What is he best known for?
The fields of study he is best known for:
His primary scientific interests are in Biochemistry, Proteome, Molecular biology, Spectrin and Cell biology.
David W. Speicher regularly links together related areas like Antibody in his Biochemistry studies.
His research integrates issues of Blood proteins, Chromatography, Mass spectrometry and Proteomics in his study of Proteome.
His research in Molecular biology intersects with topics in Amino acid, Cyclophilin, Affinity chromatography and Melanoma-associated antigen.
His Spectrin research is multidisciplinary, incorporating perspectives in Protein structure, Cleavage, Peptide and Protein folding.
His Cell biology research incorporates themes from Corepressor, Genetics, Cellular differentiation and Zinc finger.
His most cited work include:
- Cyclophilin: a specific cytosolic binding protein for cyclosporin A. (1398 citations)
- Nuclear lamin-A Scales With Tissue Stiffness and Enhances Matrix-Directed Differentiation (1087 citations)
- Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database. (707 citations)
What are the main themes of his work throughout his whole career to date?
David W. Speicher mainly focuses on Biochemistry, Cell biology, Spectrin, Molecular biology and Chromatography.
His research investigates the connection with Cell biology and areas like Autophagy which intersect with concerns in Cancer research.
His Spectrin research includes elements of Protein structure, Biophysics and Tetramer.
In his study, which falls under the umbrella issue of Molecular biology, Antigen is strongly linked to Antibody.
His Chromatography study integrates concerns from other disciplines, such as Isoelectric focusing, Proteome, Membrane and Proteomics.
His Proteome research is multidisciplinary, incorporating elements of Tandem mass spectrometry, Mass spectrometry, Blood proteins, Protein profiling and Computational biology.
He most often published in these fields:
- Biochemistry (29.41%)
- Cell biology (19.61%)
- Spectrin (20.73%)
What were the highlights of his more recent work (between 2013-2021)?
- Cancer research (13.45%)
- Cell biology (19.61%)
- Cancer (5.88%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Cancer research, Cell biology, Cancer, Biochemistry and Melanoma.
His study in Cancer research is interdisciplinary in nature, drawing from both Tumor microenvironment, Cancer cell, Immunology, Metastasis and Programmed cell death.
His studies deal with areas such as Autophagy and Carcinogenesis as well as Cell biology.
His Cancer research focuses on EZH2 and how it connects with ARID1A.
His study in Spectrin, Protein structure, Glutathione, Enzyme and Membrane protein are all subfields of Biochemistry.
The Spectrin study combines topics in areas such as Mutation, Biophysics, Mutant, Protein quaternary structure and Heterotetramer.
Between 2013 and 2021, his most popular works were:
- Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A -mutated cancers (358 citations)
- Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors (217 citations)
- sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance (171 citations)
In his most recent research, the most cited papers focused on:
David W. Speicher focuses on Cancer research, Cell biology, Cancer, Autophagy and Biochemistry.
His Cancer research research integrates issues from Tumor microenvironment, Cancer cell, Immunology, Signal transduction and Tumor progression.
His research is interdisciplinary, bridging the disciplines of Regulation of gene expression and Cell biology.
David W. Speicher has researched Cancer in several fields, including PI3K/AKT/mTOR pathway and EZH2.
His Biochemistry study frequently draws connections between related disciplines such as Antiparallel.
His study looks at the relationship between Cytoplasm and topics such as Kinase, which overlap with RNA, RNA editing and Molecular biology.
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