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Immunology
Turkey
2026

D-Index & Metrics

Immunology

D-Index
43
Citations
10143
World Ranking
4820
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Immunology in Turkey Leader Award

Overview

Sevgi Keles is affiliated with Necmettin Erbakan University in Turkey, with a research focus primarily in immunology and related biomedical sciences. Their work spans several interrelated fields including Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these domains, they have contributed extensively to subfields such as Immunology, Genetics, Infectious Diseases, Epidemiology, and Molecular Biology.

Their research covers a range of topics which include Immunodeficiency and Autoimmune Disorders, Blood disorders and treatments, Immune Cell Function and Interaction, T-cell and B-cell Immunology, SARS-CoV-2 and COVID-19 Research, Diabetes and associated disorders, and COVID-19 Clinical Research Studies.

Sevgi Keles has frequently published in notable venues, reflecting a sustained engagement with high-impact platforms. These publication venues include:

  • The Journal of Experimental Medicine
  • Journal of Clinical Immunology
  • Science Immunology
  • Research Square (Research Square)
  • Frontiers in Immunology

Several recent papers demonstrate their involvement in COVID-19 and immunology research, with works published in Science, Science Immunology, and Proceedings of the National Academy of Sciences. These notable papers include:

  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 (2020, Science)
  • Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths (2021, Science Immunology)
  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 (2021, Science Immunology)
  • The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies (2022, Proceedings of the National Academy of Sciences)
  • Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children (2022, Science)

In collaboration, Keles has frequently co-authored with several researchers, including İsmail Reisli, Şükrü Nail Güner, Mehmet Ali Karaselek, Paul Bastard, and Tayfun Özçelık, reflecting a network of contributors working on related immunological and clinical subjects.

Best Publications

  • Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

    Qian Zhang;Paul Bastard;Paul Bastard;Zhiyong Liu;Jérémie Le Pen

  • Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

    Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  • Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

    Karin R. Engelhardt;Sean McGhee;Sabine Winkler;Atfa Sassi

  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

    Takaki Asano;Bertrand Boisson;Bertrand Boisson;Bertrand Boisson;Fanny Onodi;Daniela Matuozzo;Daniela Matuozzo

  • DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients

    Susanne E. Aydin;Sara Sebnem Kilic;Caner Aytekin;Ashish Kumar

  • Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA

    Louis-Marie Charbonnier;Erin Janssen;Janet Chou;Toshiro K. Ohsumi

  • Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized controlled trial

    A. O. Eifan;T. Akkoc;A. Yildiz;S. Keles

  • The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

    Unknown

  • DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

    Haifa H. Jabara;Douglas R. McDonald;Erin Janssen;Michel J. Massaad

  • The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency.

    Karin R. Engelhardt;Karin R. Engelhardt;Karin R. Engelhardt;Michael E. Gertz;Sevgi Keles;Sevgi Keles;Alejandro A. Schäffer

  • Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

    Unknown

  • A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

    Vivien Béziat;Vivien Béziat;Juan Li;Jian-Xin Lin;Cindy S. Ma;Cindy S. Ma

  • Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

    Kerry Dobbs;Cecilia Domínguez Conde;Shen-Ying Zhang;Silvia Parolini

  • Anaphylaxis to multiple pollen allergen sublingual immunotherapy

    A. O. Eifan;S. Keles;N. N. Bahceciler;I. B. Barlan

  • DOCK8 deficiency: Insights into pathophysiology, clinical features and management

    Catherine M. Biggs;Sevgi Keles;Talal A. Chatila

  • Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score

    Victoria Katharina Tesch;Hassan Abolhassani;Hassan Abolhassani;Bella Shadur;Bella Shadur;Joachim Zobel

  • Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency.

    Ayca Kiykim;Ismail Ogulur;Esra Dursun;Louis Marie Charbonnier

  • A novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes.

    Sevgi Keles;Elif Karakoc-Aydiner;Ahmet Ozen;Ayse Gul Izgi

  • SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

    Vanessa Sancho-Shimizu;Petter Brodin;Aurélie Cobat;Aurélie Cobat;Aurélie Cobat;Catherine M Biggs

  • Defects along the TH17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome

    Shadi Al Khatib;Sevgi Keles;Maria Garcia-Lloret;Elif Karakoc-Aydiner

  • Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation

    Fayhan J. Alroqi;Louis-Marie Charbonnier;Safa Baris;Ayca Kiykim

  • Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.

    Erin Janssen;Erin Janssen;Henner Morbach;Sumana Ullas;Jason M. Bannock

Frequent Co-Authors

Talal A. Chatila
Talal A. Chatila Boston Children's Hospital
Raif S. Geha
Raif S. Geha Boston Children's Hospital
Bodo Grimbacher
Bodo Grimbacher University of Freiburg
Waleed Al-Herz
Waleed Al-Herz Kuwait University
Andrew R. Gennery
Andrew R. Gennery Newcastle University
Bertrand Boisson
Bertrand Boisson Rockefeller University
Necil Kutukculer
Necil Kutukculer Ege University
Sung-Yun Pai
Sung-Yun Pai National Institutes of Health
Janet Chou
Janet Chou Boston Children's Hospital
Laurent Abel
Laurent Abel Université Paris Cité

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