World's Best Scientists 2026 revealed!

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Genetics

D-Index
97
Citations
36879
World Ranking
837
National Ranking
422

Medicine

D-Index
104
Citations
40604
World Ranking
7039
National Ranking
3700

Overview

Michael R. Knowles is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on medicine, with a significant volume of work within biochemistry, genetics, and molecular biology.

The scientist's work is concentrated in several subfields including pulmonary and respiratory medicine, genetics, molecular biology, surgery, and epidemiology. Their main topics of research encompass cystic fibrosis research advances, neonatal respiratory health, tracheal and airway disorders, genetic and kidney cyst diseases, pediatric health and respiratory diseases, genomics and rare diseases, as well as microtubule and mitosis dynamics.

Frequent publication venues for Michael R. Knowles include:

  • UNC Libraries
  • Pediatric Pulmonology
  • Annals of the American Thoracic Society
  • Journal of Cystic Fibrosis
  • American Journal of Respiratory and Critical Care Medicine

Frequent co-authors in Knowles's research collaborations are:

  • Margaret W. Leigh
  • Maimoona A. Zariwala
  • Rhonda G. Pace
  • Stephanie D. Davis
  • Garry R. Cutting

Recent publications representative of their research include:

  • "A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance," 2020, Nature Medicine
  • "Benign missense variations in the cystic fibrosis gene," 2020, PubMed
  • "Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia," 2020, PLoS Genetics
  • "Airway Clearance Techniques in Bronchiectasis," 2020, CHEST Journal
  • "Limitations of Nasal Nitric Oxide Testing in Primary Ciliary Dyskinesia," 2020, American Journal of Respiratory and Critical Care Medicine

The research spans various aspects of respiratory and genetic disorders, notably focusing on ciliary function and cystic fibrosis. Their publications address both clinical and molecular biology aspects of pulmonary health and disease, contributing to understanding airway clearance, genetic mutations affecting ciliary function, and diagnostic limitations related to respiratory conditions.

Best Publications

  • Mucus clearance as a primary innate defense mechanism for mammalian airways

    Michael R. Knowles;Richard C. Boucher

  • Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.

    Jonathan A. Cohn;Kenneth J. Friedman;Peadar G. Noone;Michael R. Knowles

  • Primary ciliary dyskinesia: diagnostic and phenotypic features.

    Peadar G Noone;Margaret W Leigh;Aruna Sannuti;Susan L. Minnix

  • Mucus clearance and lung function in cystic fibrosis with hypertonic saline.

    Scott H. Donaldson;William D. Bennett;Kirby L. Zeman;Michael R. Knowles

  • Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice

    C. Castellani;H. Cuppens;M. Macek;J. J. Cassiman

  • Increased Bioelectric Potential Difference across Respiratory Epithelia in Cystic Fibrosis

    Michael R Knowles;John Gatzy;Richard C Boucher

  • Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis.

    Kenneth N. Olivier;David Jay Weber;Richard J. Wallace;Ali R. Faiz

  • A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis

    Michael R Knowles;Kathy W. Hohneker;Zhaoqing Zhou;John C. Olsen

  • Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.

    R C Boucher;M J Stutts;M R Knowles;L Cantley

  • Mutations in DNAH5 cause primary ciliary dyskinesia and randomization of left–right asymmetry

    Heike Olbrich;Karsten Häffner;Andreas Kispert;Alexander Völkel

  • Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis.

    Michael R. Knowles;Lane L. Clarke;Richard C. Boucher

  • Genetic Modifiers of Lung Disease in Cystic Fibrosis

    Mitchell L. Drumm;Michael W. Konstan;Mark D. Schluchter;Allison Handler

  • Abnormal ion permeation through cystic fibrosis respiratory epithelium

    Michael R Knowles;Monroe Jack Stutts;A. Spock;N. Fischer

  • Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome.

    Margaret W Leigh;Jessica E. Pittman;Johnny Lee Carson;Thomas W. Ferkol

  • Primary Ciliary Dyskinesia. Recent Advances in Diagnostics, Genetics, and Characterization of Clinical Disease

    Michael R. Knowles;Leigh Anne Daniels;Stephanie D. Davis;Maimoona A. Zariwala

  • A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations

    W. Edward Highsmith;Lauranell H. Burch;Zhaoqing Zhou;John C. Olsen

  • Congenital Heart Disease and Other Heterotaxic Defects in a Large Cohort of Patients With Primary Ciliary Dyskinesia

    Marcus P. Kennedy;Heymut Omran;Margaret W. Leigh;Sharon Dell

  • Recommendations for the classification of diseases as CFTR-related disorders

    Cristina Bombieri;M Claustres;K De Boeck;N Derichs

  • In Vivo Nasal Potential Difference: Techniques and Protocols for Assessing Efficacy of Gene Transfer in Cystic Fibrosis

    M. R. Knowles;A. M. Paradiso;R. C. Boucher

  • Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease.

    Kenneth N. Olivier;David J. Weber;Ji Hyun Lee;Allison Handler

Frequent Co-Authors

Richard C. Boucher
Richard C. Boucher University of North Carolina at Chapel Hill
Kenneth N. Olivier
Kenneth N. Olivier National Institutes of Health
Garry R. Cutting
Garry R. Cutting Johns Hopkins University School of Medicine
Heymut Omran
Heymut Omran University of Münster
Margaret Rosenfeld
Margaret Rosenfeld University of Washington
Wanda K. O'Neal
Wanda K. O'Neal University of North Carolina at Chapel Hill
Peter R. Durie
Peter R. Durie University of Toronto
Fred A. Wright
Fred A. Wright North Carolina State University
Charles L. Daley
Charles L. Daley National Jewish Health
Kevin L. Winthrop
Kevin L. Winthrop Oregon Health & Science University

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