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Molecular Biology

D-Index
117
Citations
51568
World Ranking
288
National Ranking
172

Medicine

D-Index
118
Citations
52665
World Ranking
4051
National Ranking
2218

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Joseph R. Testa is affiliated with the Fox Chase Cancer Center in the United States. Their research primarily focuses on the fields of medicine and biochemistry, genetics, and molecular biology, with published work also spanning several related subfields.

The main subfields of study for Testa include pulmonary and respiratory medicine, molecular biology, cancer research, oncology, and hematology. Their research topics reflect these areas, covering subjects such as occupational and environmental lung diseases, medical imaging and pathology studies, DNA repair mechanisms, pleural and pulmonary diseases, renal cell carcinoma treatment, carcinogens and genotoxicity assessment, as well as interstitial lung diseases and idiopathic pulmonary fibrosis.

Testa has contributed to several frequent publication venues, including Cancer Genetics, Cancers, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, and Molecular Cell. They often collaborate with a consistent group of co-authors, among whom are Eleonora Sementino, Yuwaraj Kadariya, Jianming Pei, Mitchell Cheung, and Kathy Q. Cai.

Recent papers attributable to Testa include the following:

  • The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells, 2022, Science Signaling
  • Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma, 2020, Clinical Cancer Research
  • BRCA1 Mutational Complementation Induces Synthetic Viability, 2020, Molecular Cell
  • DLX Genes: Roles in Development and Cancer, 2021, Cancers
  • Asbestos and Other Hazardous Fibrous Minerals: Potential Exposure Pathways and Associated Health Risks, 2022, International Journal of Environmental Research and Public Health

Joseph R. Testa has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS), receiving this distinction in 2011.

Best Publications

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

  • Perturbations of the AKT signaling pathway in human cancer

    Deborah A Altomare;Joseph R Testa

  • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

    A Bellacosa;Testa;SP Staal;PN Tsichlis

  • AKT plays a central role in tumorigenesis.

    Joseph R. Testa;Alfonso Bellacosa

  • Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.

    A. Bellacosa;D. De Feo;A. K. Godwin;D. W. Bell

  • Germline BAP1 mutations predispose to malignant mesothelioma

    Joseph R Testa;Mitchell Cheung;Jianming Pei;Jennifer E Below

  • Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

    Jin Quan Cheng;Bruce Ruggeri;Walter M. Klein;Gonosuke Sonoda

  • Activation of AKT kinases in cancer: implications for therapeutic targeting.

    Alfonso Bellacosa;C. Chandra Kumar;Antonio Di Cristofano;Joseph Robert Testa

  • AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

    Jin Quan Cheng;Andrew K. Godwin;Alfonso Bellacosa;Takahiro Taguchi

  • BAP1 and cancer

    Michele Carbone;Haining Yang;Harvey I. Pass;Thomas Krausz

  • Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.

    Andrew C. Hsieh;Maria Costa;Ornella Zollo;Cole Davis

  • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways

    Guang-Hui Xiao;Michael Jeffers;Alfonso Bellacosa;Yasuhiro Mitsuuchi

  • AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth

    Deborah A Altomare;Hui Qin Wang;Kristine L Skele;Assunta De Rienzo

  • The pathogenesis of mesothelioma

    Michele Carbone;Robert A. Kratzke;Joseph R. Testa;Joseph R. Testa;Joseph R. Testa

  • Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

    Bruce A. Ruggeri;Lingyi Huang;Moira Wood;Jin Quan Cheng

  • High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas

    Albert B. Bianchi;Shin-Ichiro Mitsunaga;Jin Quan Cheng;Walter M. Klein

  • Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene

    Raymond S. Yeung;Guang-Hui Xiao;Fang Jin;Wen-Ching Lee

  • p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma.

    Jin Quan Cheng;Suresh C. Jhanwar;Walter M. Klein;Daphne W. Bell

  • Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia.

    Charles A. Schiffer;Edward J. Lee;Takafumi Tomiyasu;Peter H. Wiernik

  • Integrated genomic analyses of ovarian carcinoma

    D. Bell;A. Berchuck;M. Birrer;J. Chien

Frequent Co-Authors

Suresh C. Jhanwar
Suresh C. Jhanwar Memorial Sloan Kettering Cancer Center
Michele Carbone
Michele Carbone University of Hawaii at Manoa
Andres J. P. Klein-Szanto
Andres J. P. Klein-Szanto Fox Chase Cancer Center
Robert G. Uzzo
Robert G. Uzzo Fox Chase Cancer Center
Harvey I. Pass
Harvey I. Pass New York University
Alfonso Bellacosa
Alfonso Bellacosa Fox Chase Cancer Center
Jill M. Siegfried
Jill M. Siegfried University of Minnesota
David L. Wiest
David L. Wiest Fox Chase Cancer Center
Thomas C. Hamilton
Thomas C. Hamilton Fox Chase Cancer Center
Nancy A. Jenkins
Nancy A. Jenkins The University of Texas MD Anderson Cancer Center

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