James D. Brenton

Best Publications

• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

  Christina Curtis;Christina Curtis;Sohrab P Shah;Suet-Feung Chin;Gulisa Turashvili

  6086
  Citations

• Liquid biopsies come of age: towards implementation of circulating tumour DNA

  Jonathan C. M. Wan;Charles E. Massie;Javier Garcia-Corbacho;Florent Mouliere

  2215
  Citations

• Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

  Muhammed Murtaza;Sarah-Jane Dawson;Dana W. Y. Tsui;Davina Gale

  1615
  Citations

• Rethinking ovarian cancer: recommendations for improving outcomes

  Sebastian Vaughan;Jermaine I. Coward;Robert C. Bast;Andy Berchuck

  1608
  Citations

• Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

  Tim Forshew;Muhammed Murtaza;Christine Parkinson;Christine Parkinson;Davina Gale

  1446
  Citations

• Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

  David D. Bowtell;David D. Bowtell;Steffen Böhm;Ahmed A. Ahmed;Paul Joseph Aspuria

  1334
  Citations

• Molecular Classification and Molecular Forecasting of Breast Cancer: Ready for Clinical Application?

  James D. Brenton;Lisa A. Carey;Ahmed Ashour Ahmed;Carlos Caldas

  1283
  Citations

• Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial

  Elizabeth M Swisher;Kevin K Lin;Amit M Oza;Clare L Scott

  1159
  Citations

• Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

  Ahmed Ashour Ahmed;Dariush Etemadmoghadam;Jillian Temple;Andy G Lynch

  860
  Citations

• Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary

  Sohrab P Shah;Martin Köbel;Janine Senz;Ryan D Morin

  827
  Citations

• Enhanced detection of circulating tumor DNA by fragment size analysis

  Florent Mouliere;Dineika Chandrananda;Anna M. Piskorz;Elizabeth K. Moore;Elizabeth K. Moore

  810
  Citations

• CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

  Hong Xu;Marco Di Antonio;Steven McKinney;Veena Mathew

  481
  Citations

• Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

  Weiva Sieh;Martin Köbel;Teri A Longacre;David D Bowtell;David D Bowtell

  467
  Citations

• Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

  Catherine M Phelan;Karoline B Kuchenbaecker;Karoline B Kuchenbaecker;Jonathan P Tyrer;Siddhartha P Kar

  457
  Citations

• Regulators of Mitotic Arrest and Ceramide Metabolism Are Determinants of Sensitivity to Paclitaxel and Other Chemotherapeutic Drugs

  Charles Swanton;Michela Marani;Olivier Pardo;Patricia H. Warne

  449
  Citations

• GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

  Paul D.P. Pharoah;Ya Yu Tsai;Susan J. Ramus;Catherine M. Phelan

  420
  Citations

• Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic analysis.

  Roland F. Schwarz;Charlotte K. Y. Ng;Susanna L. Cooke;Scott Newman

  415
  Citations

• High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer.

  Suet F Chin;Andrew E Teschendorff;John C Marioni;Yanzhong Wang

  403
  Citations

• Ovarian cancer cell line panel (OCCP): Clinical importance of in vitro morphological subtypes

  Corine M. Beaufort;Jean C. A. Helmijr;Anna M. Piskorz;Marlous Hoogstraat

  400
  Citations

• The External RNA Controls Consortium: a progress report.

  Shawn C Baker;Steven R Bauer;Richard P Beyer;James D Brenton

  398
  Citations