World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
79
Citations
29844
World Ranking
1623
National Ranking
748

Molecular Biology

D-Index
79
Citations
29844
World Ranking
1027
National Ranking
541

Overview

Frank J. Rauscher is affiliated with The Wistar Institute in the United States. Their research spans multiple key areas within medicine, biochemistry, genetics, and molecular biology. The primary fields of study include molecular biology and oncology, with specific focus areas in endocrinology, diabetes and metabolism, as well as pulmonary and respiratory medicine.

Rauscher's work addresses several topics, reflecting a focus on cancer-related molecular pathways and mechanisms. These topics include:

  • Cancer-related Molecular Pathways
  • Ubiquitin and proteasome pathways
  • Thyroid Cancer Diagnosis and Treatment
  • Wnt/β-catenin signaling in development and cancer
  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • Cancer Cells and Metastasis

Recent publications by Rauscher demonstrate involvement in the characterization of molecular and cellular mechanisms linked to cancer and gene regulation. These include:

  • "LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk," 2020, published in Cells
  • "Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase," 2021, published in Molecular Cancer Research
  • "Twist, Snail, and Sox9 form an allosterically regulated complex, the EMTosome, on a bipartite E-box site," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Kinetics characterization of ASXL1/2-mediated allosteric regulation of BAP1 deubiquitinase," 2020, published in bioRxiv (Cold Spring Harbor Laboratory)

The most frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Cells, and Molecular Cancer Research.

Collaboration plays a significant role in Rauscher's research, with frequent co-authors contributing across multiple projects. Notable collaborators include:

  • Hongzhuang Peng
  • Daniel S. McCracken
  • Kasirajan Ayyanathan
  • Eileen J. Kennedy
  • Joel Cassel

Best Publications

  • SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

    David C. Schultz;Kasirajan Ayyanathan;Dmitri Negorev;Gerd G. Maul

  • Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.

    N Galili;R J Davis;W J Fredericks;S Mukhopadhyay

  • BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

    David E. Jensen;Monja Proctor;Sandra T. Marquis;Heather Perry Gardner

  • Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

    Frank J. Rauscher;Jennifer F. Morris;Olivia E. Tournay;Donna M. Cook

  • KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

    Josh R. Friedman;William J. Fredericks;David E. Jensen;David W. Speicher

  • Fos-associated protein p39 is the product of the jun proto-oncogene.

    Frank J. Rauscher;Donna R. Cohen;Tom Curran;Timothy J. Bos

  • Regulation of Proenkephalin by Fos and Jun

    June L. Sonnenberg;Frank J. Rauscher;James I. Morgan;Tom Curran

  • Krüppel-associated boxes are potent transcriptional repression domains.

    Judith F. Margolin;Josh R. Friedman;Wolfram K. H. Meyer;Henrik Vissing

  • Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD

    David C. Schultz;Josh R. Friedman;Frank J. Rauscher

  • Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1.

    IA Drummond;SL Madden;P Rohwer-Nutter;GI Bell

  • Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

    Stephen L. Madden;Donna M. Cook;Jennifer F. Morris;Andrea Gashler

  • KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for Krüppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing.

    Robert F. Ryan;David C. Schultz;Kasirajan Ayyanathan;Prim B. Singh

  • Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

    Kasirajan Ayyanathan;Mark S. Lechner;Peter Bell;Gerd G. Maul

  • Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

    Haim Werner;Eddy Karnieli;Frank J. Rauscher;Derek Leroith

  • PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing.

    Alexey V. Ivanov;Hongzhuang Peng;Vyacheslav Yurchenko;Kyoko L. Yap

  • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.

    W. J. Fredericks;Naomi Galili;Sunil Mukhopadhyay;G. Rovera

  • Physical and functional interaction between WT1 and p53 proteins.

    Shyamala Maheswaran;Seon Park;Amy Bernard;Jennifer F. Morris

  • Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product.

    H Werner;G G Re;I A Drummond;V P Sukhatme

  • The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor.

    Frank J. Rauscher

  • Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

    Andrea L. Gashler;David T. Bonthron;Stephen L. Madden;Frank J. Rauscher

Frequent Co-Authors

Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
David W. Speicher
David W. Speicher The Wistar Institute
Gerd G. Maul
Gerd G. Maul The Wistar Institute
Joseph R. Testa
Joseph R. Testa Fox Chase Cancer Center
Vikas P. Sukhatme
Vikas P. Sukhatme Emory University
Katherine L. B. Borden
Katherine L. B. Borden Northwestern University
Tom Curran
Tom Curran Children's Mercy Hospital
Gregory D. Longmore
Gregory D. Longmore Washington University in St. Louis
Andrew J. Caton
Andrew J. Caton The Wistar Institute
Electron Kebebew
Electron Kebebew Stanford University

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