His scientific interests lie mostly in Genetics, Immunogenetics, Gene, Haplotype and Immunology. His studies in Allele, Locus, Genome, Antibody and Linkage disequilibrium are all subfields of Genetics research. He interconnects Major histocompatibility complex, Major histocompatibility, Genome database and Immunoglobulin superfamily in the investigation of issues within Immunogenetics.
The Immunoglobulin superfamily study combines topics in areas such as Proteome, Sequence analysis, Complementarity determining region, T-cell receptor and Computational biology. His studies deal with areas such as Evolutionary biology, Genetic variation and Phylogenetic tree as well as Haplotype. His Immunology research includes themes of Hematopoietic stem cell transplantation and Mendelian inheritance.
Gérard Lefranc mostly deals with Genetics, Gene, Molecular biology, Allele and Immunology. His study in Restriction fragment length polymorphism, Haplotype, Locus, Allele frequency and Gene mapping are all subfields of Genetics. His research investigates the link between Haplotype and topics such as Genetic variation that cross with problems in Evolutionary biology and Genetic diversity.
His Gene research incorporates themes from Antibody, Computational biology and Identification. His Molecular biology study integrates concerns from other disciplines, such as DNA, Molecular probe, Immunoglobulin heavy chain, Pseudogene and Immunoglobulin E. His study focuses on the intersection of Allele and fields such as Internal medicine with connections in the field of Dermatology.
Immunology, Genetics, Gene, DOCK8 Deficiency and Genotype are his primary areas of study. His study looks at the relationship between Immunology and topics such as Severe combined immunodeficiency, which overlap with RAG2, Hyper IgM syndrome, Treatment outcome and Lymphocyte proliferation. Genetics is represented through his Haplotype, DNMT3B, DNA methylation, Consanguinity and Major histocompatibility research.
In Haplotype, Gérard Lefranc works on issues like Locus, which are connected to Rheumatoid arthritis, Linkage disequilibrium and Haploview. His study looks at the intersection of Gene and topics like Antibody with Human genome and T-cell receptor. His work focuses on many connections between Genotype and other disciplines, such as Gastroenterology, that overlap with his field of interest in Internal medicine, Body mass index, Case-control study and Genetic marker.
Gérard Lefranc mainly investigates Immunology, Genetics, DOCK8 Deficiency, Immunodeficiency and Immunophenotyping. His Immunology research incorporates elements of Severe combined immunodeficiency, RAG2 and Hyper IgM syndrome. His Gene, DNMT3B, DNA methylation, Immunogenetics and Major histocompatibility study are his primary interests in Genetics.
As a member of one scientific family, he mostly works in the field of DNMT3B, focusing on DNA hypomethylation and, on occasion, Molecular biology. The concepts of his DOCK8 Deficiency study are interwoven with issues in Hematopoietic stem cell transplantation, Hypereosinophilia and FOXP3. His Immunodeficiency research is multidisciplinary, incorporating elements of Founder effect and Dermatophyte.
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IMGT unique numbering for immunoglobulin and T cell receptor variable domains and Ig superfamily V-like domains.
Marie-Paule Lefranc;Christelle Pommié;Quentin Kaas;Elodie Duprat.
Developmental and Comparative Immunology (2003)
IMGT®, the international ImMunoGeneTics information system®
Marie-Paule Lefranc;Véronique Giudicelli;Chantal Ginestoux;Joumana Jabado-Michaloud.
Nucleic Acids Research (2004)
Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance
Sarah A. Tishkoff;Robert Varkonyi;Nelie Cahinhinan;Salem Abbes.
IMGT®, the international ImMunoGeneTics information system® 25 years on
Marie-Paule Lefranc;Véronique Giudicelli;Patrice Duroux;Joumana Jabado-Michaloud.
Nucleic Acids Research (2015)
The Immunoglobulin FactsBook
Marie-Paule Lefranc;Gérard Lefranc.
Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A
S. Baghdiguian;M. Martin;I. Richard;F. Pons.
Nature Medicine (1999)
Deep dermatophytosis and inherited CARD9 deficiency.
Fanny Lanternier;Saad Pathan;Quentin B. Vincent;Luyan Liu.
The New England Journal of Medicine (2013)
IMGT standardized criteria for statistical analysis of immunoglobulin V-REGION amino acid properties.
Christelle Pommié;Séverine Levadoux;Robert Sabatier;Gérard Lefranc.
Journal of Molecular Recognition (2004)
Loss of Calpain 3 Proteolytic Activity Leads to Muscular Dystrophy and to Apoptosis-Associated Iκbα/Nuclear Factor κb Pathway Perturbation in Mice
Isabelle Richard;Carinne Roudaut;Sylvie Marchand;Stephen Baghdiguian.
Journal of Cell Biology (2000)
The T cell receptor factsbook
Marie-Paule Lefranc;Gérard Lefranc.
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