2026 James A. Spudich: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	114	824	731	516	449	394	54556

Research.com Recognitions

1997 - Fellow of the American Academy of Arts and Sciences
1991 - Member of the National Academy of Sciences

Overview

James A. Spudich is affiliated with Stanford University in the United States. Their research primarily focuses on medicine as well as biochemistry, genetics, and molecular biology. More specifically, their work is centered on cardiology and cardiovascular medicine, molecular biology, genetics, cell biology, and epidemiology.

The main topics covered in Spudich's research include:

Cardiomyopathy and Myosin Studies
Cardiovascular Effects of Exercise
Muscle Physiology and Disorders
Cardiovascular Function and Risk Factors
Cellular Mechanics and Interactions
Trypanosoma species research and implications
Viral Infections and Immunology Research

Spudich has published extensively, contributing to several scientific journals and venues. Frequent publication venues include:

Biophysical Journal
bioRxiv (Cold Spring Harbor Laboratory)
Proceedings of the National Academy of Sciences
Frontiers in Physiology
Science Advances

Frequent co-authors collaborating with Spudich are:

Kathleen M. Ruppel
Neha Nandwani
Aminah Dawood
Divya Pathak
Daniel Bernstein

Among notable recent papers authored or co-authored by Spudich are:

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin, 2020, Science Advances
The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches, 2020, Annual Review of Biochemistry
Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state, 2021, Proceedings of the National Academy of Sciences
Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients, 2023, Science Advances
Cryo-EM structure of the folded-back state of human β-cardiac myosin, 2023, Nature Communications

Spudich has been recognized with several awards, including:

Fellow of the American Academy of Arts and Sciences, 1997
Member of the National Academy of Sciences, 1991

Best Publications

The Regulation of Rabbit Skeletal Muscle Contraction I. BIOCHEMICAL STUDIES OF THE INTERACTION OF THE TROPOMYOSIN-TROPONIN COMPLEX WITH ACTIN AND THE PROTEOLYTIC FRAGMENTS OF MYOSIN

James A. Spudich;Susan Watt

6990
Citations
Single myosin molecule mechanics: piconewton forces and nanometre steps

Jeffrey T. Finer;Robert M. Simmons;James A. Spudich

2411
Citations
Purification of muscle actin.

Joel D. Pardee;James A. Spudich

2409
Citations
Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination

Arturo De Lozanne;James A. Spudich

1220
Citations
Fluorescent actin filaments move on myosin fixed to a glass surface

Stephen J. Kron;James A. Spudich

1111
Citations
Optimized localization analysis for single-molecule tracking and super-resolution microscopy.

Kim I Mortensen;L Stirling Churchman;James A Spudich;Henrik Flyvbjerg

986
Citations
Myosin-V is a processive actin-based motor

Amit D. Mehta;Ronald S. Rock;Matthias Rief;James A. Spudich

984
Citations
Single-Molecule Biomechanics with Optical Methods

Amit D. Mehta;Matthias Rief;James A. Spudich;David A. Smith

927
Citations
Quantitative measurements of force and displacement using an optical trap.

Robert M. Simmons;Jeffrey T. Finer;Steven Chu;James A. Spudich

712
Citations
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination.

Margaret Clarke;James A. Spudich

652
Citations
Myosin structure and function in cell motility.

Hans M. Warrick;James A. Spudich

651
Citations
Myosin subfragment-1 is sufficient to move actin filaments in vitro.

Yoko Yano Toyoshima;Stephen J. Kron;Elizabeth M. McNally;Kenneth R. Niebling

651
Citations
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Eric M. Green;Hiroko Wakimoto;Robert L. Anderson;Marc J. Evanchik

631
Citations
Movement of myosin-coated fluorescent beads on actin cables in vitro.

Michael P. Sheetz;James A. Spudich

598
Citations
How molecular motors work

James A. Spudich

584
Citations
The neck region of the myosin motor domain acts as a lever arm to generate movement

Taro Q. P. Uyeda;Paul D. Abramson;James A. Spudich

568
Citations
Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin.

Taro Q.P. Uyeda;Stephen J. Kron;James A. Spudich

558
Citations
Myosin VI is a processive motor with a large step size.

Ronald S. Rock;Sarah E. Rice;Amber L. Wells;Thomas J. Purcell

548
Citations
Assays for actin sliding movement over myosin-coated surfaces.

Stephen J. Kron;Yoko Y. Toyoshima;Taro Q.P. Uyeda;James A. Spudich

507
Citations
Myosin-V stepping kinetics: A molecular model for processivity

Matthias Rief;Ronald S. Rock;Amit D. Mehta;Mark S. Mooseker

500
Citations