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Immunology

D-Index
56
Citations
10846
World Ranking
3729
National Ranking
140

Overview

J. Sjef Verbeek is affiliated with Leiden University Medical Center in the Netherlands and has contributed extensively to research in medicine, particularly focusing on immunology and oncology. Their work intersects multiple disciplines, including radiology, nuclear medicine, molecular biology, and genetics, with a strong emphasis on immunological mechanisms and cancer biology.

Their research mainly revolves around monoclonal and polyclonal antibodies, CAR-T cell therapy, and T-cell and B-cell immunology. Additional areas of focus include glycosylation and glycoproteins, chronic lymphocytic leukemia, immune cell function and interaction, and the role of galectins in cancer biology.

Frequent co-authors collaborating with Verbeek include:

  • Mark S. Cragg
  • Shozo Izui
  • Hreinn Benonisson
  • Conny Brouwers
  • Margot M. Linssen

Their publications appear in various scientific outlets, highlighting contributions to multiple high-impact journals. The frequent venues of publication are:

  • Cancer Cell
  • Clinical & Experimental Immunology
  • Cell Reports
  • Cancers
  • Scientific Reports

Notable recent papers authored or co-authored by Verbeek include:

  • "Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity," 2020, Cancer Cell
  • "Isotype selection for antibody-based cancer therapy," 2020, Clinical & Experimental Immunology
  • "Afucosylated IgG Targets FcγRIV for Enhanced Tumor Therapy in Mice," 2021, Cancers
  • "Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors," 2022, Cell Reports
  • "Immunogenicity of rat-neu+ mouse mammary tumours determines the T cell-dependent therapeutic efficacy of anti-neu monoclonal antibody treatment," 2020, Scientific Reports

Best Publications

  • Arthritis Critically Dependent on Innate Immune System Players

    Hong Ji;Koichiro Ohmura;Koichiro Ohmura;Umar Mahmood;David M Lee

  • Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection

    Matthew J. Robinson;Fabiola Osorio;Marcela Rosas;Rui P. Freitas

  • Impaired IgG-Dependent Anaphylaxis and Arthus Reaction in FcγRIII (CD16) Deficient Mice

    Wouter L.W Hazenbos;J.Engelbert Gessner;Frans M.A Hofhuis;Henri Kuipers

  • Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection

    Stephen A. Beers;Ruth R. French;H. T. Claude Chan;Sean H. Lim

  • FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection.

    A Ioan-Facsinay;S.J de Kimpe;S.M.M Hellwig;P.L van Lent

  • Antigen-Antibody Immune Complexes Empower Dendritic Cells to Efficiently Prime Specific CD8+ CTL Responses In Vivo

    Danita H. Schuurhuis;Andreea Ioan-Facsinay;Bas Nagelkerken;Jolien J. van Schip

  • Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes

    Leendert A. Trouw;Tom W.L. Groeneveld;Marc A. Seelen;Jacques M.G.J. Duijs

  • Interaction with FcγRIIB Is Critical for the Agonistic Activity of Anti-CD40 Monoclonal Antibody

    Ann L. White;H. T. Claude Chan;Ali Roghanian;Ruth R. French

  • Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III.

    Liliane Fossati-Jimack;A. Ioan-Facsinay;Luc Reininger;Yves Chicheportiche

  • Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses.

    Frank A Redegeld;Maurice W van der Heijden;Mirjam Kool;Bianca M Heijdra

  • Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody

    Samareh Azeredo da Silveira;Shuichi Kikuchi;Liliane Fossati-Jimack;Thomas Moll

  • Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling

    Pim J Koelink;Felicia M Bloemendaal;Bofeng Li;Liset Westera

  • Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

    Ann L. White;H.T. Claude Chan;Ruth R. French;Jane E. Willoughby

  • Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18).

    Marjolein van Egmond;A.J. Hanneke van Vuuren;H. Craig Morton;Annemiek B. van Spriel

  • A Codominant Role of FcγRI/III and C5aR in the Reverse Arthus Reaction

    Ulrich Baumann;Jörg Köhl;Thomas Tschernig;Kirsten Schwerter-Strumpf

  • Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

    Nadine van Montfoort;Marcel G. Camps;Selina Khan;Dmitri V. Filippov

  • CD16 promotes Escherichia coli sepsis through an FcR$\gamma$ inhibitory pathway that prevents phagocytosis and facilitates inflammation

    Fabiano Pinheiro da Silva;Fabiano Pinheiro da Silva;Fabiano Pinheiro da Silva;Meryem Aloulou;Meryem Aloulou;David Skurnik;Marc Benhamou;Marc Benhamou

  • C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis

    Jeanne Godau;Tanja Heller;Heiko Hawlisch;Matthew Trappe

  • Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function.

    Sarah L. Buchan;Lang Dou;Marcus Remer;Steven G. Booth

  • Immune Complex-Loaded Dendritic Cells Are Superior to Soluble Immune Complexes as Antitumor Vaccine

    Danita H. Schuurhuis;Nadine van Montfoort;Andreea Ioan-Facsinay;Reshma Jiawan

  • Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.

    Julia Skokowa;Syed R. Ali;Olga Felda;Varsha Kumar

Frequent Co-Authors

Ferry Ossendorp
Ferry Ossendorp Leiden University Medical Center
Shozo Izui
Shozo Izui University of Geneva
Martin J. Glennie
Martin J. Glennie University of Southampton
Mark S. Cragg
Mark S. Cragg University of Southampton
Cornelis J. M. Melief
Cornelis J. M. Melief ISA Pharmaceuticals (Netherlands)
Thorbald van Hall
Thorbald van Hall Leiden University Medical Center
Jeanette H. W. Leusen
Jeanette H. W. Leusen Utrecht University
Falk Nimmerjahn
Falk Nimmerjahn University of Erlangen-Nuremberg
Takashi Saito
Takashi Saito Nagoya City University
Jan G. J. van de Winkel
Jan G. J. van de Winkel Genmab (United States)

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