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Jeanette H. W. Leusen

Jeanette H. W. Leusen

D-Index & Metrics

Microbiology

D-Index
53
Citations
8448
World Ranking
4133
National Ranking
157

Overview

Jeanette H. W. Leusen is affiliated with Utrecht University in the Netherlands. Their research primarily resides within the intersecting fields of Medicine and Immunology and Microbiology, contributing extensively to the scientific understanding of immune function and therapeutic applications.

The main topics of Leusen's work include:

  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction
  • Immune cells in cancer
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Phagocytosis and Immune Regulation

Leusen's research is disseminated frequently in certain scientific venues, indicating their focus areas and collaborative networks. The publication venues where they most often publish include:

  • Frontiers in Immunology
  • Journal for ImmunoTherapy of Cancer
  • Cancer Immunology Immunotherapy
  • mAbs
  • bioRxiv (Cold Spring Harbor Laboratory)

Their notable recent papers include:

  • "γ9δ2T cell diversity and the receptor interface with tumor cells" (2020), published in Journal of Clinical Investigation
  • "Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents" (2020), published in Antibodies
  • "The Role of Cytokines in Neutrophil Development, Tissue Homing, Function and Plasticity in Health and Disease" (2023), published in Cells
  • "Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRnin vitroandin vivo" (2021), published in mAbs
  • "Complement receptor 3 mediates both sinking phagocytosis and phagocytic cup formation via distinct mechanisms" (2021), published in Journal of Biological Chemistry

Leusen has collaborated regularly with several researchers, indicating active and frequent partnerships. Their frequent co-authors include:

  • Thomas Valerius (18 collaborations)
  • Chilam Chan (15 collaborations)
  • Maaike Nederend (14 collaborations)
  • J.H. Marco Jansen (13 collaborations)
  • Mitchell Evers (10 collaborations)

Their work extends across subfields of Immunology such as Radiology, Nuclear Medicine and Imaging, Oncology, Molecular Biology, and Genetics. This interdisciplinary scope demonstrates a broad engagement with related biomedical sciences to understand immune mechanisms and therapeutic innovations.

Best Publications

  • Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis.

    Hanke L Matlung;Liane Babes;Xi Wen Zhao;Michel van Houdt

  • Mechanisms of action of CD20 antibodies

    Peter Boross;Jeanette H W Leusen

  • The Therapeutic CD38 Monoclonal Antibody Daratumumab Induces Programmed Cell Death via Fcγ Receptor–Mediated Cross-Linking

    Marije B Overdijk;J H Marco Jansen;Maaike Nederend;Jeroen J Lammerts van Bueren

  • Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab.

    Josée Golay;Fabio Da Roit;Luca Bologna;Claudia Ferrara

  • Crosstalk between Human IgG Isotypes and Murine Effector Cells

    Marije B. Overdijk;Sandra Verploegen;Antonio Ortiz Buijsse;Tom Vink

  • Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation.

    Annemiek B. van Spriel;Annemiek B. van Spriel;Jeanette H. W. Leusen;Jeanette H. W. Leusen;Marjolein van Egmond;Marjolein van Egmond;Henry B. P. M. Dijkman;Henry B. P. M. Dijkman

  • Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

    Meike E. W. Logtenberg;J. H. Marco Jansen;Matthijs Raaben;Mireille Toebes

  • Functional Characteristics of the High Affinity IgG Receptor, FcγRI

    Cees E. van der Poel;Robbert M. Spaapen;Jan G. J. van de Winkel;Jan G. J. van de Winkel;Jeanette H. W. Leusen

  • Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection.

    Laurien H. Ulfman;Jeanette H. W. Leusen;Huub F. J. Savelkoul;John O. Warner

  • Interactions between the components of the human NADPH oxidase: intrigues in the phox family.

    Jeanette H.W. Leusen;Jeanette H.W. Leusen;Arthur J. Verhoeven;Arthur J. Verhoeven;Dirk Roos;Dirk Roos

  • Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG.

    Arianne M. Brandsma;Sina Bondza;Mitchell Evers;Rosanne Koutstaal

  • In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

    Simone de Haij;J H Marco Jansen;Peter Boross;Frank J Beurskens

  • Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread

    Christian Büll;Thomas Jan Boltje;Eric A W van Dinther;Timo Peters

  • The High-Affinity IgG Receptor, FcγRI, Plays a Central Role in Antibody Therapy of Experimental Melanoma

    Lisette Bevaart;Marco J.H. Jansen;Martine J. van Vugt;J. Sjef Verbeek

  • IgA EGFR antibodies mediate tumour killing in vivo

    Peter Boross;Stefan Lohse;Maaike Nederend;Johannes Hendrik Marco Jansen

  • A point mutation in gp91-phox of cytochrome b558 of the human NADPH oxidase leading to defective translocation of the cytosolic proteins p47-phox and p67-phox.

    J. H. W. Leusen;M. De Boer;B. J. M. Bolscher;P. M. Hilarius

  • 156Pro-->Gln substitution in the light chain of cytochrome b558 of the human NADPH oxidase (p22-phox) leads to defective translocation of the cytosolic proteins p47-phox and p67-phox.

    Jeanette H. W. Leusen;Ben G. J. M. Bolscher;Petra M. Hilarius;Ron S. Weening

  • Prevalence, genetics and clinical presentation of chronic granulomatous disease in Sweden

    A. Ahlin;M. De Boer;D. Roos;J. Leusen

  • The Importance of Human FcγRI in Mediating Protection to Malaria

    Richard S McIntosh;Jianguo Shi;Richard M Jennings;Jonathan C Chappel;Jonathan C Chappel

  • CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping.

    Anne E Bras;Valerie de Haas;Arthur van Stigt;Mojca Jongen-Lavrencic

  • Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer

    Saskia Meyer;Jeanette H W Leusen;Peter Boross

Frequent Co-Authors

Jan G. J. van de Winkel
Jan G. J. van de Winkel Genmab (United States)
Thomas Valerius
Thomas Valerius Kiel University
Matthias Peipp
Matthias Peipp Kiel University
Gestur Vidarsson
Gestur Vidarsson University of Amsterdam
Falk Nimmerjahn
Falk Nimmerjahn University of Erlangen-Nuremberg
Paul W. H. I. Parren
Paul W. H. I. Parren Leiden University Medical Center
Arthur J. Verhoeven
Arthur J. Verhoeven University of Amsterdam
Dirk Roos
Dirk Roos University of Amsterdam
Marjolein van Egmond
Marjolein van Egmond VU University Medical Center
Anne Krug
Anne Krug Ludwig-Maximilians-Universität München

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