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Peter H. Backx

Peter H. Backx

D-Index & Metrics

Medicine

D-Index
84
Citations
26892
World Ranking
15053
National Ranking
623

Research.com Recognitions

  • 2008 - Fellow of the Royal Society of Canada Academy of Science

Overview

Peter H. Backx is affiliated with York University in Canada and has made contributions primarily in the field of Medicine, with a specific focus on Cardiology and Cardiovascular Medicine. Their work spans several subfields including Molecular Biology, Physiology, Surgery, and Cellular and Molecular Neuroscience.

The researcher has a significant number of publications covering various topics related to cardiovascular health and function. Key research topics include:

  • Cardiovascular Effects of Exercise
  • Cardiac electrophysiology and arrhythmias
  • Cardiac Fibrosis and Remodeling
  • Cardiomyopathy and Myosin Studies
  • Cardiovascular Function and Risk Factors
  • Atrial Fibrillation Management and Outcomes
  • Adipose Tissue and Metabolism

Frequent coauthors who have collaborated extensively with Backx include Robert Lakin, Nazari Polidovitch, Milica Radisic, Jian Wu, and Anthony O. Gramolini.

Published research appears regularly in several leading scientific journals. Frequent publication venues are:

  • Journal of Molecular and Cellular Cardiology
  • Frontiers in Physiology
  • Circulation Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Cardiovascular Medicine

Selected recent papers by Peter H. Backx include:

  • "Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways," 2024, Nature Cardiovascular Research
  • "Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3," 2023, Proceedings of the National Academy of Sciences
  • "Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts," 2022, Nature Communications
  • "Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α," 2020, Journal of Clinical Investigation
  • "Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties," 2020, Frontiers in Physiology

Peter H. Backx has been recognized as a Fellow of the Royal Society of Canada in 2008 under the Academy of Science category.

Best Publications

  • Angiotensin-converting enzyme 2 is an essential regulator of heart function

    Michael A. Crackower;Renu Sarao;Renu Sarao;Gavin Y. Oudit;Gavin Y. Oudit;Chana Yagil

  • VEGF inhibition and renal thrombotic microangiopathy.

    Vera Eremina;J. Ashley Jefferson;Jolanta Kowalewska;Howard Hochster

  • Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes

    Sara S Nunes;Jason W Miklas;Jie Liu;Roozbeh Aschar-Sobbi

  • Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

    Michael A. Crackower;Gavin Y. Oudit;Ivona Kozieradzki;Ivona Kozieradzki;Renu Sarao;Renu Sarao

  • The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease.

    Gavin Y Oudit;Hui Sun;Benoit-Gilles Kerfant;Michael A Crackower

  • A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.

    Yimu Zhao;Naimeh Rafatian;Nicole T. Feric;Brian J. Cox

  • L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy.

    Gavin Y Oudit;Hui Sun;Maria G Trivieri;Sheryl E Koch

  • GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure

    Minsuk Kim;Mathew J Platt;Tadao Shibasaki;Susan E Quaggin

  • Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters

    Tami A. Martino;Gavin Y. Oudit;Andrew M. Herzenberg;Nazneen Tata

  • Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations

    Jee Hoon Lee;Stephanie I. Protze;Zachary Laksman;Peter H. Backx

  • The role of ACE2 in cardiovascular physiology.

    Gavin Y. Oudit;Michael A. Crackower;Peter H. Backx;Josef M. Penninger

  • Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.

    Fina Lovren;Yi Pan;Adrian Quan;Hwee Teoh

  • A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair.

    Yan Zeng;William W Du;William W Du;Yingya Wu;Yingya Wu;Zhenguo Yang;Zhenguo Yang

  • Molecular localization of an ion-binding site within the pore of mammalian sodium channels.

    Peter H. Backx;David T. Yue;John H. Lawrence;Eduardo Marban

  • Relationship between intracellular calcium and contractile force in stunned myocardium. Direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle.

    Wei Dong Gao;Dan Atar;Peter H. Backx;Eduardo Marban

  • Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker

    Stephanie I Protze;Jie Liu;Udi Nussinovitch;Lily Ohana;Lily Ohana

  • Loss of Angiotensin-Converting Enzyme-2 (Ace2) Accelerates Diabetic Kidney Injury

    Denise W. Wong;Gavin Y. Oudit;Heather Reich;Zamaneh Kassiri

  • Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels

    Dan Atar;Peter H. Backx;Melissa M. Appel;Wei Dong Gao

  • Regulation of cardiac excitation–contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito)

    Rajan Sah;Rafael J. Ramirez;Gavin Y. Oudit;Dominica Gidrewicz

  • The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.

    Danny L. Costantini;Eric P. Arruda;Pooja Agarwal;Kyoung-Han Kim

Frequent Co-Authors

Gavin Y. Oudit
Gavin Y. Oudit University of Alberta
Josef M. Penninger
Josef M. Penninger University of British Columbia
Anthony O. Gramolini
Anthony O. Gramolini University of Toronto
Eduardo Marbán
Eduardo Marbán Cedars-Sinai Medical Center
David H. MacLennan
David H. MacLennan University of Toronto
Gordon Keller
Gordon Keller University of Toronto
Paul Dorian
Paul Dorian University of Toronto
Benoit G. Bruneau
Benoit G. Bruneau Gladstone Institutes
Milica Radisic
Milica Radisic University of Toronto
John S. Floras
John S. Floras University Health Network

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