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Biology and Biochemistry

D-Index
110
Citations
86715
World Ranking
955
National Ranking
593

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2012 - Member of the National Academy of Engineering For elucidation of the effects of mechanical forces on cell physiology and stem cell development.

Overview

Dennis E. Discher is affiliated with the University of Pennsylvania in the United States. Their research spans multiple fields primarily within biology, focusing on the intersection of mechanical forces and cellular physiology.

The main fields of study covered by Discher include Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Within these broad fields, their work extends into several subfields, such as Immunology, Molecular Biology, Cell Biology, Physiology, and Surgery.

Discher's research addresses a variety of scientific topics. Notable focus areas include Phagocytosis and Immune Regulation, Cellular Mechanics and Interactions, Nuclear Structure and Function, Immune cells in cancer, RNA Research and Splicing, Erythrocyte Function and Pathophysiology, and Immunotherapy and Immune Responses.

Publication venues where Discher has frequently contributed include:

  • Biophysical Journal (24 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (12 publications)
  • Cancer Research (5 publications)
  • Bioconjugate Chemistry (2 publications)
  • Journal of Cell Science (2 publications)

Prominent frequent co-authors working alongside Discher include:

  • Lawrence J. Dooling (29 collaborations)
  • Michael P. Tobin (26 collaborations)
  • Jason C. Andrechak (23 collaborations)
  • Brandon H. Hayes (20 collaborations)
  • Manasvita Vashisth (17 collaborations)

Examples of recent papers authored or co-authored by Discher are:

  • "Challenges and opportunities for the next generation of cardiovascular tissue engineering," 2022, Nature Methods
  • "Macrophage checkpoint blockade: results from initial clinical trials, binding analyses, and CD47-SIRPα structure-function," 2020, Antibody Therapeutics
  • "Macrophages show higher levels of engulfment after disruption of cis interactions between CD47 and the checkpoint receptor SIRPα," 2020, Journal of Cell Science
  • "Cooperative phagocytosis of solid tumours by macrophages triggers durable anti-tumour responses," 2023, Nature Biomedical Engineering
  • "Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects," 2024, bioRxiv (Cold Spring Harbor Laboratory)

Among recognitions received during their career are the fellowship of the American Association for the Advancement of Science awarded in 2015, and membership in the National Academy of Engineering since 2012, the latter awarded for elucidation of the effects of mechanical forces on cell physiology and stem cell development.

Best Publications

  • Matrix elasticity directs stem cell lineage specification.

    Adam J. Engler;Shamik Sen;H. Lee Sweeney;Dennis E. Discher

  • Tissue Cells Feel and Respond to the Stiffness of Their Substrate

    Dennis E. Discher;Paul Janmey;Yu Li Wang

  • Polymer vesicles : Materials science: Soft surfaces

    Dennis E. Discher;Adi Eisenberg

  • Growth Factors, Matrices, and Forces Combine and Control Stem Cells

    Dennis E. Discher;David J. Mooney;Peter W. Zandstra

  • Shape effects of filaments versus spherical particles in flow and drug delivery.

    Yan Geng;Paul Dalhaimer;Shenshen Cai;Richard Tsai

  • Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments

    Adam J. Engler;Maureen A. Griffin;Shamik Sen;Carsten G. Bönnemann

  • Nuclear lamin-A Scales With Tissue Stiffness and Enhances Matrix-Directed Differentiation

    Joe Swift;Irena L. Ivanovska;Amnon Buxboim;Takamasa Harada

  • Mesenchymal stem cell perspective: cell biology to clinical progress

    Mark F. Pittenger;Dennis E. Discher;Bruno M. Péault;Donald G. Phinney

  • Substrate Compliance versus Ligand Density in Cell on Gel Responses

    Adam Engler;Lucie Bacakova;Cynthia Newman;Alina Hategan

  • Bio-inspired, bioengineered and biomimetic drug delivery carriers

    Jin-Wook Yoo;Darrell J. Irvine;Darrell J. Irvine;Darrell J. Irvine;Dennis E. Discher;Samir Mitragotri

  • Mitotic progression following DNA damage enables pattern recognition within micronuclei

    Shane M. Harding;Joseph L. Benci;Jerome Irianto;Dennis E. Discher

  • Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

    Pia L. Rodriguez;Takamasa Harada;David A. Christian;Diego A. Pantano

  • Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating

    Adam J. Engler;Christine Carag-Krieger;Colin P. Johnson;Matthew Raab

  • Physical plasticity of the nucleus in stem cell differentiation

    J. David Pajerowski;Kris Noel Dahl;Franklin L. Zhong;Paul J. Sammak

  • Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance

    Mark F. Berry;Adam J. Engler;Y. Joseph Woo;Timothy J. Pirolli

  • Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival

    Takamasa Harada;Joe Swift;Jerome Irianto;Jae Won Shin

  • Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.

    Fariyal Ahmed;Dennis E Discher

  • Molecular Weight Dependence of Polymersome Membrane Structure, Elasticity, and Stability

    Harry Bermudez;Aaron K. Brannan;Daniel A. Hammer;Frank S. Bates

  • Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug

    Fariyal Ahmed;Refika I. Pakunlu;Aaron Brannan;Frank Bates

  • Polymer vesicles in vivo: correlations with PEG molecular weight.

    Peter J. Photos;Lucie Bacakova;Bohdana Discher;Frank S. Bates

Frequent Co-Authors

Frank S. Bates
Frank S. Bates University of Minnesota
Adam J. Engler
Adam J. Engler University of California, San Diego
David W. Speicher
David W. Speicher The Wistar Institute
Roger A. Greenberg
Roger A. Greenberg University of Pennsylvania
Michael L. Klein
Michael L. Klein Temple University
Paul A. Janmey
Paul A. Janmey University of Pennsylvania
Daniel A. Hammer
Daniel A. Hammer University of Pennsylvania
H. Lee Sweeney
H. Lee Sweeney University of Florida
Samuel A. Safran
Samuel A. Safran Weizmann Institute of Science
Catherine Picart
Catherine Picart Grenoble Alpes University

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