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Diether Lambrechts

Diether Lambrechts

D-Index & Metrics

Medicine

D-Index
130
Citations
76101
World Ranking
2460
National Ranking
27

Overview

Diether Lambrechts is affiliated with KU Leuven in Belgium and conducts research primarily in the fields of medicine and biochemistry, genetics, and molecular biology. Their scientific work focuses extensively on oncology, molecular biology, cancer research, immunology, and genetics, addressing key challenges in cancer biology and treatment.

The scope of Lambrechts's research includes several main topics such as cancer genomics and diagnostics, cancer immunotherapy and biomarkers, single-cell and spatial transcriptomics, immune cells in cancer, BRCA gene mutations in cancer, immune cell function and interaction, and ovarian cancer diagnosis and treatment.

Frequent coauthors with whom Lambrechts has collaborated include Bram Boeckx, Thomas Van Brussel, Peter A. Fasching, Thilo Dörk, and Giuseppe Floris. These collaborations are reflected in extensive publications across various high-impact journals and research venues.

The publication record demonstrates a strong presence in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Annals of Oncology, Clinical Cancer Research, and UNC Libraries. This distribution indicates active engagement with the cancer research community and contributions to advancing knowledge in related fields.

Among recent papers authored by collaborations involving Lambrechts, the following are highlighted with their year of publication and venue:

  • Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer, 2020, Nature Genetics
  • A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer, 2021, Nature Medicine
  • A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling, 2020, Cell Research
  • Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization, 2021, Nature Neuroscience
  • An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates, 2020, Cancer Cell

Best Publications

  • Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study

    Benjamin F. Voight;Benjamin F. Voight;Benjamin F. Voight;Gina M. Peloso;Gina M. Peloso;Marju Orho-Melander;Ruth Frikke-Schmidt

  • Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

    Heribert Schunkert;Inke R. König;Sekar Kathiresan;Muredach P. Reilly

  • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis

    Wendy De Roock;Bart Claes;David Bernasconi;Jef De Schutter

  • Phenotype molding of stromal cells in the lung tumor microenvironment.

    Diether Lambrechts;Els Wauters;Bram Boeckx;Sara Aibar

  • Association analysis identifies 65 new breast cancer risk loci

    Kyriaki Michailidou;Kyriaki Michailidou;Sara Lindström;Sara Lindström;Joe Dennis;Jonathan Beesley

  • Large-scale genotyping identifies 41 new loci associated with breast cancer risk

    Kyriaki Michailidou;Per Hall;Anna Gonzalez-Neira;Maya Ghoussaini

  • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial

    Timothyn Stanley Maughan;Richard Alexander Adams;Chris Smith;Angela M. Meade

  • Gene prioritization through genomic data fusion.

    Stein Aerts;Diether Lambrechts;Sunit Maity;Peter Van Loo

  • VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

    Diether Lambrechts;Erik Storkebaum;Masafumi Morimoto;Jurgen Del-Favero

  • Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

    Monica Autiero;Johannes Waltenberger;Didier Communi;Andrea Kranz

  • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

    Nasim Mavaddat;Kyriaki Michailidou;Kyriaki Michailidou;Joe Dennis;Michael Lush

  • Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies

    Xiaohong R. Yang;Jenny Chang-Claude;Ellen L. Goode;Fergus J. Couch

  • Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk

    Ganna Chornokur;Hui-Yi Lin;Jonathan P. Tyrer;Kate Lawrenson

  • Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer

    Kelly L. Bolton;Kelly L. Bolton;Georgia Chenevix-Trench;Cindy Goh;Siegal Sadetzki

  • Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

    John R.B. Perry;Felix Day;Cathy E. Elks;Patrick Sulem

  • VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection

    Erik Storkebaum;Diether Lambrechts;Peter Carmeliet

  • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

    Kyriaki Michailidou;Jonathan Beesley;Sara Lindstrom;Sander Canisius

  • Thrombomodulin mutations in atypical hemolytic-uremic syndrome.

    Mieke Delvaeye;Marina Noris;Astrid De Vriese;Charles T. Esmon

  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

    Stig E. Bojesen;Stig E. Bojesen;Karen A. Pooley;Sharon E. Johnatty;Jonathan Beesley

  • Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants

    Nasim Mavaddat;Paul D.P. Pharoah;Kyriaki Michailidou;Jonathan Tyrer

Frequent Co-Authors

Graham G. Giles
Graham G. Giles University of Melbourne
Jenny Chang-Claude
Jenny Chang-Claude German Cancer Research Center
Hiltrud Brauch
Hiltrud Brauch German Cancer Research Center
Paul D.P. Pharoah
Paul D.P. Pharoah University of Cambridge
Roger L. Milne
Roger L. Milne Cancer Council Victoria
Matthias W. Beckmann
Matthias W. Beckmann University of Erlangen-Nuremberg
Melissa C. Southey
Melissa C. Southey Monash University
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Douglas F. Easton
Douglas F. Easton University of Cambridge
Thilo Dörk
Thilo Dörk Hannover Medical School

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