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Biology and Biochemistry

D-Index
46
Citations
10930
World Ranking
18850
National Ranking
7703

Overview

M. Jackson Stutts is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on the field of Medicine, with a significant emphasis on Pulmonary and Respiratory Medicine. They have also contributed to Molecular Biology, Cellular and Molecular Neuroscience, Physiology, and Immunology and Allergy.

The scientist's work covers several interconnected topics, including:

  • Cystic Fibrosis Research Advances
  • Neuroscience and Neural Engineering
  • Photoreceptor and Optogenetics Research
  • Cancer-related Gene Regulation
  • Respiratory Support and Mechanisms
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Obstructive Sleep Apnea Research

M. Jackson Stutts has published extensively, including papers in prominent venues such as UNC Libraries, Science Translational Medicine, and OPAL (Open@LaTrobe) at La Trobe University. The following are some of their recent publications:

  • "Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration," 2023, Science Translational Medicine
  • "Preferential Assembly of Epithelial Sodium Channel (ENaC) Subunits in Xenopus Oocytes: ROLE OF FURIN-MEDIATED ENDOGENOUS PROTEOLYSIS," 2020, UNC Libraries
  • "SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes," 2020, UNC Libraries
  • "Inhibition of Protease-Epithelial Sodium Channel Signaling Improves Mucociliary Function in Cystic Fibrosis Airways," 2024, UNC Libraries
  • "Energetic and Structural Basis for Activation of the Epithelial Sodium Channel by Matriptase," 2020, OPAL (Open@LaTrobe) (La Trobe University)

Their collaborations include frequent co-authorship with several researchers, notably:

  • Sharon L. Milgram
  • Martina Gentzsch
  • Pradeep Kota
  • Richard C. Boucher
  • Robert Tarran

Most of M. Jackson Stutts' publications have appeared in UNC Libraries, reflecting a consistent output in this venue. Their contributions also extend to a multidisciplinary approach bridging pulmonary medicine with molecular biology and neuroscience.

The research topics and publication record indicate a particular interest in the molecular mechanisms regulating epithelial sodium channels, airway pathology, and mucociliary function, especially within the context of cystic fibrosis and related pulmonary diseases.

Best Publications

  • CFTR as a cAMP-dependent regulator of sodium channels.

    MJ Stutts;CM Canessa;JC Olsen;M Hamrick

  • Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model

    SE Gabriel;KN Brigman;BH Koller;RC Boucher

  • Abnormal ion permeation through cystic fibrosis respiratory epithelium

    Michael R Knowles;Monroe Jack Stutts;A. Spock;N. Fischer

  • An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton

    Douglas B. Short;Kevin W. Trotter;David Reczek;Silvia M. Kreda

  • CFTR Is a Conductance Regulator as well as a Chloride Channel

    Erik M. Schwiebert;Dale J. Benos;Marie E. Egan;Monroe Jack Stutts

  • CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship

    Sherif E. Gabriel;Lane L. Clarke;Richard C. Boucher;M. Jackson Stutts

  • Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate.

    Eduardo R. Lazarowski;William C. Watt;M. Jackson Stutts;Richard C. Boucher

  • Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport

    Ray A. Caldwell;Richard C. Boucher;M. Jackson Stutts

  • Cystic Fibrosis Transmembrane Conductance Regulator Inverts Protein Kinase A-mediated Regulation of Epithelial Sodium Channel Single Channel Kinetics

    M. Jackson Stutts;Bernard C. Rossier;Richard C. Boucher

  • Activation of the epithelial sodium channel (ENaC) by serine proteases

    Bernard C. Rossier;M. Jackson Stutts

  • Serine protease activation of near-silent epithelial Na+ channels.

    Ray A. Caldwell;Richard C. Boucher;M. Jackson Stutts

  • Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells

    P Huang;E R Lazarowski;R Tarran;S L Milgram

  • Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50

    Peter J. Mohler;Silvia M. Kreda;Richard C. Boucher;Marius Sudol

  • Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

    Alaina L. Garland;William G. Walton;Raymond D. Coakley;Chong D. Tan

  • Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis.

    C. U. Cotton;Monroe Jack Stutts;Michael R Knowles;J. T. Gatzy

  • SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage

    Agustin Garcia-Caballero;Julia E. Rasmussen;Erol Gaillard;Michael J. Watson

  • Regional differences in airway surface liquid composition

    R. C. Boucher;M. J. Stutts;P. A. Bromberg;J. T. Gatzy

  • Regulation of Cl- channels in normal and cystic fibrosis airway epithelial cells by extracellular ATP.

    M J Stutts;T C Chinet;S J Mason;J M Fullton

  • Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP.

    M. J. Stutts;John G Fitz;A. M. Paradiso;R. C. Boucher

  • Phosphodiesterase 4D Forms a cAMP Diffusion Barrier at the Apical Membrane of the Airway Epithelium

    Anthony P. Barnes;Gabriel Livera;Pingbo Huang;Chuanwen Sun

Frequent Co-Authors

Richard C. Boucher
Richard C. Boucher University of North Carolina at Chapel Hill
Robert Tarran
Robert Tarran University of North Carolina at Chapel Hill
Nikolay V. Dokholyan
Nikolay V. Dokholyan Pennsylvania State University
Bernard C. Rossier
Bernard C. Rossier University of Lausanne
John C. Olsen
John C. Olsen University of North Carolina at Chapel Hill
Michael R. Knowles
Michael R. Knowles University of North Carolina at Chapel Hill
Matthew R. Redinbo
Matthew R. Redinbo University of North Carolina at Chapel Hill
Scott H. Randell
Scott H. Randell University of North Carolina at Chapel Hill
Eduardo R. Lazarowski
Eduardo R. Lazarowski University of North Carolina at Chapel Hill
Peter J. Mohler
Peter J. Mohler The Ohio State University

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