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Overview

Shingo Nishiyama is affiliated with Hamamatsu Photonics in Japan and has contributed to research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work extends into various subfields including Molecular Biology, Physiology, Psychiatry and Mental Health, Oncology, and Pediatrics, Perinatology and Child Health.

Their research topics cover a range of areas with notable focus on Mitochondrial Function and Pathology, Drug Transport and Resistance Mechanisms, Pharmacological Effects and Toxicity Studies, Alzheimer's Disease Research and Treatments, Epilepsy Research and Treatment, Neuroinflammation and Neurodegeneration Mechanisms, and Neuroscience and Neuropharmacology Research.

Recent papers authored or co-authored by Nishiyama include:

  • 18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain, 2020, Organic & Biomolecular Chemistry
  • Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function, 2021, European Journal of Nuclear Medicine and Molecular Imaging
  • Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity, 2021, EJNMMI Research
  • Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates, 2020, Molecular Pharmaceutics
  • Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide, 2023, EMBO Molecular Medicine

Frequent co-authors collaborating with Nishiyama include:

  • Hideo Tsukada
  • Hiroyuki Ohba
  • Masakatsu Kanazawa
  • Takeharu Kakiuchi
  • Yasushi Arano

Their work has been published across several venues with multiple contributions, notable publication outlets include:

  • Research Square
  • Organic & Biomolecular Chemistry
  • European Journal of Nuclear Medicine and Molecular Imaging
  • EJNMMI Research
  • Molecular Pharmaceutics

Best Publications

  • Ketamine decreased striatal [11C]raclopride binding with no alterations in static dopamine concentrations in the striatal extracellular fluid in the monkey brain: Multiparametric PET studies combined with microdialysis analysis

    Hideo Tsukada;Norihiro Harada;Shingo Nishiyama;Hiroyuki Ohba

  • Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain

    Hideo Tsukada;Shingo Nishiyama;Takeharu Kakiuchi;Hiroyuki Ohba

  • Real Time Visualization of 13N-Translocation in Rice under Different Environmental Conditions Using Positron Emitting Tracer Imaging System

    Shoichiro Kiyomiya;Hiromi Nakanishi;Hiroshi Uchida;Atsunori Tsuji

  • Reduction of dopamine D2/3 receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.

    Kenji Hashimoto;Takeharu Kakiuchi;Hiroyuki Ohba;Shingo Nishiyama

  • Is synaptic dopamine concentration the exclusive factor which alters the in vivo binding of [11C]raclopride?: PET studies combined with microdialysis in conscious monkeys

    Hideo Tsukada;Shingo Nishiyama;Takeharu Kakiuchi;Hiroyuki Ohba

  • Comparative effects of methamphetamine and nicotine on the striatal [11C]raclopride binding in unanesthetized monkeys

    Hideo Tsukada;Katsumasa Miyasato;Takeharu Kakiuchi;Shingo Nishiyama

  • Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys.

    Hideo Tsukada;Takeharu Kakiuchi;Dai Fukumoto;Shingo Nishiyama

  • Effects of binge pattern cocaine administration on dopamine D1 and D2 receptors in the rat brain: an in vivo study using positron emission tomography.

    Hideo Tsukada;Jason Kreuter;Christopher E. Maggos;Ellen M. Unterwald;Ellen M. Unterwald

  • Chronic NMDA antagonism impairs working memory, decreases extracellular dopamine, and increases D1 receptor binding in prefrontal cortex of conscious monkeys.

    Hideo Tsukada;Shingo Nishiyama;Dai Fukumoto;Kengo Sato

  • Cholinergic Neuronal Modulation Alters Dopamine D2Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain

    Hideo Tsukada;Norihiro Harada;Shingo Nishiyama;Hiroyuki Ohba

  • Decline of striatal dopamine release in parkin‐deficient mice shown by ex vivo autoradiography

    Shigeto Sato;Shigeto Sato;Tomoki Chiba;Shingo Nishiyama;Takeharu Kakiuchi

  • Ketamine alters the availability of striatal dopamine transporter as measured by [(11)C]beta-CFT and [(11)C]beta-CIT-FE in the monkey brain.

    Hideo Tsukada;Shingo Nishiyama;Takeharu Kakiuchi;Hiroyuki Ohba

  • Subanesthetic Doses of Ketamine Transiently Decrease Serotonin Transporter Activity: A PET Study in Conscious Monkeys

    Shigeyuki Yamamoto;Hiroyuki Ohba;Shingo Nishiyama;Norihiro Harada

  • Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis.

    Hideo Tsukada;Shingo Nishiyama;Dai Fukumoto;Hiroyuki Ohba

  • Development of novel PET probes, [18F]BCPP-EF, [18F]BCPP-BF, and [11C]BCPP-EM for mitochondrial complex 1 imaging in the living brain.

    Norihiro Harada;Shingo Nishiyama;Masakatsu Kanazawa;Hideo Tsukada

  • Evaluation of d-Isomers of O-11C-Methyl Tyrosine and O-18F-Fluoromethyl Tyrosine as Tumor-Imaging Agents in Tumor-Bearing Mice: Comparison with l- and d-11C-Methionine

    Hideo Tsukada;Kengo Sato;Dai Fukumoto;Shingo Nishiyama

  • [11C]CHIBA-1001 as a Novel PET Ligand for α7 Nicotinic Receptors in the Brain: A PET Study in Conscious Monkeys

    Kenji Hashimoto;Shingo Nishiyama;Hiroyuki Ohba;Masaaki Matsuo

  • Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.

    Hideo Tsukada;Kengo Sato;Takeharu Kakiuchi;Shingo Nishiyama

  • An increase of sigma1 receptors in the aged monkey brain

    Kazunori Kawamura;Yuichi Kimura;Hideo Tsukada;Tadayuki Kobayashi

  • Protective effects of N-acetyl-L-cysteine on the reduction of dopamine transporters in the striatum of monkeys treated with methamphetamine.

    Kenji Hashimoto;Hideo Tsukada;Shingo Nishiyama;Dai Fukumoto

Frequent Co-Authors

Hideo Tsukada
Hideo Tsukada Hamamatsu Photonics (Japan)
Takeharu Kakiuchi
Takeharu Kakiuchi Hamamatsu Photonics (Japan)
Yasuomi Ouchi
Yasuomi Ouchi Hamamatsu University
Edward F. Domino
Edward F. Domino University of Michigan–Ann Arbor
Hiromi Nakanishi
Hiromi Nakanishi University of Tokyo
Kohji Sato
Kohji Sato Hamamatsu University
Hirotaka Onoe
Hirotaka Onoe Kyoto University
Kengo Ito
Kengo Ito Nagoya University
Yasuyoshi Watanabe
Yasuyoshi Watanabe Osaka Metropolitan University
Naoko K. Nishizawa
Naoko K. Nishizawa Ishikawa Prefectural University

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