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Kenneth P. Nephew

Kenneth P. Nephew

D-Index & Metrics

Medicine

D-Index
83
Citations
23607
World Ranking
15680
National Ranking
7889

Overview

Kenneth P. Nephew is affiliated with Indiana University in the United States and has an extensive research portfolio focused on molecular biology and cancer studies. Their work contributes primarily to the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular emphasis on cancer research and related molecular mechanisms.

The scientist's research topics include:

  • Epigenetics and DNA Methylation
  • Cancer-related molecular mechanisms research
  • MicroRNA in disease regulation
  • Cancer Cells and Metastasis
  • Ovarian cancer diagnosis and treatment
  • RNA modifications and cancer
  • RNA Research and Splicing

Kenneth P. Nephew has contributed to several recent scientific papers, addressing diverse aspects of cancer biology and therapeutic targets. Notable publications include:

  • "Glutamine metabolism in breast cancer and possible therapeutic targets," 2023, Biochemical Pharmacology
  • "Epigenetic Attire in Ovarian Cancer: The Emperor's New Clothes," 2020, Cancer Research
  • "EZH2-Mediated Downregulation of the Tumor Suppressor DAB2IP Maintains Ovarian Cancer Stem Cells," 2020, Cancer Research
  • "Platinum-induced mitochondrial OXPHOS contributes to cancer stem cell enrichment in ovarian cancer," 2022, Journal of Translational Medicine
  • "Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies," 2020, Cancers

The scientist's frequent co-authors include Heather M. O'Hagan, Fang Fang, Weini Wang, George E. Sandusky, and Feyruz V. Rassool, collaborating extensively on cancer research projects.

Research outputs are predominantly published in the following venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research
  • npj Precision Oncology
  • Cancers

Kenneth P. Nephew's scientific contributions cover a wide range of subfields within biomedical research, including Molecular Biology, Cancer Research, Oncology, Reproductive Medicine, and Immunology.

Best Publications

  • Identification and characterization of ovarian cancer-initiating cells from primary human tumors.

    Shu Zhang;Curt Balch;Michael W. Chan;Hung Cheng Lai

  • Rethinking ovarian cancer: recommendations for improving outcomes

    Sebastian Vaughan;Jermaine I. Coward;Robert C. Bast;Andy Berchuck

  • Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

    David D. Bowtell;David D. Bowtell;Steffen Böhm;Ahmed A. Ahmed;Paul Joseph Aspuria

  • EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

    Michela Garofalo;Giulia Romano;Gianpiero Di Leva;Gerard Nuovo

  • MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways

    X Rao;G Di Leva;M Li;F Fang

  • Epigenetic Resensitization to Platinum in Ovarian Cancer

    Daniela Matei;Fang Fang;Changyu Shen;Jeanne Schilder

  • MicroRNA Cluster 221-222 and Estrogen Receptor α Interactions in Breast Cancer

    Gianpiero Di Leva;Pierluigi Gasparini;Claudia Piovan;Apollinaire Ngankeu

  • Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation

    Yunlong Liu;Yokesh Balaraman;Guohua Wang;Guohua Wang;Kenneth P. Nephew

  • Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant

    Meiyun Fan;Pearlly S. Yan;Cori Hartman-Frey;Lei Chen

  • Epigenetic gene silencing in cancer initiation and progression

    Kenneth P. Nephew;Tim Hui Ming Huang

  • NF-κB-HOTAIR Axis Links DNA Damage Response, Chemoresistance and Cellular Senescence in Ovarian Cancer

    Ali R. Özeş;David F. Miller;Osman N. Özeş;Fang Fang

  • Epithelial ovarian cancer experimental models.

    E. Lengyel;J. E. Burdette;H. A. Kenny;Daniela Matei

  • Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer

    Meng Li;Curt Balch;John S Montgomery;Mikyoung Jeong

  • Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers

    Susan H. Wei;Chuan Mu Chen;Gordon Strathdee;Jaturon Harnsomburana

  • Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer

    Yu Wei Leu;Pearlly S. Yan;Meiyun Fan;Victor X. Jin

  • Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters

    Alfred S.L. Cheng;Victor X. Jin;Meiyun Fan;Laura T. Smith

  • Fulvestrant (ICI 182,780)-dependent Interacting Proteins Mediate Immobilization and Degradation of Estrogen Receptor-α *

    Xinghua Long;Kenneth P. Nephew

  • CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-α

    Meiyun Fan;Annie Park;Kenneth P. Nephew

  • MicroRNA and mRNA integrated analysis (MMIA): a web tool for examining biological functions of microRNA expression.

    Seungyoon Nam;Meng Li;Kwangmin Choi;Curtis Balch

  • Minireview: Epigenetic Changes in Ovarian Cancer

    Curt Balch;Fang Fang;Daniela E. Matei;Tim H.-M. Huang

Frequent Co-Authors

Tim H M Huang
Tim H M Huang The University of Texas Health Science Center at San Antonio
Yunlong Liu
Yunlong Liu Indiana University
Pearlly S. Yan
Pearlly S. Yan The Ohio State University
Changyu Shen
Changyu Shen Chinese Academy of Sciences
Ramana V. Davuluri
Ramana V. Davuluri Stony Brook University
Harikrishna Nakshatri
Harikrishna Nakshatri Indiana University
Victor X. Jin
Victor X. Jin Medical College of Wisconsin
Sandya Liyanarachchi
Sandya Liyanarachchi The Ohio State University
Ernst Lengyel
Ernst Lengyel University of Chicago
Erik K. Flemington
Erik K. Flemington Tulane University

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