World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
17024
World Ranking
5700
National Ranking
367

Overview

Naoto Oku is affiliated with the University of Shizuoka in Japan and has made significant contributions to biochemistry, genetics, and molecular biology, with a primary focus on molecular biology, biomaterials, and pharmaceutical science.

Oku's research covers multiple subfields, including immunology and neurology, with notable specialization in nanoparticle-based drug delivery and RNA interference and gene delivery. Their work also addresses lipid membrane structure and behavior, advancements in transdermal drug delivery, bioanalysis techniques, and drug delivery systems. Additionally, Oku has contributed to studies on sepsis diagnosis and treatment.

Their recent publications demonstrate a diverse set of research topics and venues:

  • Synthetic hydrogel nanoparticles for sepsis therapy (2021, Nature Communications)
  • Charge-reversible lipid derivative: A novel type of pH-responsive lipid for nanoparticle-mediated siRNA delivery (2020, International Journal of Pharmaceutics)
  • Application and Utility of Liposomal Neuroprotective Agents and Biomimetic Nanoparticles for the Treatment of Ischemic Stroke (2022, Pharmaceutics)
  • Metastasis of Breast Cancer Promoted by Circadian Rhythm Disruption due to Light/Dark Shift and its Prevention by Dietary Quercetin in Mice (2021, Journal of Circadian Rhythms)
  • New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect (2021, Journal of Controlled Release)

Oku frequently publishes in several journals, reflecting the range and focus of their research:

  • Journal of Controlled Release (4 publications)
  • Biochemical and Biophysical Research Communications (4 publications)
  • Pharmaceutical Research (2 publications)
  • Nature Communications (1 publication)
  • International Journal of Pharmaceutics (1 publication)

Collaboration appears to be an important aspect of Oku's work. Frequent coauthors include:

  • Tomohiro Asai (18 joint works)
  • Hiroyuki Koide (13 joint works)
  • Yu Hoshino (5 joint works)
  • Sei Yonezawa (5 joint works)
  • Go Yasuno (5 joint works)

The breadth of Oku's expertise encompasses complex biochemical and pharmaceutical engineering topics, particularly involving nanoparticle technologies and gene delivery mechanisms. Their research reflects an interdisciplinary approach that integrates molecular biology with applied medicine and pharmaceutical sciences.

Best Publications

  • Tyrosine Phosphorylation of β-Catenin and Plakoglobin Enhanced by Hepatocyte Growth Factor and Epidermal Growth Factor in Human Carcinoma Cells

    S Shibamoto;M Hayakawa;K Takeuchi;T Hori

  • Recognition, Neutralization, and Clearance of Target Peptides in the Bloodstream of Living Mice by Molecularly Imprinted Polymer Nanoparticles: A Plastic Antibody

    Yu Hoshino;Hiroyuki Koide;Takeo Urakami;Hiroaki Kanazawa

  • The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo

    Yu Hoshino;Hiroyuki Koide;Keiichi Furuya;Walter W. Haberaecker

  • Oral delivery of insulin by using surface coating liposomes improvement of stability of insulin in GI tract

    Kazunori Iwanaga;Satoshi Ono;Kohji Narioka;Kazuhiro Morimoto

  • Application of surface‐coated liposomes for oral delivery of peptide: Effects of coating the liposome's surface on the GI transit of insulin

    Kazunori Iwanaga;Satoshi Ono;Kohji Narioka;Masawo Kakemi

  • Metabolic Fate of (−)-[4-3H]Epigallocatechin Gallate in Rats after Oral Administration

    Toshiyuki Kohri;Natsuki Matsumoto;Mana Yamakawa;Masayuki Suzuki

  • Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C.

    K Kaibuchi;Y Fukumoto;N Oku;Y Takai

  • Daily consumption of green tea catechin delays memory regression in aged mice.

    Keiko Unno;Fumiyo Takabayashi;Hirotoshi Yoshida;Daisuke Choba

  • Anti-neovascular therapy by use of tumor neovasculature-targeted long-circulating liposome.

    Noriyuki Maeda;Yoshito Takeuchi;Miki Takada;Yasuyuki Sadzuka

  • Long-circulating liposomes.

    N Oku;Y Namba

  • T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.

    Hiroyuki Koide;Tomohiro Asai;Kentaro Hatanaka;Shuji Akai

  • Anti-neovascular therapy using novel peptides homing to angiogenic vessels.

    Naoto Oku;Tomohiro Asai;Koh Watanabe;Koichi Kuromi

  • Particle size-dependent triggering of accelerated blood clearance phenomenon

    Hiroyuki Koide;Tomohiro Asai;Kentaro Hatanaka;Takeo Urakami

  • Susceptibility to kainate-induced seizures under dietary zinc deficiency.

    Atsushi Takeda;Maki Hirate;Haruna Tamano;Daisuke Nisibaba

  • Liposomes and nanotechnology in drug development: focus on ocular targets.

    Miki Honda;Tomohiro Asai;Naoto Oku;Yoshihiko Araki

  • Polycation liposomes, a novel nonviral gene transfer system, constructed from cetylated polyethylenimine

    Y Yamazaki;M Nango;M Matsuura;Y Hasegawa

  • Cadmium toxicity in synaptic neurotransmission in the brain.

    Akira Minami;Atsushi Takeda;Daisuke Nishibaba;Sachiyo Takefuta

  • Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10).

    Keiko Unno;Fumiyo Takabayashi;Takahiro Kishido;Naoto Oku

  • Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus.

    Atsushi Takeda;Akira Minami;Yumiko Seki;Naoto Oku

  • Prolonged Targeting of Ischemic/Reperfused Myocardium by Liposomal Adenosine Augments Cardioprotection in Rats

    Hiroyuki Takahama;Tetsuo Minamino;Hiroshi Asanuma;Masashi Fujita

Frequent Co-Authors

Hideo Tsukada
Hideo Tsukada Hamamatsu Photonics (Japan)
Kenneth J. Shea
Kenneth J. Shea University of California, Irvine
Somsak Ruchirawat
Somsak Ruchirawat Chulabhorn Research Institute
Shuji Akai
Shuji Akai Osaka University
Yoshitaka Hamashima
Yoshitaka Hamashima University of Shizuoka
Masafumi Kitakaze
Masafumi Kitakaze Southern Medical University
Takashi Suzuki
Takashi Suzuki University of Shizuoka
Shizuo Yamada
Shizuo Yamada University of Shizuoka
Takeharu Kakiuchi
Takeharu Kakiuchi Hamamatsu Photonics (Japan)
Ikuo Saiki
Ikuo Saiki University of Toyama

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