Takeharu Kakiuchi

Overview

Best Publications

• Ketamine decreased striatal [11C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: Multiparametric PET studies combined with microdialysis analysis

  Hideo Tsukada;Norihiro Harada;Shingo Nishiyama;Hiroyuki Ohba

  185
  Citations

• Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain

  Hideo Tsukada;Shingo Nishiyama;Takeharu Kakiuchi;Hiroyuki Ohba

  181
  Citations

• Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.

  Kenji Hashimoto;Takeharu Kakiuchi;Hiroyuki Ohba;Shingo Nishiyama

  155
  Citations

• Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [11C]raclopride?: PET studies combined with microdialysis in conscious monkeys

  Hideo Tsukada;Shingo Nishiyama;Takeharu Kakiuchi;Hiroyuki Ohba

  144
  Citations

• Comparative effects of methamphetamine and nicotine on the striatal [11C]raclopride binding in unanesthetized monkeys

  Hideo Tsukada;Katsumasa Miyasato;Takeharu Kakiuchi;Shingo Nishiyama

  136
  Citations

• Evaluation of 3'-deoxy-3'-18F-fluorothymidine for monitoring tumor response to radiotherapy and photodynamic therapy in mice.

  Masahiro Sugiyama;Harumi Sakahara;Kengo Sato;Norihiro Harada

  136
  Citations

• Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys.

  Hideo Tsukada;Takeharu Kakiuchi;Dai Fukumoto;Shingo Nishiyama

  135
  Citations

• Effects of binge pattern cocaine administration on dopamine D1 and D2 receptors in the rat brain: an in vivo study using positron emission tomography.

  Hideo Tsukada;Jason Kreuter;Christopher E. Maggos;Ellen M. Unterwald;Ellen M. Unterwald

  132
  Citations

• Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys.

  Hideo Tsukada;Shingo Nishiyama;Dai Fukumoto;Kengo Sato

  127
  Citations

• Cholinergic Neuronal Modulation Alters Dopamine D2Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain

  Hideo Tsukada;Norihiro Harada;Shingo Nishiyama;Hiroyuki Ohba

  127
  Citations

• Age-related changes in cerebral blood flow and glucose metabolism in conscious rhesus monkeys.

  Akihiro Noda;Hiroyuki Ohba;Takeharu Kakiuchi;Masami Futatsubashi

  122
  Citations

• Decline of striatal dopamine release in parkin‐deficient mice shown by ex vivo autoradiography

  Shigeto Sato;Shigeto Sato;Tomoki Chiba;Shingo Nishiyama;Takeharu Kakiuchi

  95
  Citations

• Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain.

  Hideo Tsukada;Shingo Nishiyama;Takeharu Kakiuchi;Hiroyuki Ohba

  95
  Citations

• Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

  Shigeyuki Yamamoto;Hiroyuki Ohba;Shingo Nishiyama;Norihiro Harada

  94
  Citations

• Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis.

  Hideo Tsukada;Shingo Nishiyama;Dai Fukumoto;Hiroyuki Ohba

  85
  Citations

• Evaluation of d-Isomers of O-11C-Methyl Tyrosine and O-18F-Fluoromethyl Tyrosine as Tumor-Imaging Agents in Tumor-Bearing Mice: Comparison with l- and d-11C-Methionine

  Hideo Tsukada;Kengo Sato;Dai Fukumoto;Shingo Nishiyama

  81
  Citations

• Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.

  Hideo Tsukada;Kengo Sato;Takeharu Kakiuchi;Shingo Nishiyama

  79
  Citations

• An increase of sigma1 receptors in the aged monkey brain

  Kazunori Kawamura;Yuichi Kimura;Hideo Tsukada;Tadayuki Kobayashi

  78
  Citations

• Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine.

  Kenji Hashimoto;Hideo Tsukada;Shingo Nishiyama;Dai Fukumoto

  78
  Citations

• Sustained Withdrawal Allows Normalization of In Vivo [11C]N-Methylspiperone Dopamine D2 Receptor Binding after Chronic Binge Cocaine: A Positron Emission Tomography Study in Rats

  Christopher E Maggos;Hideo Tsukada;Takeharu Kakiuchi;Shingo Nishiyama

  71
  Citations