation.

    Pieter P. de Tombe;Ryan D. Mateja;Kittipong Tachampa;Younss Ait Mou

  • Identification of a Functionally Critical Protein Kinase C Phosphorylation Residue of Cardiac Troponin T

    Marius P. Sumandea;W.Glen Pyle;Tomoyoshi Kobayashi;Pieter P. de Tombe

  • Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardium

    Thomas C. Irving;John Konhilas;Darold Perry;Robert Fischetti

  • Augmented Protein Kinase C-α–Induced Myofilament Protein Phosphorylation Contributes to Myofilament Dysfunction in Experimental Congestive Heart Failure

    Rashad J. Belin;Marius P. Sumandea;Edward J. Allen;Kelly Schoenfelt

  • Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

    Younss Ait-Mou;Karen Hsu;Karen Hsu;Gerrie P. Farman;Mohit Kumar

  • Troponin I in the murine myocardium: influence on length‐dependent activation and interfilament spacing

    John P. Konhilas;Thomas C. Irving;Beata M. Wolska;Eias E. Jweied

  • Myofilament Calcium Sensitivity in Skinned Rat Cardiac Trabeculae Role of Interfilament Spacing

    John P. Konhilas;Thomas C. Irving;Pieter P. de Tombe

  • Cooperative activation in cardiac muscle: impact of sarcomere length.

    David P. Dobesh;John P. Konhilas;Pieter P. de Tombe

  • Protein Kinase A Does Not Alter Economy of Force Maintenance in Skinned Rat Cardiac Trabeculae

    Pieter P. de Tombe;G.J.M. Stienen

  • Intracellular Localization and Functional Effects of P21-Activated Kinase-1 (Pak1) in Cardiac Myocytes

    Yunbo Ke;Lynn Wang;W. Glen Pyle;Pieter P. de Tombe

  • Impact of β-myosin heavy chain isoform expression on cross-bridge cycling kinetics

    Veronica L. M. Rundell;Vlasios Manaves;Anne F. Martin;Pieter P. de Tombe

  • The Troponin C G159D Mutation Blunts Myofilament Desensitization Induced by Troponin I Ser23/24 Phosphorylation

    Brandon J. Biesiadecki;Tomoyoshi Kobayashi;John S. Walker;R. John Solaro

  • Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation.

    John P. Konhilas;Thomas C. Irving;Pieter P. de Tombe

  • Cardiac myofilaments: mechanics and regulation.

    Pieter P de Tombe

  • Blebbistatin: use as inhibitor of muscle contraction

    Gerrie P. Farman;Kittipong Tachampa;Ryan Mateja;Olivier Cazorla;Olivier Cazorla

  • Length-dependent activation in three striated muscle types of the rat.

    John P. Konhilas;Thomas C. Irving;Pieter P. de Tombe

  • Ca2+ activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T

    Murali Chandra;Veronica L. M. Rundell;Jil C. Tardiff;Leslie A. Leinwand

Frequent Co-Authors

R. John Solaro
R. John Solaro University of Illinois at Chicago
David A. Kass
David A. Kass Johns Hopkins University School of Medicine
Alain Lacampagne
Alain Lacampagne University of Montpellier
Marion L. Greaser
Marion L. Greaser University of Wisconsin–Madison
Peter H. Backx
Peter H. Backx York University
Kenneth B. Margulies
Kenneth B. Margulies University of Pennsylvania
Roger Craig
Roger Craig University of Massachusetts Chan Medical School
Jennifer E. Van Eyk
Jennifer E. Van Eyk Cedars-Sinai Medical Center
Christine E. Seidman
Christine E. Seidman Harvard University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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