2011 - Fellow of the American Association for the Advancement of Science (AAAS)
His primary scientific interests are in Cancer research, Carcinogenesis, Molecular biology, Protein kinase B and Gene. The concepts of his Cancer research study are interwoven with issues in Immunohistochemistry, Ovarian cancer, Tumor suppressor gene, Cell cycle and PTEN. His Carcinogenesis research integrates issues from Mesothelioma, Pathology, Oncogene and Immunology.
His biological study spans a wide range of topics, including Nucleic acid sequence, Gene expression, Coding region, Subfamily and AKT2. His Protein kinase B study integrates concerns from other disciplines, such as PI3K/AKT/mTOR pathway and Hepatocyte growth factor. Gene is a subfield of Genetics that Joseph R. Testa studies.
His primary areas of investigation include Cancer research, Molecular biology, Genetics, Gene and Carcinogenesis. His research in Cancer research intersects with topics in Cancer, Protein kinase B, Cell culture, Mesothelioma and Cell growth. His Protein kinase B research is multidisciplinary, incorporating elements of PI3K/AKT/mTOR pathway and PTEN.
The study incorporates disciplines such as CDKN2A, Immunology and Carcinogen in addition to Mesothelioma. His Molecular biology research incorporates elements of Gene expression, In situ hybridization, Chromosomal translocation, Complementary DNA and Fluorescence in situ hybridization. He is interested in Tumor suppressor gene, which is a field of Carcinogenesis.
Joseph R. Testa mostly deals with Cancer research, Cancer, BAP1, Mesothelioma and Pathology. His Cancer research study combines topics in areas such as Protein kinase B, Cell growth, Carcinogenesis, Downregulation and upregulation and Lymphoma. His Cancer study introduces a deeper knowledge of Genetics.
Joseph R. Testa studies Genetics, focusing on Gene in particular. His research on Mesothelioma also deals with topics like
Joseph R. Testa mainly focuses on BAP1, Cancer research, Mesothelioma, CDKN2A and Cancer. He interconnects SETD2, Protein kinase B, Cisplatin, Cancer cell and Cancer stem cell in the investigation of issues within Cancer research. His research investigates the connection between Mesothelioma and topics such as Internal medicine that intersect with issues in Surgery and Gastroenterology.
Joseph R. Testa combines subjects such as Inflammasome, Carcinogen, Downregulation and upregulation, Pathology and Stem cell with his study of CDKN2A. His study in Pathology is interdisciplinary in nature, drawing from both Cell, AKT2 and Adenocarcinoma. Particularly relevant to Carcinogenesis is his body of work in Cancer.
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Integrated genomic analyses of ovarian carcinoma
D. Bell;A. Berchuck;M. Birrer;J. Chien.
Perturbations of the AKT signaling pathway in human cancer
Deborah A Altomare;Joseph R Testa.
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
A Bellacosa;Testa;SP Staal;PN Tsichlis.
AKT plays a central role in tumorigenesis.
Joseph R. Testa;Alfonso Bellacosa.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas.
A. Bellacosa;D. De Feo;A. K. Godwin;D. W. Bell.
International Journal of Cancer (1995)
Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
Jin Quan Cheng;Bruce Ruggeri;Walter M. Klein;Gonosuke Sonoda.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Germline BAP1 mutations predispose to malignant mesothelioma
Joseph R Testa;Mitchell Cheung;Jianming Pei;Jennifer E Below.
Nature Genetics (2011)
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
Jin Quan Cheng;Andrew K. Godwin;Alfonso Bellacosa;Takahiro Taguchi.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Activation of AKT kinases in cancer: implications for therapeutic targeting.
Alfonso Bellacosa;C. Chandra Kumar;Antonio Di Cristofano;Joseph Robert Testa.
Advances in Cancer Research (2005)
BAP1 and cancer
Michele Carbone;Haining Yang;Harvey I. Pass;Thomas Krausz.
Nature Reviews Cancer (2013)
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