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Medicine

D-Index
77
Citations
22279
World Ranking
18411
National Ranking
9184

Overview

Yiyun Huang is affiliated with Yale University in the United States. Their research focuses on areas spanning medicine, neuroscience, and biochemistry, genetics, and molecular biology. Within these fields, their work is particularly concentrated in cellular and molecular neuroscience, molecular biology, physiology, radiology, nuclear medicine and imaging, and cognitive neuroscience.

The main topics of Yiyun Huang's research include neuroscience and neuropharmacology research, Alzheimer's disease research and treatments, functional brain connectivity studies, receptor mechanisms and signaling, neuropeptides and animal physiology, pharmacological receptor mechanisms and effects, and neuroinflammation and neurodegeneration mechanisms.

Yiyun Huang's recent publications illustrate a consistent engagement with neurodegenerative disease imaging and measurement, especially related to synaptic density and cognitive performance. Some notable recent papers are:

  • In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET, 2020, Alzheimer's & Dementia
  • Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging, 2020, Annals of Neurology
  • Synaptic density and cognitive performance in Alzheimer's disease: A PET imaging study with [11C]UCB-J, 2022, Alzheimer's & Dementia
  • First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A, 2020, Journal of Nuclear Medicine
  • Association of Aβ deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J, 2021, Alzheimer's Research & Therapy

Their frequent co-authors reflect collaboration mainly with researchers experienced in neurology and nuclear medicine, including:

  • Richard E. Carson
  • Nabeel Nabulsi
  • Jim Ropchan
  • Mika Naganawa
  • Takuya Toyonaga

Yiyun Huang has contributed extensively to several key publication venues, reflecting the interdisciplinary nature of their work at the intersection of neurology, imaging, and psychiatry. These venues include:

  • Alzheimer's & Dementia
  • European Journal of Nuclear Medicine and Molecular Imaging
  • Journal of Nuclear Medicine
  • Biological Psychiatry
  • American Journal of Geriatric Psychiatry

Their research involves advanced imaging techniques applied to neurodegenerative diseases, with a focus on PET imaging to quantify synaptic loss and alterations. This work contributes to understanding disease progression and cognitive decline in disorders such as Alzheimer's and Parkinson's disease.

Best Publications

  • Prefrontal dopamine D1 receptors and working memory in schizophrenia.

    Anissa Abi-Dargham;Osama Mawlawi;Ilise Lombardo;Roberto Gil

  • PET imaging of serotonin 1A receptor binding in depression

    Wayne C Drevets;Ellen Frank;Julie C Price;David J Kupfer

  • Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography: I. Accuracy and Precision of D2 Receptor Parameter Measurements in Ventral Striatum:

    Osama Mawlawi;Diana Martinez;Mark Slifstein;Allegra Broft

  • Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum.

    Diana Martinez;Mark Slifstein;Allegra Broft;Osama Mawlawi

  • Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.

    Lawrence S. Kegeles;Anissa Abi-Dargham;W. Gordon Frankle;Roberto Gil

  • Imaging synaptic density in the living human brain

    Sjoerd J. Finnema;Nabeel B. Nabulsi;Tore Eid;Kamil Detyniecki

  • Alcohol Dependence Is Associated with Blunted Dopamine Transmission in the Ventral Striatum

    Diana Martinez;Roberto Gil;Mark Slifstein;Dah Ren Hwang

  • Deficits in Prefrontal Cortical and Extrastriatal Dopamine Release in Schizophrenia: A Positron Emission Tomographic Functional Magnetic Resonance Imaging Study

    Mark Slifstein;Mark Slifstein;Elsmarieke van de Giessen;Elsmarieke van de Giessen;Jared Van Snellenberg;Jared Van Snellenberg;Judy L. Thompson;Judy L. Thompson;Judy L. Thompson

  • Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.

    Ming-Kai Chen;Adam P. Mecca;Mika Naganawa;Sjoerd J. Finnema

  • Amphetamine-Induced Dopamine Release: Markedly Blunted in Cocaine Dependence and Predictive of the Choice to Self-Administer Cocaine

    Diana Martinez;Rajesh Narendran;Richard W. Foltin;Mark Slifstein

  • Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study.

    Alexander Neumeister;Marc D. Normandin;Marc D. Normandin;Robert H. Pietrzak;Robert H. Pietrzak;Daniele Piomelli

  • Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

    Christine M. Sandiego;Jean-Dominique Gallezot;Brian Pittman;Nabeel Nabulsi

  • Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior.

    Diana Martinez;Allegra Broft;Richard W Foltin;Mark Slifstein

  • Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652.

    W. Gordon Frankle;Ilise Lombardo;Antonia S. New;Marianne Goodman

  • Synthesis and Preclinical Evaluation of 11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain

    Nabeel B. Nabulsi;Joël Mercier;Daniel Holden;Stephane Carré

  • Lower Serotonin Transporter Binding Potential in the Human Brain During Major Depressive Episodes

    Ramin V. Parsey;Ramin S. Hastings;Maria A. Oquendo;Yung-yu Huang

  • Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain.

    Ramin V. Parsey;Ramin S. Hastings;Maria A. Oquendo;Xianzhang Hu

  • Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma

    Jiangbing Zhou;Toral R. Patel;Rachael W. Sirianni;Garth Strohbehn

  • Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography.

    Marc Laruelle;Mark Slifstein;Yiyun Huang

  • In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride.

    Rajesh Narendran;Dah Ren Hwang;Mark Slifstein;Peter S. Talbot

Frequent Co-Authors

Richard E. Carson
Richard E. Carson Yale University
Nabeel Nabulsi
Nabeel Nabulsi Yale University
Mika Naganawa
Mika Naganawa Yale University
Marc Laruelle
Marc Laruelle Columbia University
Kelly P. Cosgrove
Kelly P. Cosgrove Yale University
Alexander Neumeister
Alexander Neumeister Independent Scientist / Consultant, US
Yu-Shin Ding
Yu-Shin Ding New York University
Diana Martinez
Diana Martinez Columbia University

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