World's Best Scientists 2026 revealed!

Overview

Lei Yu is affiliated with Rush University Medical Center in the United States, with a research focus centered on medicine, biochemistry, genetics, and molecular biology. Their scholarly contributions cover a range of subfields including psychiatry and mental health, molecular biology, neurology, physiology, and genetics.

The scientist's primary areas of investigation include Alzheimer's disease research and treatments, dementia and cognitive impairment research, neuroinflammation and neurodegeneration mechanisms, genetic associations and epidemiology, Parkinson's disease mechanisms and treatments, bioinformatics and genomic networks, and the role of tryptophan in brain disorders.

Recent notable papers authored or co-authored by Lei Yu highlight their engagement with neurodegenerative disease mechanisms and cognitive aging. These papers include:

  • "Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models," published in 2020 in Cell Reports
  • "Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons," 2020, JAMA Psychiatry
  • "Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline," 2020, JAMA Neurology
  • "Genome-wide analysis of mitochondrial DNA copy number reveals loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation," 2021, Human Genetics
  • "Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy," 2020, Journal of Neuropathology & Experimental Neurology

The venues where Lei Yu frequently publishes reflect a focus on aging, neurological disorders, and molecular pathology. These publication venues include:

  • Alzheimer s & Dementia
  • Neurology
  • The Journals of Gerontology Series A
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica

Collaboration is a significant aspect of Lei Yu's research activity. Frequent co-authors associated with their work are:

  • David A. Bennett
  • Julie A. Schneider
  • Aron S. Buchman
  • Shahram Oveisgharan
  • Philip L. De Jager

Lei Yu's scientific output spans topics that integrate clinical and molecular approaches to neurodegeneration and cognitive health, contributing to ongoing research efforts in understanding complex age-related neurological conditions.

Best Publications

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.

    Peter T. Nelson;Dennis W. Dickson;John Q. Trojanowski;Clifford R. Jack

  • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

    Aysu Okbay;Bart M L Baselmans;Jan-Emmanuel De Neve;Patrick Turley

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

    Cornelius A. Rietveld;Sarah E. Medland;Jaime Lane Derringer;Jian Yang

  • Total daily physical activity and the risk of AD and cognitive decline in older adults

    A.S. Buchman;P.A. Boyle;L. Yu;R.C. Shah

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

    Philip Lawrence De Jager;Gyan Srivastava;Katie Lunnon;Jeremy Burgess

  • Plasma MicroRNA Panel to Diagnose Hepatitis B Virus–Related Hepatocellular Carcinoma

    Jian Zhou;Lei Yu;Xue Gao;Jie Hu

  • Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons.

    Andrew S P Lim;Matthew Kowgier;Lei Yu;Lei Yu;Aron S Buchman;Aron S Buchman

  • Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

    G. Davies;N. Armstrong;J. C. Bis;J. Bressler

  • Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    Eric M Reiman;Joseph F Arboleda-Velasquez;Yakeel T Quiroz;Matthew J Huentelman

  • A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease.

    Sara Mostafavi;Sara Mostafavi;Chris Gaiteri;Sarah E. Sullivan;Charles C. White

  • Person-specific contribution of neuropathologies to cognitive loss in old age

    Patricia A. Boyle;Lei Yu;Robert S. Wilson;Sue E. Leurgans

  • An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome.

    Bernard Ng;Charles C White;Hans-Ulrich Klein;Hans-Ulrich Klein;Solveig K Sieberts

  • Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

    David C. Whitcomb;Jessica LaRusch;Alyssa M. Krasinskas;Lambertus Klei

  • Much of late life cognitive decline is not due to common neurodegenerative pathologies

    Patricia A. Boyle;Robert S. Wilson;Lei Yu;Alasdair M. Barr

  • Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons

    Patricia A. Boyle;Lei Yu;Sukriti Nag;Sue Leurgans

  • Hippocampal sclerosis and TDP‐43 pathology in aging and Alzheimer disease

    Sukriti Nag;Lei Yu;Ana W. Capuano;Robert S. Wilson

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

    Gyan Srivastava;Katie Lunnon;Jeremy Burgess;Lei Yu

  • Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

    Aysu Okbay;Bart M. L. Baselmans;Jan-Emmanuel De Neve;Patrick Turley

Frequent Co-Authors

David A. Bennett
David A. Bennett Rush University Medical Center
Philip L. De Jager
Philip L. De Jager Columbia University
Julie A. Schneider
Julie A. Schneider Rush University Medical Center
Patricia A. Boyle
Patricia A. Boyle Rush University Medical Center
Aron S. Buchman
Aron S. Buchman Rush University Medical Center
Robert S. Wilson
Robert S. Wilson Rush University Medical Center
Konstantinos Arfanakis
Konstantinos Arfanakis Illinois Institute of Technology
Sue Leurgans
Sue Leurgans Rush University Medical Center
Lisa L. Barnes
Lisa L. Barnes Rush University Medical Center
Lori B. Chibnik
Lori B. Chibnik Harvard University

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