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Biology and Biochemistry
Japan
2023

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Takashi Saito is affiliated with Nagoya City University in Japan and has a significant publication record in the fields of Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Their research spans subfields including Physiology, Neurology, Molecular Biology, Cellular and Molecular Neuroscience, and Biological Psychiatry.

Their work focuses on several main topics:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Tryptophan and brain disorders
  • Cholinesterase and Neurodegenerative Diseases
  • Dementia and Cognitive Impairment Research
  • Memory and Neural Mechanisms

Saito has contributed to numerous scientific publications, frequently collaborating with researchers such as Takaomi C. Saido, Hiroki Sasaguri, Naoto Watamura, Shoko Hashimoto, and Naoko Kamano.

Their research articles have appeared in a range of venues. The most frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia
  • Scientific Reports
  • Journal of Alzheimer s Disease
  • Frontiers in Aging Neuroscience

Notable recent papers by Takashi Saito include:

  • "Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease" (2023) in Nature
  • "Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues" (2020) in Nature Communications
  • "Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease" (2021) in Acta Neuropathologica Communications
  • "Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model" (2021) in Molecular Neurodegeneration
  • "Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease" (2020) in Neuron

Best Publications

  • Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

    Koji Atarashi;Takeshi Tanoue;Tatsuichiro Shima;Akemi Imaoka

  • Single App knock-in mouse models of Alzheimer's disease

    Takashi Saito;Yukio Matsuba;Naomi Mihira;Jiro Takano

  • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

    Tadashi Yokosuka;Masako Takamatsu;Wakana Kobayashi-Imanishi;Akiko Hashimoto-Tane

  • Interaction of tyrosine-based sorting signals with clathrin-associated proteins

    Hiroshi Ohno;Jay Stewart;Marie-Christine Fournier;Herbert Bosshart

  • Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization

    Armelle Regnault;Danielle Lankar;Valérie Lacabanne;Ana Rodriguez

  • Design concepts for the Cherenkov Telescope Array CTA: An advanced facility for ground-based high-energy gamma-ray astronomy

    M. Actis;G. Agnetta;F. Aharonian;A. Akhperjanian

  • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

    Rajat Varma;Gabriele Campi;Tadashi Yokosuka;Takashi Saito

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Functional annotation of a full-length mouse cDNA collection

    J. Kawai;A. Shinagawa;K. Shibata;M. Yoshino

  • Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

    Shinobu Saijo;Satoshi Ikeda;Keiko Yamabe;Shigeru Kakuta

  • Introducing the CTA concept

    B. S. Acharya;M. Actis;T. Aghajani;G. Agnetta

  • Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

    Tadashi Yokosuka;Kumiko Sakata-Sogawa;Wakana Kobayashi;Michio Hiroshima

  • APP mouse models for Alzheimer's disease preclinical studies

    Hiroki Sasaguri;Hiroki Sasaguri;Per Nilsson;Per Nilsson;Shoko Hashimoto;Kenichi Nagata

  • Mincle is an ITAM-coupled activating receptor that senses damaged cells.

    Sho Yamasaki;Eri Ishikawa;Machie Sakuma;Hiromitsu Hara

  • Variable very high energy γ-ray emission from markarian 501

    J. Albert;E. Aliu;H. Anderhub;P. Antoranz

  • Very-High-Energy Gamma Rays from a Distant Quasar: How Transparent Is the Universe?

    J Albert;E Aliu;H Anderhub

  • ScaleS: an optical clearing palette for biological imaging

    Hiroshi Hama;Hiroyuki Hioki;Kana Namiki;Tetsushi Hoshida

  • The major upgrade of the MAGIC telescopes, Part II: A performance study using observations of the Crab Nebula

    J. Aleksić;S. Ansoldi;L.A. Antonelli;P. Antoranz

  • Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

    Seung Yong Park;Kaoru Saijo;Takamune Takahashi;Masataka Osawa

  • The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

    A. Poole;J.M. Gibbins;M. Turner;M.J. van Vugt

Frequent Co-Authors

Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Kenji Sugai
Kenji Sugai Tohoku University
Sho Yamasaki
Sho Yamasaki Osaka University
Hisashi Arase
Hisashi Arase Osaka University
Nobuhisa Iwata
Nobuhisa Iwata Nagasaki University
Naoyuki Taniguchi
Naoyuki Taniguchi Osaka University
Shin'ichi Takeda
Shin'ichi Takeda National Center of Neurology and Psychiatry
Haruhiko Koseki
Haruhiko Koseki RIKEN Center for Integrative Medical Sciences

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