World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
80
Citations
23343
World Ranking
1625
National Ranking
809

Overview

Alexandra F. Freeman is affiliated with the National Institute of Allergy and Infectious Diseases in the United States. Their research spans multiple areas within medicine and immunology, with a particular focus on immunodeficiency and autoimmune disorders, immune cell function and interaction, and blood disorders and treatments. Additional topics in their work include fungal infections and studies, T-cell and B-cell immunology, antifungal resistance and susceptibility, and cytomegalovirus and herpesvirus research.

Freeman's research output includes notable papers published in high-impact journals. Selected recent papers include: Coronavirus disease 2019 in patients with inborn errors of immunity: An international study (2020, Journal of Allergy and Clinical Immunology); Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report (2020, Nature Medicine); Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells (2021, Nature Immunology); STAT3 Hyper-IgE Syndrome-an Update and Unanswered Questions (2021, Journal of Clinical Immunology); Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations (2020, Journal of Allergy and Clinical Immunology).

The scientist has collaborated frequently with several coauthors, including Steven M. Holland, Jenna Bergerson, Michail S. Lionakis, Luigi D. Notarangelo, and Amanda Urban.

Freeman's publications are primarily featured in the following venues:

  • Journal of Allergy and Clinical Immunology
  • Journal of Clinical Immunology
  • Clinical Immunology
  • The Journal of Allergy and Clinical Immunology In Practice
  • Journal of Human Immunity

Their main fields of study include medicine and immunology and microbiology. Subfields of focus are immunology, genetics, infectious diseases, epidemiology, and pulmonary and respiratory medicine.

Best Publications

  • Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

    Joshua D. Milner;Jason M. Brenchley;Jason M. Brenchley;Arian Laurence;Alexandra F. Freeman

  • STAT3 Mutations in the Hyper-IgE Syndrome

    Steven M. Holland;Frank R. DeLeo;Houda Z. Elloumi;Amy P. Hsu

  • Combined Immunodeficiency Associated with DOCK8 Mutations

    Qian Zhang;Jeremiah C. Davis;Ian T. Lamborn;Alexandra F. Freeman

  • GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity

    Michael A. Spinner;Lauren A. Sanchez;Amy P. Hsu;Pamela A. Shaw

  • Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

    Sebastian Köhler;Leigh Carmody;Nicole A. Vasilevsky;Julius O. B. Jacobsen

  • Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

    Amy P. Hsu;Elizabeth P. Sampaio;Javed Khan;Katherine R. Calvo

  • Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

    Michael J. Ombrello;Elaine F. Remmers;Guangping Sun;Alexandra F. Freeman

  • Common Severe Infections in Chronic Granulomatous Disease

    Beatriz E. Marciano;Christine Spalding;Alan Fitzgerald;Daphne Mann

  • Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

    Donald C. Vinh;Smita Y. Patel;Gulbu Uzel;Victoria L. Anderson

  • Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

    Cristina Woellner;E. Michael Gertz;Alejandro A. Schäffer;Macarena Lagos

  • Coronavirus Disease 2019 in patients with inborn errors of immunity: an international study.

    Isabelle Meyts;Giorgia Bucciol;Isabella Quinti;Bénédicte Neven

  • The altered landscape of the human skin microbiome in patients with primary immunodeficiencies

    Julia Oh;Alexandra F. Freeman;Nisc Comparative Sequencing Program;Morgan Park

  • A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans.

    Nicolas Dutzan;Nicolas Dutzan;Tetsuhiro Kajikawa;Loreto Abusleme;Loreto Abusleme;Teresa Greenwell-Wild

  • A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory

    Andrea M. Siegel;Jennifer Heimall;Alexandra F. Freeman;Amy P. Hsu

  • Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.

    Gulbu Uzel;Elizabeth P. Sampaio;Monica G. Lawrence;Amy P. Hsu

  • DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients

    Susanne E. Aydin;Sara Sebnem Kilic;Caner Aytekin;Ashish Kumar

  • Anti–GM-CSF Autoantibodies in Patients with Cryptococcal Meningitis

    Lindsey B. Rosen;Alexandra F. Freeman;Lauren M. Yang;Lauren M. Yang;Kamonwan Jutivorakool;Kamonwan Jutivorakool

  • The Hyper IgE Syndromes

    Alexandra F. Freeman;Steven M. Holland

  • Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment

    Yu Zhang;Xiaomin Yu;Mie Ichikawa;Jonathan J. Lyons

  • Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.

    Lisa R. Forbes;Tiphanie P. Vogel;Megan A. Cooper;Johana Castro-Wagner

Frequent Co-Authors

Steven M. Holland
Steven M. Holland National Institute of Allergy and Infectious Diseases
Steven M. Holland
Steven M. Holland University of Georgia
Amy P. Hsu
Amy P. Hsu National Institutes of Health
Joshua D. Milner
Joshua D. Milner Columbia University
Helen C. Su
Helen C. Su National Institutes of Health
Gulbu Uzel
Gulbu Uzel National Institute of Allergy and Infectious Diseases
Kenneth N. Olivier
Kenneth N. Olivier National Institutes of Health
Bodo Grimbacher
Bodo Grimbacher University of Freiburg
Jordan S. Orange
Jordan S. Orange University of Pennsylvania
Stuart G. Tangye
Stuart G. Tangye Garvan Institute of Medical Research

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