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D-Index & Metrics

Biology and Biochemistry

D-Index
98
Citations
51898
World Ranking
1625
National Ranking
906

Overview

H. Lee Sweeney is affiliated with the University of Florida in the United States. Their research spans biochemistry, genetics, molecular biology, and medicine, with a primary focus on molecular biology and cardiology-related fields.

Their work covers multiple subfields such as molecular biology, cardiology and cardiovascular medicine, genetics, cell biology, and cellular and molecular neuroscience. The primary topics of research include muscle physiology and disorders, cardiomyopathy and myosin studies, cellular mechanics and interactions, muscle activation and electromyography studies, virus-based gene therapy research, genetic neurodegenerative diseases, and exercise and physiological responses.

Recent publications by H. Lee Sweeney include:

  • The D2.mdx mouse as a preclinical model of the skeletal muscle pathology associated with Duchenne muscular dystrophy, 2020, Scientific Reports
  • MR biomarkers predict clinical function in Duchenne muscular dystrophy, 2020, Neurology
  • Modeling disease trajectory in Duchenne muscular dystrophy, 2020, Neurology
  • High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism, 2021, eLife
  • Myosin Structures, 2020, Advances in experimental medicine and biology

H. Lee Sweeney has collaborated frequently with a group of coauthors including David W. Hammers, Young Il Lee, Cora C. Hart, Glenn A. Walter, and Anne Houdusse. These collaborations reflect a network of research often centered around muscle physiology, molecular mechanisms, and disease models.

Their publications appear across a range of journals and venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurology
  • Journal of Clinical Investigation
  • eLife
  • Journal of Neuromuscular Diseases

Best Publications

  • Matrix elasticity directs stem cell lineage specification.

    Adam J. Engler;Shamik Sen;H. Lee Sweeney;Dennis E. Discher

  • Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments

    Adam J. Engler;Maureen A. Griffin;Shamik Sen;Carsten G. Bönnemann

  • PTC124 targets genetic disorders caused by nonsense mutations

    Ellen M. Welch;Elisabeth R. Barton;Jin Zhuo;Yuki Tomizawa

  • Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

    Antonio Musarò;Karl McCullagh;Angelika Paul;Leslie Houghton

  • Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function

    Elisabeth R. Barton-Davis;Daria I. Shoturma;Antonio Musaro;Nadia Rosenthal

  • Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function

    H. L. Sweeney;B. F. Bowman;J. T. Stull

  • Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance

    Mark F. Berry;Adam J. Engler;Y. Joseph Woo;Timothy J. Pirolli

  • Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice

    Elisabeth R. Barton-Davis;Laurence Cordier;Daria I. Shoturma;Stuart E. Leland

  • Myosin VI is an actin-based motor that moves backwards

    Wells Al;Lin Aw;Chen Lq;Safer D

  • A simple analysis of the "phosphocreatine shuttle"

    R. A. Meyer;H. L. Sweeney;M. J. Kushmerick

  • The kinetic mechanism of myosin V.

    Enrique M. De La Cruz;Amber L. Wells;Steven S. Rosenfeld;E. Michael Ostap

  • Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice.

    Elisabeth R. Barton;Linda Morris;Antonio Musaro;Nadia Rosenthal

  • Myosin VI is a processive motor with a large step size.

    Ronald S. Rock;Sarah E. Rice;Amber L. Wells;Thomas J. Purcell

  • Ataluren treatment of patients with nonsense mutation dystrophinopathy

    Katharine Bushby;Richard Finkel;Brenda Wong;Richard Barohn

  • Structural and functional insights into the Myosin motor mechanism

    H. Lee Sweeney;Anne Houdusse

  • Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

    Craig M McDonald;Craig Campbell;Ricardo Erazo Torricelli;Richard S Finkel;Richard S Finkel

  • Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

    Douglas P Millay;Michelle A Sargent;Hanna Osinska;Christopher P Baines

  • Alteration of cross-bridge kinetics by myosin light chain phosphorylation in rabbit skeletal muscle: implications for regulation of actin-myosin interaction.

    H. Lee Sweeney;James T. Stull

  • A structural state of the myosin V motor without bound nucleotide

    Pierre Damien Coureux;Amber L. Wells;Julie Ménétrey;Christopher M. Yengo

  • Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

    Lawrence T Bish;Kevin J Morine;Margaret M Sleeper;Julio Sanmiguel

Frequent Co-Authors

Anne Houdusse
Anne Houdusse Université Paris Cité
Richard S. Finkel
Richard S. Finkel St. Jude Children's Research Hospital
Dennis E. Discher
Dennis E. Discher University of Pennsylvania
Craig M. McDonald
Craig M. McDonald University of California, Davis
James T. Stull
James T. Stull The University of Texas Southwestern Medical Center
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Barry J. Byrne
Barry J. Byrne University of Florida
James M. Wilson
James M. Wilson University of Pennsylvania
Kathleen M. Trybus
Kathleen M. Trybus University of Vermont

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