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Shuji Akai

Shuji Akai

D-Index & Metrics

Chemistry

D-Index
44
Citations
6393
World Ranking
16945
National Ranking
1336

Overview

Shuji Akai is affiliated with Osaka University in Japan and has contributed significantly to the field of chemistry, particularly in organic chemistry and biochemistry. Their research spans a wide range of subfields, including organic chemistry, molecular biology, materials chemistry, pharmaceutical science, and spectroscopy.

The main areas of study in Akai's work encompass enzyme catalysis and immobilization, chemical reactions and isotopes, crystallization and solubility studies, X-ray diffraction in crystallography, catalytic C-H functionalization methods, axial and atropisomeric chirality synthesis, and chemical synthesis and analysis.

Akai's recent publications include:

  • Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki-Miyaura Coupling Conditions (2022, Organic Letters)
  • Cobalt-Catalyzed Intermolecular Markovnikov Hydroamination of Nonactivated Olefins: N2-Selective Alkylation of Benzotriazole (2020, Organic Letters)
  • Coupling Reaction between Aldehydes and Non-Activated Hydrocarbons via the Reductive Radical-Polar Crossover Pathway (2020, Organic Letters)
  • Dynamic kinetic resolution of a tertiary alcohol (2020, Chemical Communications)
  • Could London Dispersion Force Control Regioselective (2 + 2) Cyclodimerizations of Benzynes? YES: Application to the Synthesis of Helical Biphenylenes (2021, Journal of the American Chemical Society)

Frequent co-authors who have collaborated extensively with Akai include:

  • Kyohei Kanomata, with 26 joint publications
  • Yoshinari Sawama, with 25 joint publications
  • Takashi Ikawa, with 24 joint publications
  • Kenzo Yahata, with 18 joint publications
  • Hironao Sajiki, with 14 joint publications

Among the venues where Akai has frequently published are:

  • The Cambridge Structural Database, with 12 publications
  • Chemical and Pharmaceutical Bulletin, with 8 publications
  • European Journal of Organic Chemistry, with 7 publications
  • Chemistry - A European Journal, with 6 publications
  • Synlett, with 5 publications

Akai's contributions integrate chemical synthesis techniques with advanced analytical methods such as X-ray crystallography and spectroscopy, reflecting an interdisciplinary approach within chemistry and molecular biology. Their work demonstrates a balance between fundamental chemical research and applications in pharmaceutical sciences and materials chemistry.

Best Publications

  • Cationic Gold(I)-Mediated Intramolecular Cyclization of 3-Alkyne-1,2-diols and 1-Amino-3-alkyn-2-ols: A Practical Route to Furans and Pyrroles

    Masahiro Egi;Kenji Azechi;Shuji Akai

  • Mo-Au combo catalysis for rapid 1,3-rearrangement of propargyl alcohols into alpha,beta-unsaturated carbonyl compounds.

    Masahiro Egi;Yoshiko Yamaguchi;Noboru Fujiwara;Shuji Akai

  • A dynamic kinetic resolution of allyl alcohols by the combined use of lipases and [VO(OSiPh3)3]

    Shuji Akai;Kouichi Tanimoto;Yukiko Kanao;Masahiro Egi

  • Recent Advances in Pummerer Reactions

    Shuji Akai;Yasuyuki Kita

  • A Mesoporous‐Silica‐Immobilized Oxovanadium Cocatalyst for the Lipase‐Catalyzed Dynamic Kinetic Resolution of Racemic Alcohols

    Masahiro Egi;Koji Sugiyama;Moriaki Saneto;Ryosuke Hanada

  • Facile and efficient syntheses of carboxylic anhydrides and amides using (trimethylsilyl)ethoxyacetylene

    Yasuyuki Kita;Shuji Akai;Naomi Ajimura;Mayumi Yoshigi

  • One-pot synthesis of optically active allyl esters via lipase-vanadium combo catalysis.

    Shuji Akai;Ryosuke Hanada;Noboru Fujiwara;Yasuyuki Kita

  • MPP+ induces necrostatin-1- and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells

    Keisuke Ito;Yutaka Eguchi;Yusuke Imagawa;Shuji Akai

  • Synthesis of Biaryl Compounds through Three‐Component Assembly: Ambidentate Effect of the tert‐Butyldimethylsilyl Group for Regioselective Diels–Alder and Hiyama Coupling Reactions

    Shuji Akai;Takashi Ikawa;Sho-ichi Takayanagi;Yuki Morikawa

  • Preparation of Novel Cyclic Hypervalent Idoine(III) Compounds Having Azido, Cyano, and Nitrato Ligands

    S. Akai;T. Okuno;M. Egi;T. Takada

  • Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki-Miyaura Coupling Conditions.

    Unknown

  • Lipase-catalyzed domino dynamic kinetic resolution of racemic 3-vinylcyclohex-2-en-1-ols/intramolecular Diels-Alder reaction: one-pot synthesis of optically active polysubstituted decalins.

    Shuji Akai;Kouichi Tanimoto;Yasuyuki Kita

  • Total Synthesis of (±)-γ-Rubromycin on the Basis of Two Aromatic Pummerer-Type Reactions†

    Shuji Akai;Shuji Akai;Keisuke Kakiguchi;Yuka Nakamura;Ikumi Kuriwaki

  • Highly Regioselective Nucleophilic Carbon−Carbon Bond Formation on Furans and Thiophenes Initiated by Pummerer-Type Reaction

    Shuji Akai;Norihito Kawashita;Hideharu Satoh;Yasufumi Wada

  • Cationic Gold(I)-Catalyzed Intramolecular Cyclization of γ-Hydroxyalkynones into 3(2H)-Furanones

    Masahiro Egi;Kenji Azechi;Moriaki Saneto;Kaori Shimizu

  • ortho‐Selective Nucleophilic Addition of Primary Amines to Silylbenzynes: Synthesis of 2‐Silylanilines

    Takashi Ikawa;Tsuyoshi Nishiyama;Takashi Shigeta;Shinya Mohri

  • Regiocomplementary cycloaddition reactions of boryl- and silylbenzynes with 1,3-dipoles: selective synthesis of benzo-fused azole derivatives.

    Takashi Ikawa;Akira Takagi;Masahiko Goto;Yuya Aoyama

  • Preparation and Regioselective Diels–Alder Reactions of Borylbenzynes: Synthesis of Functionalized Arylboronates

    Takashi Ikawa;Akira Takagi;Yurio Kurita;Kozumo Saito

  • Lipase-Catalyzed Dynamic Kinetic Resolution of C 1 - and C 2 -Symmetric Racemic Axially Chiral 2,2'-Dihydroxy-1,1'-biaryls.

    Gamal A. I. Moustafa;Gamal A. I. Moustafa;Yasuhiro Oki;Shuji Akai

  • Synthesis of various kinds of isoflavones, isoflavanes, and biphenyl-ketones and their 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activities.

    Hideyuki Goto;Yoshiyasu Terao;Shuji Akai

  • A Domino Process for Benzyne Preparation: Dual Activation of o-(Trimethylsilyl)phenols by Nonafluorobutanesulfonyl Fluoride

    Takashi Ikawa;Tsuyoshi Nishiyama;Toshifumi Nosaki;Akira Takagi

  • Mo—Au Combo Catalysis for Rapid 1,3‐Rearrangement of Propargyl Alcohols into α,β‐Unsaturated Carbonyl Compounds.

    Masahiro Egi;Yoshiko Yamaguchi;Noboru Fujiwara;Shuji Akai

Frequent Co-Authors

Yasuyuki Kita
Yasuyuki Kita Ritsumeikan University
Yoshifumi Takeda
Yoshifumi Takeda Okayama University
Hiroshi Maeda
Hiroshi Maeda Kumamoto University
Naoto Oku
Naoto Oku University of Shizuoka
Hideo Tsukada
Hideo Tsukada Hamamatsu Photonics (Japan)
Yoshitaka Hamashima
Yoshitaka Hamashima University of Shizuoka
Toshifumi Dohi
Toshifumi Dohi Ritsumeikan University
Harald Gröger
Harald Gröger Bielefeld University
Yoshihide Tsujimoto
Yoshihide Tsujimoto Osaka University
Hideki Mochizuki
Hideki Mochizuki Osaka University

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