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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
13242
World Ranking
11932
National Ranking
5123

Overview

Rugang Zhang is affiliated with The Wistar Institute in the United States and has a research portfolio spanning biochemistry, genetics and molecular biology, medicine, and immunology and microbiology. Their work extensively covers molecular biology, immunology, oncology, radiology, nuclear medicine and imaging, as well as pathology and forensic medicine.

The main topics Rugang Zhang investigates include chromatin remodeling and cancer, immune cells in cancer, cancer mechanisms and therapy, RNA modifications and cancer, immunotherapy and immune responses, epigenetics and DNA methylation, and interferon and immune responses.

Recent papers by Rugang Zhang include:

  • Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models, 2020, Nature Communications
  • Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils, 2020, Science Translational Medicine
  • Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy, 2020, Journal of Clinical Investigation
  • m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype, 2021, Nature Cell Biology
  • EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition, 2020, Cancer Cell

Frequent co-authors with Zhang include Andrew V. Kossenkov, Hao Xue, Jianhuang Lin, Wei Zhou, and Hao Nie.

The most common venues where Rugang Zhang's research appears are:

  • Cancer Research
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Regular and Young Investigator Award Abstracts

Best Publications

  • Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

    Rugang Zhang;Maxim V. Poustovoitov;Maxim V. Poustovoitov;Xiaofen Ye;Hidelita A. Santos

  • Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A -mutated cancers

    Benjamin G. Bitler;Katherine M. Aird;Azat Garipov;Hua Li

  • Molecular Dissection of Formation of Senescence-Associated Heterochromatin Foci

    Rugang Zhang;Wei Chen;Peter D. Adams

  • BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression.

    Hengrui Zhu;Fee Bengsch;Nikolaos Svoronos;Melanie R. Rutkowski

  • sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

    Amanpreet Kaur;Amanpreet Kaur;Marie R. Webster;Katie Marchbank;Reeti Behera

  • Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation

    Melanie R. Rutkowski;Tom L. Stephen;Nikolaos Svoronos;Michael J. Allegrezza

  • NAD+ metabolism governs the proinflammatory senescence-associated secretome

    Timothy Nacarelli;Lena Lau;Takeshi Fukumoto;Joseph Zundell

  • Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

    Katherine M. Aird;Gao Zhang;Hua Li;Zhigang Tu

  • Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells

    Xiaofen Ye;Brad Zerlanko;Alyssa Kennedy;Gowrishankar Banumathy

  • Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models

    Hyoung Kim;Erin George;Ryan L. Ragland;Stavros Rafail

  • Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

    Hyoung Kim;Haineng Xu;Erin George;Dorothy Hallberg

  • Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.

    Alyssa L. Kennedy;Jennifer P. Morton;Indrani Manoharan;David M. Nelson

  • ARID1A -mutated ovarian cancers depend on HDAC6 activity

    Benjamin G. Bitler;Shuai Wu;Pyoung Hwa Park;Yang Hai

  • PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion

    M. Cecilia Caino;Jagadish C. Ghosh;Young Chan Chae;Valentina Vaira

  • Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers

    Jiao Yuan;Zhongyi Hu;Brandon A. Mahal;Sihai Dave Zhao

  • Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci

    Xiaofen Ye;Brad Zerlanko;Rugang Zhang;Neeta Somaiah

  • Tumor Cell-Independent Estrogen Signaling Drives Disease Progression Through Mobilization of Myeloid-Derived Suppressor Cells

    Nikolaos Svoronos;Alfredo Perales-Puchalt;Michael J. Allegrezza;Melanie R. Rutkowski

  • Nucleotide Metabolism, Oncogene-Induced Senescence and Cancer

    Katherine M. Aird;Rugang Zhang

  • BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer

    Sergey Karakashev;Hengrui Zhu;Yuhki Yokoyama;Bo Zhao

  • Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

    Shuyun Rao;Sang-Yun Lee;Alejandro Gutierrez;Jacqueline Perrigoue

Frequent Co-Authors

Andrew V. Kossenkov
Andrew V. Kossenkov The Wistar Institute
David W. Speicher
David W. Speicher The Wistar Institute
Peter D. Adams
Peter D. Adams Sanford Burnham Prebys Medical Discovery Institute
Jose R. Conejo-Garcia
Jose R. Conejo-Garcia Duke University
Lin Zhang
Lin Zhang University of Pennsylvania
Ronny Drapkin
Ronny Drapkin University of Pennsylvania
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Gordon B. Mills
Gordon B. Mills Oregon Health & Science University
Ie Ming Shih
Ie Ming Shih Johns Hopkins University
Louise C. Showe
Louise C. Showe The Wistar Institute

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