D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 96 Citations 34,201 375 World Ranking 5856 National Ranking 3234
Genetics D-index 91 Citations 32,033 337 World Ranking 656 National Ranking 329

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Mutation

Michael R. Knowles focuses on Cystic fibrosis, Pathology, Internal medicine, Primary ciliary dyskinesia and Cystic fibrosis transmembrane conductance regulator. His research integrates issues of Sputum, Lung, Immunology and Amiloride in his study of Cystic fibrosis. In general Pathology study, his work on Respiratory epithelium often relates to the realm of Potential difference, thereby connecting several areas of interest.

His work deals with themes such as Gastroenterology, Endocrinology, Mucous membrane of nose and Transepithelial potential difference, which intersect with Internal medicine. His studies deal with areas such as Dynein, Cilium and Situs inversus as well as Primary ciliary dyskinesia. His studies in Cystic fibrosis transmembrane conductance regulator integrate themes in fields like Mutation, Genetic enhancement, Pancreatitis and Genotype.

His most cited work include:

  • Mucus clearance as a primary innate defense mechanism for mammalian airways (930 citations)
  • Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. (751 citations)
  • Primary ciliary dyskinesia: diagnostic and phenotypic features. (635 citations)

What are the main themes of his work throughout his whole career to date?

Michael R. Knowles mainly investigates Cystic fibrosis, Primary ciliary dyskinesia, Internal medicine, Pathology and Genetics. His work on Cystic fibrosis transmembrane conductance regulator as part of general Cystic fibrosis research is frequently linked to Pancreatic disease, bridging the gap between disciplines. His Cystic fibrosis transmembrane conductance regulator study combines topics from a wide range of disciplines, such as Molecular biology and Genotype.

His Primary ciliary dyskinesia research is multidisciplinary, incorporating elements of Dynein, Cilium, Motile cilium and Situs inversus. His work in Internal medicine addresses issues such as Endocrinology, which are connected to fields such as Epithelium. His biological study spans a wide range of topics, including Airway, Respiratory system and Mucociliary clearance.

He most often published in these fields:

  • Cystic fibrosis (42.36%)
  • Primary ciliary dyskinesia (31.12%)
  • Internal medicine (29.39%)

What were the highlights of his more recent work (between 2016-2021)?

  • Primary ciliary dyskinesia (31.12%)
  • Internal medicine (29.39%)
  • Bronchiectasis (10.37%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Primary ciliary dyskinesia, Internal medicine, Bronchiectasis, Cystic fibrosis and Cilium. The various areas that Michael R. Knowles examines in his Primary ciliary dyskinesia study include Cell biology, Mucociliary clearance, Motile cilium and Pathology. His Pathology research is multidisciplinary, relying on both Proteome, Low nasal nitric oxide, Situs inversus and Respiratory system.

His Internal medicine research focuses on Gastroenterology and how it connects with Airway, Liver transplantation and Case-control study. His Cystic fibrosis research incorporates elements of Genome-wide association study, Bioinformatics, Phenotype, Immunology and Lung disease. His work on Ciliogenesis is typically connected to Body movement as part of general Cilium study, connecting several disciplines of science.

Between 2016 and 2021, his most popular works were:

  • Adult Patients With Bronchiectasis: A First Look at the US Bronchiectasis Research Registry. (132 citations)
  • Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline. (104 citations)
  • De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry. (35 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Mutation

Michael R. Knowles mainly investigates Primary ciliary dyskinesia, Internal medicine, Cystic fibrosis, Bronchiectasis and Cilium. The Primary ciliary dyskinesia study combines topics in areas such as Mucociliary clearance, Cohort study, Pathology and MEDLINE. His study in Pathology is interdisciplinary in nature, drawing from both Hypertonic saline, Inhalation and Respiratory system.

He has researched Internal medicine in several fields, including Type 1 diabetes and Type 2 diabetes. His Cystic fibrosis research is included under the broader classification of Genetics. His Cilium study combines topics in areas such as Obstructive lung disease, Gene, Compound heterozygosity and Ciliary Motility Disorders.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Mucus clearance as a primary innate defense mechanism for mammalian airways

Michael R. Knowles;Richard C. Boucher.
Journal of Clinical Investigation (2002)

1430 Citations

Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.

Jonathan A. Cohn;Kenneth J. Friedman;Peadar G. Noone;Michael R. Knowles.
The New England Journal of Medicine (1998)

1086 Citations

Primary ciliary dyskinesia: diagnostic and phenotypic features.

Peadar G Noone;Margaret W Leigh;Aruna Sannuti;Susan L. Minnix.
American Journal of Respiratory and Critical Care Medicine (2004)

817 Citations

Mucus clearance and lung function in cystic fibrosis with hypertonic saline.

Scott H. Donaldson;William D. Bennett;Kirby L. Zeman;Michael R. Knowles.
The New England Journal of Medicine (2006)

790 Citations

Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice

C. Castellani;H. Cuppens;M. Macek;J. J. Cassiman.
Journal of Cystic Fibrosis (2008)

765 Citations

Increased Bioelectric Potential Difference across Respiratory Epithelia in Cystic Fibrosis

Michael R Knowles;John Gatzy;Richard C Boucher.
The New England Journal of Medicine (1981)

750 Citations

A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

Michael R Knowles;Kathy W. Hohneker;Zhaoqing Zhou;John C. Olsen.
The New England Journal of Medicine (1995)

692 Citations

Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

R C Boucher;M J Stutts;M R Knowles;L Cantley.
Journal of Clinical Investigation (1986)

685 Citations

Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis.

Kenneth N. Olivier;David Jay Weber;Richard J. Wallace;Ali R. Faiz.
American Journal of Respiratory and Critical Care Medicine (2003)

663 Citations

Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis.

Michael R. Knowles;Lane L. Clarke;Richard C. Boucher.
The New England Journal of Medicine (1991)

594 Citations

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