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Biology and Biochemistry

D-Index
73
Citations
19165
World Ranking
5933
National Ranking
2808

Overview

Eduardo R. Lazarowski is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Physiology, Molecular Biology, Pulmonary and Respiratory Medicine, Endocrine and Autonomic Systems, and Epidemiology.

Their work focuses extensively on topics related to adenosine and purinergic signaling, neonatal respiratory health research, neuroscience of respiration and sleep, cystic fibrosis research advances, pancreatic function and diabetes, genetic neurodegenerative diseases, and biochemical and molecular research.

Frequent publication venues for Lazarowski include UNC Libraries, which accounts for a majority of their publications. Other venues where they have published include npj Aging and Mechanisms of Disease, Journal of Clinical Investigation, American Journal of Physiology-Heart and Circulatory Physiology, and Biochemical Pharmacology.

Some of their recent papers are:

  • Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice, 2020, Journal of Clinical Investigation
  • Pannexin 1 channels control the hemodynamic response to hypoxia by regulating O2-sensitive extracellular ATP in blood, 2021, American Journal of Physiology-Heart and Circulatory Physiology
  • Purinergic receptors in airway hydration, 2021, Biochemical Pharmacology
  • Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease, 2021, npj Aging and Mechanisms of Disease
  • Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance, 2021, Life

Lazarowski has collaborated frequently with several co-authors including Richard C. Boucher, Seiko F. Okada, Silvia M. Kreda, Juliana I. Sesma, and T. Kendall Harden.

Best Publications

  • Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

    Michael R. Elliott;Faraaz B. Chekeni;Paul C. Trampont;Eduardo R. Lazarowski

  • Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

    Faraaz B. Chekeni;Michael R. Elliott;Michael R. Elliott;Joanna K. Sandilos;Scott F. Walk;Scott F. Walk

  • Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules.

    Eduardo R. Lazarowski;Richard C. Boucher;T. Kendall Harden

  • Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration

    Patrick Weydt;Victor V. Pineda;Anne E. Torrence;Randell T. Libby

  • Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy.

    C E Parr;D M Sullivan;A M Paradiso;E R Lazarowski

  • Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.

    Robert A. Nicholas;William C. Watt;Eduardo R. Lazarowski;Qing Li

  • Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase.

    Jaroslaw W. Zmijewski;Sami Banerjee;Hongbeom Bae;Arnaud Friggeri

  • PGC-1α Rescues Huntington’s Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

    Taiji Tsunemi;Travis D. Ashe;Bradley E. Morrison;Kathryn R. Soriano

  • Constitutive Release of ATP and Evidence for Major Contribution of Ecto-nucleotide Pyrophosphatase and Nucleoside Diphosphokinase to Extracellular Nucleotide Concentrations

    Eduardo R. Lazarowski;Richard C. Boucher;T. Kendall Harden

  • Normal and Cystic Fibrosis Airway Surface Liquid Homeostasis THE EFFECTS OF PHASIC SHEAR STRESS AND VIRAL INFECTIONS

    Robert Tarran;Brian Button;Maryse Picher;Anthony M. Paradiso

  • Direct Demonstration of Mechanically Induced Release of Cellular UTP and Its Implication for Uridine Nucleotide Receptor Activation

    Eduardo R. Lazarowski;László Homolya;Richard C. Boucher;T. Kendall Harden

  • Pharmacological selectivity of the cloned human P2U-purinoceptor: potent activation by diadenosine tetraphosphate.

    Eduardo R. Lazarowski;William C. Watt;M. Jackson Stutts;Richard C. Boucher

  • Vesicular and conductive mechanisms of nucleotide release.

    Eduardo R. Lazarowski

  • Regulation of carbamoyl phosphate synthetase by MAP kinase.

    Lee M. Graves;Hedeel I. Guy;Piotr Kozlowski;Min Huang

  • In vitro model of angiogenesis using a human endothelium-derived permanent cell line: contributions of induced gene expression, G-proteins, and integrins.

    Jeffrey Bauer;Michael Margolis;Clara Schreiner;Cora‐Jean ‐J Edgell

  • Nucleotide Release Provides a Mechanism for Airway Surface Liquid Homeostasis

    Eduardo R. Lazarowski;Robert Tarran;Barbara R. Grubb;Catharina A. van Heusden

  • Physiological regulation of ATP release at the apical surface of human airway epithelia.

    Seiko F. Okada;Robert A. Nicholas;Silvia M. Kreda;Eduardo R. Lazarowski

  • Effect of Loss of P2Y2 Receptor Gene Expression on Nucleotide Regulation of Murine Epithelial Cl−Transport

    Victoria L. Cressman;Eduardo R Lazarowski;László Homolya;Richard C Boucher

  • Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.

    H A Brown;E R Lazarowski;R C Boucher;T K Harden

  • Compartmentalized autocrine signaling to cystic fibrosis transmembrane conductance regulator at the apical membrane of airway epithelial cells

    P Huang;E R Lazarowski;R Tarran;S L Milgram

Frequent Co-Authors

Richard C. Boucher
Richard C. Boucher University of North Carolina at Chapel Hill
T. Kendall Harden
T. Kendall Harden University of North Carolina at Chapel Hill
Wanda K. O'Neal
Wanda K. O'Neal University of North Carolina at Chapel Hill
Robert A. Nicholas
Robert A. Nicholas University of North Carolina at Chapel Hill
Neil E. Alexis
Neil E. Alexis University of North Carolina at Chapel Hill
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health
Kodi S. Ravichandran
Kodi S. Ravichandran University of Virginia
Albert R. La Spada
Albert R. La Spada University of California, Irvine
David Erlinge
David Erlinge Lund University
Raymond J. Pickles
Raymond J. Pickles University of North Carolina at Chapel Hill

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