Okio Hino

Overview

Best Publications

• Autophagy-deficient mice develop multiple liver tumors

  Akito Takamura;Masaaki Komatsu;Taichi Hara;Ayako Sakamoto

  1334
  Citations

• Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.

  Xinsheng Gao;Yong Zhang;Peter Arrazola;Okio Hino

  836
  Citations

• Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

  Yoshihiro Inami;Satoshi Waguri;Ayako N. Sakamoto;Tsuguka Kouno

  758
  Citations

• A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.

  Toshiyuki Kobayashi;Youko Hirayama;Etsuko Kobayashi;Yoshiaki Kubo

  420
  Citations

• Renal Carcinogenesis, Hepatic Hemangiomatosis, and Embryonic Lethality Caused by a Germ-Line Tsc2 Mutation in Mice

  Toshiyuki Kobayashi;Osamu Minowa;Junko Kuno;Hiroaki Mitani

  397
  Citations

• Allelotype study of primary hepatocellular carcinoma.

  M Fujimori;T Tokino;O Hino;T Kitagawa

  374
  Citations

• A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice

  Toshiyuki Kobayashi;Osamu Minowa;Yoshinobu Sugitani;Setsuo Takai

  344
  Citations

• A Mutation in the SDHC Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis

  Takamasa Ishii;Kayo Yasuda;Akira Akatsuka;Okio Hino

  298
  Citations

• Expression and replication of hepatitis B virus genome in transgenic mice

  Kimi Araki;Jun-Ichi Miyazaki;Okio Hino;Naohiro Tomita

  267
  Citations

• Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.

  Atsushi Sato;Shinya Kasai;Toshiyuki Kobayashi;Yukio Takamatsu

  261
  Citations

• Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

  Yutaka Shigeyama;Toshiyuki Kobayashi;Yoshiaki Kido;Naoko Hashimoto

  241
  Citations

• Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer

  Okio Hino;Andres J. P. Klein-Szanto;Jerome J. Freed;Joseph R. Testa

  222
  Citations

• Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1

  Hiroshi Aoki;Junpei Hayashi;Junpei Hayashi;Mitsuhiko Moriyama;Yasuyuki Arakawa

  210
  Citations

• Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation

  Okio Hino;Thomas B. Shows;Charles E. Rogler

  199
  Citations

• Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor α

  Junpei Hayashi;Hiroshi Aoki;Hiroshi Aoki;Kazunori Kajino;Mitsuhiko Moriyama

  197
  Citations

• Clinical and genetic spectrum of Birt–Hogg–Dubé syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature

  Makiko Kunogi;Masatoshi Kurihara;Takako Shigihara Ikegami;Toshiyuki Kobayashi

  188
  Citations

• Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.

  Haruo Tsuchiya;Tokuhiro Iseda;Okio Hino

  182
  Citations

• Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis.

  Teruhiko Sato;Kuniaki Seyama;Hiroaki Fujii;Hiroshi Maruyama

  179
  Citations

• Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.

  Y Takagi;T Kobayashi;M Shiono;L Wang

  146
  Citations

• A germ-line insertion in the Birt–Hogg–Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer

  Kazuo Okimoto;Junko Sakurai;Toshiyuki Kobayashi;Hiroaki Mitani

  136
  Citations