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Biology and Biochemistry

D-Index
72
Citations
18730
World Ranking
6295
National Ranking
2951

Overview

Wanda K. O'Neal is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on medicine, with a significant emphasis on pulmonary and respiratory medicine. Additional subfields of their work include molecular biology, physiology, genetics, and epidemiology.

The scientist's main research topics encompass a range of respiratory and pulmonary health issues. These include:

  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Asthma and respiratory diseases
  • Respiratory Support and Mechanisms
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Tracheal and airway disorders

O'Neal's recent publications demonstrate involvement in studies related to respiratory diseases and molecular mechanisms. Notable papers include:

  • "SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract," 2020, published in Cell
  • "Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort," 2021, published in The Lancet Respiratory Medicine
  • "Comparison of Proteomic Assessment Methods in Multiple Cohort Studies," 2020, published in PROTEOMICS
  • "Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis," 2020, published in Cell
  • "Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers," 2020, published in American Journal of Respiratory and Critical Care Medicine

The scientist frequently collaborates with other researchers, including:

  • Richard C. Boucher
  • Hong Dang
  • Prescott G. Woodruff
  • Jeffrey L. Curtis
  • Fernando J. Martínez

O'Neal's publication venues indicate a consistent focus on respiratory health and related medical research, with frequent articles appearing in:

  • UNC Libraries
  • American Journal of Respiratory and Critical Care Medicine
  • Journal of Cystic Fibrosis
  • bioRxiv (Cold Spring Harbor Laboratory)
  • CHEST Journal

Best Publications

  • SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.

    Yixuan J. Hou;Kenichi Okuda;Caitlin E. Edwards;David R. Martinez

  • Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.

    Marcus Mall;Barbara R Grubb;Jack R Harkema;Wanda K O'Neal

  • Muc5b is required for airway defence

    Michelle G. Roy;Alessandra Livraghi-Butrico;Ashley A. Fletcher;Melissa M. McElwee

  • Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons

    Núria Morral;Wanda O’Neal;Karen Rice;Michele Leland

  • Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65.

    Elizabeth M. Morin-Kensicki;Brian N. Boone;Michael Howell;Jaclyn R. Stonebraker

  • Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

    Mehmet Kesimer;Margaret Scull;Brian Brighton;Genevieve DeMaria

  • Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium

    Raymond D. Coakley;Barbara R. Grubb;Anthony M. Paradiso;John T. Gatzy

  • Airway Mucin Concentration as a Marker of Chronic Bronchitis.

    Mehmet Kesimer;Amina A. Ford;Agathe Ceppe;Giorgia Radicioni

  • Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

    MeiLan K Han;Pedro M Quibrera;Elizabeth E Carretta;R Graham Barr

  • Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort.

    Annette T Hastie;Fernando J Martinez;Jeffrey L Curtis;Claire M Doerschuk

  • Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways.

    Jason R. Rock;Wanda K. O'Neal;Sherif E. Gabriel;Scott H. Randell

  • Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

    Harriet Corvol;Harriet Corvol;Scott M Blackman;Pierre-Yves Boëlle;Paul J Gallins

  • Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.

    Fred A. Wright;Lisa J. Strug;Vishal K. Doshi;Clayton W. Commander

  • Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

    Kenichi Okuda;Gang Chen;Durai B. Subramani;Monroe Wolf

  • Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia

    Lucia Seminario-Vidal;Seiko F. Okada;Juliana I. Sesma;Silvia M. Kreda

  • Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice

    Marcus A. Mall;Jack R. Harkema;Joanna B. Trojanek;Diana Treis

  • Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

    Lei Sun;Johanna M. Rommens;Harriet Corvol;Harriet Corvol;Weili Li

  • NSP4 elicits age-dependent diarrhea and Ca2+mediated I− influx into intestinal crypts of CF mice

    Andrew P. Morris;Jason K. Scott;Judith M. Ball;Carl Q.-Y. Zeng

  • Chronic Airway Infection/Inflammation Induces a Ca2+i-dependent Hyperinflammatory Response in Human Cystic Fibrosis Airway Epithelia

    Carla Maria Pedrosa Ribeiro;Anthony M. Paradiso;Ute Schwab;Juan Perez-Vilar

  • Coordinated release of nucleotides and mucin from human airway epithelial Calu‐3 cells

    Silvia M. Kreda;Seiko F. Okada;Catharina A. Van Heusden;Wanda O'Neal

Frequent Co-Authors

Richard C. Boucher
Richard C. Boucher University of North Carolina at Chapel Hill
Fernando J. Martinez
Fernando J. Martinez University of Massachusetts Chan Medical School
MeiLan K. Han
MeiLan K. Han University of Michigan–Ann Arbor
Jeffrey L. Curtis
Jeffrey L. Curtis University of Michigan–Ann Arbor
Prescott G. Woodruff
Prescott G. Woodruff University of California, San Francisco
Eric A. Hoffman
Eric A. Hoffman University of Iowa
Nadia N. Hansel
Nadia N. Hansel Johns Hopkins University
Eugene R. Bleecker
Eugene R. Bleecker University of Arizona
R. Graham Barr
R. Graham Barr Columbia University
David Couper
David Couper University of North Carolina at Chapel Hill

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