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Molecular Biology

D-Index
50
Citations
9517
World Ranking
2569
National Ranking
1263

Overview

David L. Wiest is a researcher affiliated with Fox Chase Cancer Center in the United States. Their work spans multiple domains within immunology and medicine, with a significant focus on immune cell function, T-cell and B-cell immunology, and cancer research.

The scientist's research contributions cover primary fields of immunology and microbiology, as well as medicine. More specific subfields explored include immunology, oncology, molecular biology, genetics, and cancer research. The main topics addressed in their publications involve immune cell function and interaction, T-cell and B-cell immunology, CAR-T cell therapy research, immunotherapy and immune responses, interferon and immune responses, immunodeficiency and autoimmune disorders, and the diagnosis and treatment of myeloproliferative neoplasms.

David L. Wiest has authored several recent papers, including:

  • NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma, 2020, published in Cell Reports
  • IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma, 2022, published in Cancer Discovery
  • The E protein-TCF1 axis controls γδ T cell development and effector fate, 2021, published in Cell Reports
  • Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo, 2021, published in Cell Reports
  • Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes, 2022, published in Nature Communications

They frequently collaborate with other researchers, with notable co-authors including Alejandra Contreras, Susan A. Shinton, Esteban Martínez, Shawn P. Fahl, and Billy Truong.

The majority of David L. Wiest's publications have appeared in several prominent venues, such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Reports
  • Frontiers in Immunology

Best Publications

  • Functional genomic landscape of acute myeloid leukaemia

    Jeffrey W. Tyner;Cristina E. Tognon;Cristina E. Tognon;Daniel Bottomly;Beth Wilmot

  • On the dynamics of TCR:CD3 complex cell surface expression and downmodulation.

    Haiyan Liu;Michele Rhodes;David L Wiest;Dario A.A Vignali;Dario A.A Vignali

  • Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation

    Maria Ciofani;Gisèle C. Knowles;David L. Wiest;Harald von Boehmer

  • Non-coding transcription instructs chromatin folding and compartmentalization to dictate enhancer-promoter communication and t cell fate

    Takeshi Isoda;Amanda J. Moore;Zhaoren He;Vivek Chandra

  • Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

    Mariëlle C. Haks;Juliette M. Lefebvre;Jens Peter H. Lauritsen;Michael Carleton

  • Activation-induced ubiquitination of the T cell antigen receptor

    Cristina Cenciarelli;Damon Hou;Kou-Ching Hsu;Barbara L. Rellahan

  • Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately.

    David L. Wiest;Janis K. Burkhardt;Susan Hester;Michael Hortsch

  • Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

    Stephen J. Anderson;Jens Peter Holst Lauritsen;Matthew G. Hartman;Ann Marie DiGeorge Foushee

  • The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

    Yifan Wang;Andrea J. Bernhardy;Cristina Cruz;John J. Krais

  • Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

    Shou Yamasaki;Eri Ishikawa;Machie Sakuma;Koji Ogata

  • Marked Induction of the Helix-Loop-Helix Protein Id3 Promotes the γδ T Cell Fate and Renders Their Functional Maturation Notch Independent

    Jens Peter Holst Lauritsen;Gladys W. Wong;Gladys W. Wong;Sang-Yun Lee;Juliette M. Lefebvre

  • Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

    Shuyun Rao;Sang-Yun Lee;Alejandro Gutierrez;Jacqueline Perrigoue

  • Branching out to gain control: how the pre-TCR is linked to multiple functions

    Ada M Kruisbeek;Mariëlle C Haks;Michael Carleton;David L Wiest

  • A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre–B Receptor Assembly

    R. Wasserman;Y.-S. Li;S.A. Shinton;C.E. Carmack

  • Regulation of lineage commitment distinct from positive selection.

    Robert Keefe;Vibhuti Dave;David Allman;David Wiest

  • Early Growth Response Transcription Factors Are Required for Development of CD4−CD8− Thymocytes to the CD4+CD8+ Stage

    Michael Carleton;Mariëlle C. Haks;Mariëlle C. Haks;Sigrid A. A. Smeele;Allan Jones

  • The Ribosomal Protein Rpl22 Controls Ribosome Composition by Directly Repressing Expression of Its Own Paralog, Rpl22l1

    Monique N. O'Leary;Katherine H. Schreiber;Katherine H. Schreiber;Yong Zhang;Anne Cécile E. Duc

  • Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

    Amos J. Simon;Atar Lev;Yong Zhang;Batia Weiss

  • Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition.

    Changchuin Mao;Esmerina G. Tili;Marei Dose;Mariëlle C. Haks

  • Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B

    Divya Punwani;Yong Zhang;Jason Yu;Morton J. Cowan

Frequent Co-Authors

Juan Carlos Zúñiga-Pflücker
Juan Carlos Zúñiga-Pflücker University of Toronto
Joseph R. Testa
Joseph R. Testa Fox Chase Cancer Center
Roland L. Dunbrack
Roland L. Dunbrack Fox Chase Cancer Center
Dario A. A. Vignali
Dario A. A. Vignali University of Pittsburgh
Gerard P. Zambetti
Gerard P. Zambetti St. Jude Children's Research Hospital
Richard R. Hardy
Richard R. Hardy Fox Chase Cancer Center
Amit Verma
Amit Verma Albert Einstein College of Medicine
Rugang Zhang
Rugang Zhang The Wistar Institute
Rebecca H. Buckley
Rebecca H. Buckley Duke University
Brian K. Kennedy
Brian K. Kennedy National University of Singapore

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