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Biology and Biochemistry

D-Index
86
Citations
26156
World Ranking
2969
National Ranking
1519

Overview

James R. Sellers is affiliated with the National Institutes of Health in the United States. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, with a primary focus on molecular biology, cardiology and cardiovascular medicine, and cell biology. They also contribute to fields related to atomic and molecular physics and optics, as well as sensory systems.

The scientist's work covers key topics such as cardiomyopathy and myosin studies, cellular mechanics and interactions, muscle physiology and disorders, force microscopy techniques and applications, microtubule and mitosis dynamics, RNA research and splicing, and hearing, cochlea, tinnitus, and genetics.

James R. Sellers has collaborated frequently with several coauthors, including Neil Billington, Yasuharu Takagi, Rong Liu, Sarah M. Heissler, and Charles Bond. These collaborations have contributed to a substantial number of publications, especially in well-regarded journals and publication venues.

Their publication record shows a high level of activity in certain venues, with multiple publications in bioRxiv (Cold Spring Harbor Laboratory), the Biophysical Journal, the Journal of Biological Chemistry, Nature Communications, and The Journal of Cell Biology.

Recent notable publications include:

  • "The formin inhibitor SMIFH2 inhibits members of the myosin superfamily," 2021, Journal of Cell Science
  • "Competition between kinesin-1 and myosin-V defines Drosophila posterior determination," 2020, eLife
  • "Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease," 2020, Blood
  • "Myosin-5 varies its step length to carry cargo straight along the irregular F-actin track," 2024, Proceedings of the National Academy of Sciences
  • "Cryo-EM structure of the autoinhibited state of myosin-2," 2021, Science Advances

Best Publications

  • Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor

    Aaron F. Straight;Amy Cheung;John Limouze;Irene Chen

  • Mechanism of Blebbistatin Inhibition of Myosin II

    Mihály Kovács;Judit Tóth;Judit Tóth;Csaba Hetényi;András Málnási-Csizmadia

  • Myosins: a diverse superfamily.

    James R Sellers

  • Quantitative mass imaging of single biological macromolecules

    Gavin Young;Nikolas Hundt;Daniel Cole;Adam Fineberg

  • Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

    Karl Poetter;He Jiang;Shahin Hassanzadeh;Stephen R. Master

  • Identification of an organelle receptor for myosin-Va

    Xufeng S. Wu;Kang Rao;Hong Zhang;Fei Wang

  • Specificity of blebbistatin, an inhibitor of myosin II.

    John Limouze;Aaron F Straight;Timothy J Mitchison;James R Sellers

  • The gated gait of the processive molecular motor, myosin V.

    Claudia Veigel;Fei Wang;Marc L. Bartoo;James R. Sellers

  • Caldesmon, a novel regulatory protein in smooth muscle and nonmuscle actomyosin systems.

    K Sobue;J R Sellers

  • Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.

    Inna A. Belyantseva;Erich T. Boger;Erich T. Boger;Sadaf Naz;Gregory I. Frolenkov

  • Identification and Characterization of Nonmuscle Myosin II-C, a New Member of the Myosin II Family

    Eliahu Golomb;Eliahu Golomb;Xuefei Ma;Siddhartha S. Jana;Yvette A. Preston

  • Two-headed binding of a processive myosin to F-actin

    Matthew L. Walker;Stan A. Burgess;James R. Sellers;Fei Wang

  • Walking to work: roles for class V myosins as cargo transporters

    John A. Hammer;James R. Sellers

  • Protein kinase C modulates in vitro phosphorylation of the smooth muscle heavy meromyosin by myosin light chain kinase.

    M Nishikawa;J R Sellers;R S Adelstein;H Hidaka

  • Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.

    G. Cuda;Lameh Fananapazir;Wen-Si Zhu;J. R. Sellers

  • Load-dependent kinetics of myosin-V can explain its high processivity

    Claudia Veigel;Stephan Schmitz;Fei Wang;James R Sellers

  • Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform.

    Mihály Kovács;Fei Wang;Aihua Hu;Yue Zhang

  • Kinetic Mechanism of Non-Muscle Myosin IIB: Functional Adaptations for Tension Generation and Maintenance

    Fei Wang;Mihály Kovács;Aihua Hu;John Limouze

  • Reversible phosphorylation of smooth muscle myosin, heavy meromyosin, and platelet myosin.

    J R Sellers;M D Pato;R S Adelstein

  • Factors affecting movement of F-actin filaments propelled by skeletal muscle heavy meromyosin.

    E. Homsher;Fei Wang;J. R. Sellers

Frequent Co-Authors

Robert S. Adelstein
Robert S. Adelstein National Institutes of Health
John A. Hammer
John A. Hammer National Institutes of Health
Thomas B. Friedman
Thomas B. Friedman National Institutes of Health
Philipp Kukura
Philipp Kukura University of Oxford
Edward D. Korn
Edward D. Korn National Institutes of Health
John Kendrick-Jones
John Kendrick-Jones MRC Laboratory of Molecular Biology
Alexander D. Bershadsky
Alexander D. Bershadsky National University of Singapore
Walter F. Stafford
Walter F. Stafford Harvard University
Vladimir I. Gelfand
Vladimir I. Gelfand Northwestern University
Inna A. Belyantseva
Inna A. Belyantseva National Institutes of Health

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