H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Immunology D-index 54 Citations 12,766 134 World Ranking 2344 National Ranking 1136

Overview

What is she best known for?

The fields of study she is best known for:

  • Internal medicine
  • Immune system
  • Gene

Alexandra F. Freeman mainly focuses on Immunology, Dock8, Immunodeficiency, Job Syndrome and Immunopathology. The study incorporates disciplines such as Mutation, Monocytopenia and Pathology in addition to Immunology. Her study in Dock8 is interdisciplinary in nature, drawing from both Signal transduction, Interleukin 17 and Lymphocyte.

Her Immunodeficiency study integrates concerns from other disciplines, such as Hematopoietic stem cell transplantation, Respiratory tract infections, Cdc42 GTP-Binding Protein, Chemotaxis and Internal medicine. She works mostly in the field of Job Syndrome, limiting it down to topics relating to Connective tissue and, in certain cases, Etiology, Proinflammatory cytokine, Molecular biology, STAT3 GOF and STAT3, as a part of the same area of interest. Her Immunopathology research includes themes of Periodontitis, Cellular differentiation, Homeostasis, Immune tolerance and Rash.

Her most cited work include:

  • Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome (953 citations)
  • STAT3 Mutations in the Hyper-IgE Syndrome (894 citations)
  • Combined Immunodeficiency Associated with DOCK8 Mutations (502 citations)

What are the main themes of her work throughout her whole career to date?

Alexandra F. Freeman mostly deals with Immunology, Internal medicine, Immunoglobulin E, Primary immunodeficiency and Immunodeficiency. Her Immunology study frequently links to related topics such as Disease. Her Internal medicine research includes elements of Gastroenterology, Endocrinology and Cardiology.

Her Immunoglobulin E course of study focuses on STAT3 and Cancer research. Alexandra F. Freeman interconnects Chronic mucocutaneous candidiasis and Connective tissue in the investigation of issues within Primary immunodeficiency. Her Dock8 research is multidisciplinary, relying on both Malignancy and Lymphocyte.

She most often published in these fields:

  • Immunology (57.09%)
  • Internal medicine (16.79%)
  • Immunoglobulin E (15.67%)

What were the highlights of her more recent work (between 2017-2021)?

  • Immunology (57.09%)
  • STAT3 (11.19%)
  • Immune system (9.70%)

In recent papers she was focusing on the following fields of study:

Alexandra F. Freeman mainly investigates Immunology, STAT3, Immune system, Primary immunodeficiency and Immunoglobulin E. Her Immunology research incorporates themes from Hematopoietic stem cell transplantation and Disease. The various areas that Alexandra F. Freeman examines in her STAT3 study include Cancer research and STAT1.

The Immune system study combines topics in areas such as Cell and Signal transduction. As part of the same scientific family, Alexandra F. Freeman usually focuses on Primary immunodeficiency, concentrating on Transplantation and intersecting with Gastroenterology and Immunity. Her work deals with themes such as Medical microbiology and Genetic testing, which intersect with Immunoglobulin E.

Between 2017 and 2021, her most popular works were:

  • Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources. (276 citations)
  • A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans (105 citations)
  • X-linked carriers of chronic granulomatous disease: Illness, lyonization, and stability. (78 citations)

In her most recent research, the most cited papers focused on:

  • Internal medicine
  • Immune system
  • Gene

Her primary scientific interests are in Immunology, Immune system, Immunodeficiency, STAT3 and Immune dysregulation. Her studies in Immunology integrate themes in fields like Loss function, Disease and Staphylococcus aureus. Her research integrates issues of Secretion, Cell signaling, Signal transduction and Inflammatory bowel disease in her study of Immune system.

Her studies deal with areas such as Hematopoietic stem cell transplantation and Internal medicine, Retrospective cohort study as well as Immunodeficiency. She has researched STAT3 in several fields, including Immunoglobulin E and STAT1. As a part of the same scientific study, Alexandra F. Freeman usually deals with the Immune dysregulation, concentrating on Primary immunodeficiency and frequently concerns with Penetrance, Haploinsufficiency, Hypogammaglobulinemia and Common variable immunodeficiency.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Joshua D. Milner;Jason M. Brenchley;Jason M. Brenchley;Arian Laurence;Alexandra F. Freeman.
Nature (2008)

1475 Citations

STAT3 Mutations in the Hyper-IgE Syndrome

Steven M. Holland;Frank R. DeLeo;Houda Z. Elloumi;Amy P. Hsu.
The New England Journal of Medicine (2007)

1164 Citations

Combined Immunodeficiency Associated with DOCK8 Mutations

Qian Zhang;Jeremiah C. Davis;Ian T. Lamborn;Alexandra F. Freeman.
The New England Journal of Medicine (2009)

614 Citations

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

Amy P. Hsu;Elizabeth P. Sampaio;Javed Khan;Katherine R. Calvo.
Blood (2011)

476 Citations

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics and immunity

Michael A. Spinner;Lauren A. Sanchez;Amy P. Hsu;Pamela A. Shaw.
Blood (2014)

440 Citations

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

Michael J. Ombrello;Elaine F. Remmers;Guangping Sun;Alexandra F. Freeman.
The New England Journal of Medicine (2012)

328 Citations

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources.

Sebastian Köhler;Leigh Carmody;Nicole A. Vasilevsky;Julius O. B. Jacobsen.
Nucleic Acids Research (2019)

323 Citations

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

Donald C. Vinh;Smita Y. Patel;Gulbu Uzel;Victoria L. Anderson.
Blood (2010)

300 Citations

A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory

Andrea M. Siegel;Jennifer Heimall;Alexandra F. Freeman;Amy P. Hsu.
Immunity (2011)

300 Citations

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

Cristina Woellner;E. Michael Gertz;Alejandro A. Schäffer;Macarena Lagos.
The Journal of Allergy and Clinical Immunology (2010)

262 Citations

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