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D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
7238
World Ranking
17355
National Ranking
1361

Research.com Recognitions

  • 2003 - Fellow of the Royal Society, United Kingdom

Overview

Malcolm Irving is affiliated with King's College London in the United Kingdom. Their research primarily focuses on the intersecting fields of Medicine and Biochemistry, Genetics and Molecular Biology. The scientist's work prominently addresses areas within Cardiology and Cardiovascular Medicine, Molecular Biology, and Biomedical Engineering, with additional contributions in Neurology and Astronomy and Astrophysics.

The main topics covered in Malcolm Irving's research include Cardiomyopathy and Myosin Studies, Cardiovascular Effects of Exercise, Muscle Physiology and Disorders, Cardiovascular Function and Risk Factors, Muscle Activation and Electromyography Studies, Ion Channel Regulation and Function, and Viral Infections and Immunology Research.

Some of the recent papers authored or co-authored by Malcolm Irving are:

  • Myosin filament-based regulation of the dynamics of contraction in heart muscle (2020, Proceedings of the National Academy of Sciences)
  • Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing (2021, Proceedings of the National Academy of Sciences)
  • Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing (2021, The Journal of General Physiology)
  • Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle (2021, eLife)
  • Cardiac myosin regulatory light chain kinase modulates cardiac contractility by phosphorylating both myosin regulatory light chain and troponin I (2020, Journal of Biological Chemistry)

Frequent co-authors collaborating with Malcolm Irving include:

  • Elisabetta Brunello
  • Luca Fusi
  • Theyencheri Narayanan
  • So-Jin Park-Holohan
  • Jesús G. Ovejero

The scientist regularly publishes in venues such as:

  • Biophysical Journal
  • Proceedings of the National Academy of Sciences
  • The Journal of General Physiology
  • Journal of Biological Chemistry
  • The Journal of Physiology

Malcolm Irving has been recognized with the award of Fellow of the Royal Society, United Kingdom, in 2003.

Best Publications

  • Skeletal Muscle Performance Determined by Modulation of Number of Myosin Motors Rather Than Motor Force or Stroke Size

    Gabriella Piazzesi;Massimo Reconditi;Marco Linari;Leonardo Lucii

  • Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

    Marco Linari;Elisabetta Brunello;Elisabetta Brunello;Massimo Reconditi;Luca Fusi

  • Myosin head movements are synchronous with the elementary force-generating process in muscle.

    Malcolm Irving;Vincenzo Lombardi;Gabriella P. Piazzesi;Michael A. Ferenczi

  • Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction

    J. E. T. Corrie;B. D. Brandmeier;R. E. Ferguson;D. R. Trentham

  • Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle

    M. Irving;T. St Claire Allen;C. Sabido-David;J. S. Craik

  • The myosin motor in muscle generates a smaller and slower working stroke at higher load

    Massimo Reconditi;Marco Linari;Leonardo Lucii;Alex Stewart

  • The Stiffness of Skeletal Muscle in Isometric Contraction and Rigor: The Fraction of Myosin Heads Bound to Actin

    Marco Linari;Ian Dobbie;Massimo Reconditi;Natalia Koubassova

  • Elastic bending and active tilting of myosin heads during muscle contraction

    Ian Dobbie;Marco Linari;Gabriella Piazzesi;Massimo Reconditi

  • Mechanism of force generation by myosin heads in skeletal muscle

    Gabriella Piazzesi;Massimo Reconditi;Marco Linari;Leonardo Lucii

  • Regulation of Contraction by the Thick Filaments in Skeletal Muscle

    Malcolm Irving

  • Elastic distortion of myosin heads and repriming of the working stroke in muscle.

    Vincenzo Lombard;Gabriella Piazzesi;Michael A. Ferenczi;Hilary Thirlwell

  • Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin

    Elisabetta Brunello;Massimo Reconditi;Ravikrishnan Elangovan;Marco Linari

  • Interference fine structure and sarcomere length dependence of the axial x-ray pattern from active single muscle fibers

    M. Linari;G. Piazzesi;I. Dobbie;N. Koubassova

  • Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

    Thomas Kampourakis;Ziqian Yan;Mathias Gautel;Yin-Biao Sun

  • Conformation of the myosin motor during force generation in skeletal muscle.

    Malcolm Irving;Gabriella Piazzesi;Leonardo Lucii;Yin-Biao Sun

  • Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

    Thomas Kampourakis;Yin-Biao Sun;Malcolm Irving

  • Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

    L. Fusi;E. Brunello;Z. Yan;M. Irving

  • Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle.

    Yin-Biao Sun;Fang Lou;Malcolm Irving

  • Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.

    Thomas Kampourakis;Xuemeng Zhang;Yin Biao Sun;Malcolm Irving

  • Myosin filament-based regulation of the dynamics of contraction in heart muscle.

    Elisabetta Brunello;Luca Fusi;Andrea Ghisleni;So-Jin Park-Holohan

Frequent Co-Authors

Theyencheri Narayanan
Theyencheri Narayanan European Synchrotron Radiation Facility
David R. Trentham
David R. Trentham King's College London
John E. T. Corrie
John E. T. Corrie Medical Research Council
John Kendrick-Jones
John Kendrick-Jones MRC Laboratory of Molecular Biology
Tony Ng
Tony Ng King's College London
Yale E. Goldman
Yale E. Goldman University of Pennsylvania
Brian D. Sykes
Brian D. Sykes University of Alberta
Mathias Gautel
Mathias Gautel King's College London
Olivier Diat
Olivier Diat Institut de Chimie
Maddy Parsons
Maddy Parsons King's College London

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