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Biology and Biochemistry

D-Index
130
Citations
63402
World Ranking
405
National Ranking
262

Overview

Carlos F. Barbas was affiliated with the Scripps Research Institute in the United States. Their research contributions primarily spanned the fields of biochemistry, genetics, and molecular biology, with a focus on several specialized subfields including molecular biology, radiology, nuclear medicine and imaging, biomaterials, and virology.

Their published work included topics related to monoclonal and polyclonal antibodies research, glycosylation and glycoproteins research, nanoparticle-based drug delivery, CRISPR and genetic engineering, RNA interference and gene delivery, as well as HIV research and treatment.

  • Highly Specific Blood-Brain Barrier Transmigrating Single-Domain Antibodies Selected by an In Vivo Phage Display Screening (2021, Pharmaceutics)
  • Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells (2020, Molecular Therapy - Methods & Clinical Development)

The scientist regularly collaborated with several co-authors over their career. Frequent collaborators included:

  • João Gonçalves
  • Sandra I. Aguiar
  • Joana Dias
  • A André
  • Marta Silva

Barbas's publications appeared in notable scientific venues such as Pharmaceutics and Molecular Therapy - Methods & Clinical Development. Their research outputs in these journals reflected intersections between molecular biology techniques and therapeutic delivery systems, particularly focusing on antibody engineering and HIV treatment strategies.

Their work in nanoparticle-based drug delivery and gene delivery mechanisms contributed to the understanding of targeted therapeutic approaches. This included innovative methods for crossing biological barriers and stimulating viral activation in latent infections.

Throughout their career, the scientist focused on advancing molecular biology applications related to genetic engineering and immune system modulation. Their interdisciplinary collaborations and contributions across multiple fields helped characterize complex biological systems, integrating molecular insights with clinical development themes.

Best Publications

  • ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

    Thomas Gaj;Charles A. Gersbach;Carlos F. Barbas

  • Proline-Catalyzed Direct Asymmetric Aldol Reactions

    Benjamin List;Richard A. Lerner;Carlos F. Barbas

  • Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

    Carlos F. Barbas;Angray S. Kang;Richard A. Lerner;Stephen J. Benkovic

  • Amino Acid Catalyzed Direct Asymmetric Aldol Reactions: A Bioorganic Approach to Catalytic Asymmetric Carbon-Carbon Bond-Forming Reactions

    Kandasamy Sakthivel;Wolfgang Notz;Tommy Bui;Carlos F. Barbas

  • De novo computational design of retro-aldol enzymes.

    Lin Jiang;Eric A. Althoff;Fernando R. Clemente;Lindsey Doyle

  • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

    Dennis R. Burton;Jayashree Pyati;Raju Koduri;Stephen J. Sharp

  • Phage Display : A Laboratory Manual

    Carlos F. Barbas

  • The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation

    Thomas Holbro;Roger R. Beerli;Francisca Maurer;Magdalena Koziczak

  • Heterodimeric receptor libraries using phagemids

    Angray Kang;Carlos F. Barbas;Richard A. Lerner

  • A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

    Dennis R. Burton;Carlos F. Barbas;Mats A. A. Persson;Scott Koenig

  • Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

    Roger R. Beerli;David J. Segal;Birgit Dreier;Carlos F. Barbas

  • Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

    Angray S. Kang;Carlos F. Barbas;Kim D. Janda;Stephen J. Benkovic

  • Engineering polydactyl zinc-finger transcription factors.

    Roger R. Beerli;Carlos F. Barbas

  • Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem

    Carlos F. Barbas;J. D. Bain;Denise M. Hoekstra;Richard A. Lerner

  • Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

    A Trkola;A B Pomales;H Yuan;B Korber

  • Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.

    J. P. Moore;Yunzhen Cao;Limo Qing;Q. J. Sattentau

  • CDR Walking Mutagenesis for the Affinity Maturation of a Potent Human Anti-HIV-1 Antibody into the Picomolar Range

    Wei-Ping Yang;Kimberly Green;Sally Pinz-Sweeney;Amelia T. Briones

  • Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences.

    David J. Segal;Birgit Dreier;Roger R. Beerli;Carlos F. Barbas

  • In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library.

    Hermann Gram;Lori-Anne Marconi;Carlos F. Barbas Iii;Thomas A. Collet

  • Efficient aldolase catalytic antibodies that use the enamine mechanism of natural enzymes

    Jürgen Wagner;Richard A. Lerner;Carlos F. Barbas

Frequent Co-Authors

Richard A. Lerner
Richard A. Lerner Scripps Research Institute
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Fujie Tanaka
Fujie Tanaka Okinawa Institute of Science and Technology
Christoph Rader
Christoph Rader Scripps Research Institute
Benjamin List
Benjamin List Max Planck Society
Guofu Zhong
Guofu Zhong Hangzhou Normal University
Bin Tan
Bin Tan Southern University of Science and Technology
Doron Shabat
Doron Shabat Tel Aviv University
David J. Segal
David J. Segal University of California, Davis
Dhevalapally B. Ramachary
Dhevalapally B. Ramachary University of Hyderabad

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