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Chemistry

D-Index
116
Citations
63529
World Ranking
582
National Ranking
246

Biology and Biochemistry

D-Index
130
Citations
75127
World Ranking
399
National Ranking
260

Research.com Recognitions

  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2000 - Fellow of the American Academy of Arts and Sciences
  • 1991 - Member of the National Academy of Sciences

Overview

Richard A. Lerner was affiliated with the Scripps Research Institute in the United States. Their research spanned multiple fields, primarily within medicine and biochemistry, genetics, and molecular biology. They contributed significantly to subfields such as molecular biology, organic chemistry, oncology, radiology, nuclear medicine, imaging, and biomedical engineering.

Their work addressed a variety of scientific topics, including:

  • Monoclonal and polyclonal antibodies research
  • CAR-T cell therapy research
  • Nanowire synthesis and applications
  • Catalytic C-H functionalization methods
  • Click chemistry and applications
  • Glycosylation and glycoproteins research
  • Chemical synthesis and analysis

Richard A. Lerner's published papers included studies that appeared in prominent journals across different disciplines. Notable recent publications included:

  • Studies on the mechanism of general anesthesia, 2020, Proceedings of the National Academy of Sciences
  • gem-Difluoromethylene Alkyne-Enabled Diverse C−H Functionalization and Application to the on-DNA Synthesis of Difluorinated Isocoumarins, 2020, Angewandte Chemie International Edition
  • A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries, 2020, Angewandte Chemie International Edition
  • Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications, 2021, Nature Chemistry
  • Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses, 2020, Science

Frequent collaborators included:

  • Guang Yang (16 publications)
  • Peixiang Ma (11 publications)
  • Hongtao Xu (10 publications)
  • Jia Xie (8 publications)
  • Yuang Gu (7 publications)

The venues where Richard A. Lerner published most often included:

  • Proceedings of the National Academy of Sciences (5 publications)
  • Angewandte Chemie International Edition (3 publications)
  • Advanced Science (3 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • Angewandte Chemie (3 publications)

Throughout their career, Richard A. Lerner received recognition through memberships and fellowships, such as being a Fellow of the American Association for the Advancement of Science in 2004, a Fellow of the American Academy of Arts and Sciences in 2000, and a Member of the National Academy of Sciences since 1991.

Best Publications

  • Proline-Catalyzed Direct Asymmetric Aldol Reactions

    Benjamin List;Richard A. Lerner;Carlos F. Barbas

  • Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda

    William D. Huse;Lakshmi Sastry;Sheila A. Iverson;Angray S. Kang;Angray S. Kang

  • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

    Benjamin F. Cravatt;Dan K. Giang;Stephen P. Mayfield;Dale L. Boger

  • Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

    Carlos F. Barbas;Angray S. Kang;Richard A. Lerner;Stephen J. Benkovic

  • Encoded combinatorial chemistry.

    Sydney Brenner;Richard A. Lerner

  • Nucleotide sequence of Moloney murine leukaemia virus.

    Thomas M. Shinnick;Richard A. Lerner;J. Gregor Sutcliffe

  • The structure of an antigenic determinant in a protein

    Ian A. Wilson;Henry L. Niman;Richard A. Houghten;Andrew R. Cherenson

  • Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

    J. Field;J. Nikawa;D. Broek;B. MacDonald

  • Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

    James L. Bittle;Richard A. Houghten;Hannah Alexander;Thomas M. Shinnick

  • Folding of immunogenic peptide fragments of proteins in water solution: I. Sequence requirements for the formation of a reverse turn

    Dyson Hj;Rance M;Houghten Ra;Lerner Ra

  • Radioiodination of proteins in single polyacrylamide gel slices. Tryptic peptide analysis of all the major members of complex multicomponent systems using microgram quantities of total protein.

    J H Elder;R A Pickett nd;J Hampton;R A Lerner

  • Heterodimeric receptor libraries using phagemids

    Angray Kang;Carlos F. Barbas;Richard A. Lerner

  • A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

    Dennis R. Burton;Carlos F. Barbas;Mats A. A. Persson;Scott Koenig

  • The role of anti-glomerular basement membrane antibody in the pathogenesis of human glomerulonephritis.

    R A Lerner;R J Glassock;F J Dixon

  • At the crossroads of chemistry and immunology: Catalytic antibodies

    Richard A. Lerner;Stephen J. Benkovic;Peter G. Schultz

  • Immunogenic structure of the influenza virus hemagglutinin

    N Green;H Alexander;A Olson;S Alexander

  • Tapping the immunological repertoire to produce antibodies of predetermined specificity

    Richard A. Lerner

  • Mitotic misregulation and human aging.

    Danith H. Ly;David J. Lockhart;Richard A. Lerner;Peter G. Schultz;Peter G. Schultz

  • Chemical characterization of a family of brain lipids that induce sleep.

    Benjamin F. Cravatt;Oscar Prospero-Garcia;Gary Siuzdak;Norton B. Gilula

  • Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

    Angray S. Kang;Carlos F. Barbas;Kim D. Janda;Stephen J. Benkovic

Frequent Co-Authors

Carlos F. Barbas
Carlos F. Barbas Scripps Research Institute
Kim D. Janda
Kim D. Janda Scripps Research Institute
Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Fred Brown
Fred Brown United States Department of Agriculture
Benjamin List
Benjamin List Max Planck Society
Frank J. Dixon
Frank J. Dixon Scripps Health
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute

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